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New effects of an antihistaminic against cerebral injury

t for cerebral ischemia in humans, in that, obviously, therapeutic treatments always take place after the time of the infarct or traumatism.

The authors of the research, recently published in Stroke magazine, affirm that the most immediate challenge is to verify the efficacy of the substance in in vivo experimental models of cerebral ischemia, because they have obtained good preliminar results with alive rats. Ranitidine is already widely used as a drug for treating gastric ulcers, which will accelerate the step towards clinical trials on humans. In fact, the researchers are already designing these clinical trails with associated universitary hospitals (Hospital Vall Hebron and Hospital de Sant Pau, in Barcelona).

The researchers also point out the need to work on designing new chemical compounds based on ranitidine that facilitate its administration, because the substance has difficulty moving from the blood flow to the brain. That is not an impediment in hospital interventions, as it can be administered directly to the brain, but to facilitate treatment it will be necessary to find a way in which the drug can be administered by oral route.

The following people participated in the research: Cristina Malagelada, Josefa Sabri, Jos Rodrguez, Xavier Xifr and Nahuai Badiola. They are all researchers at the Institute of Neurosciences and of the Biochemical Unit (Faculty of Medicine) of the Department of Biochemistry and of Molecular Biology at the UAB.


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Contact: Octavi Lpez Coronado
octavi.lopez@uab.es
34-93-581-3301
Universitat Autonoma de Barcelona
15-Dec-2004


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