New factor affects fertility

HOUSTON (March 16, 2005) A protein called TAF4b that helps regulate gene expression in the testis apparently affects the ability of those organs to produce and maintain levels of sperm needed for fertility in mice, according to research done by investigators at Baylor College of Medicine (BCM) in Houston.

In a report that appears today in the journal Genes & Development, Dr. JoAnne S. Richards, professor of molecular and cellular biology at BCM, and Dr. Allison E. Falender, who recently completed graduate work in Richards' lab, said that mice who lack TAF4b are fertile at first, but by 11 weeks of age become infertile and lack the precursor cells for the production of sperm.

"The fact that these animals are initially fertile indicates that the testes have the capacity to produce sperm," said Richards. "That they become infertile is related to the progressive loss of maturing germ cells in the testis."

The animals lack sperm because of defects inherent to the cells that serve as progenitors of sperm - cells that are usually found in the adult testis.

"This is the first paper to show that in the period of growth just after birth, events occur that impact fertility in the adult," said Richards. "The proliferation of germ cells is essential for fertility."

She said further study may indicate whether the loss of TAF4b also has an effect on the fertility of human men.

Falender became aware of the issue when she went to evaluate overcrowding in the mouse colony. She found that all pairs of animals that were no longer breeding had a male mouse that lacked TAF4b. When she compared the testes of these animals to those of normal mice, she found that the organs were much smaller in the mice that lacked the factor.

"That's the fun of science the unexpected that takes you somewhere exciting," said Richards.

Others who participated in the research include Drs. Kirk C. Lo and Dolores J. Lamb, both of BCM; Ric

Contact: Kimberlee Barbour
Baylor College of Medicine

Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. OHSU turns mouse into factory for human liver cells
3. Genetic factors strongly shape how peers are chosen
4. Injection drug use the most important risk factor for HIV and HCV infections among Quebec prisoners
5. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
6. New model for autism suggests women carry the disorder and explains age as a risk factor
7. Obesity found to be a risk factor for multiple myeloma
8. Journal of Alzheimers Disease achieves significant impact factor
9. Tomorrows green nanofactories
10. Study identifies a common genetic risk factor for colorectal and prostate cancer
11. Male or female factor infertility -- men suffer just the same

Post Your Comments:

(Date:7/18/2020)... ... July 16, 2020 , ... A study has ... Invictus Medical Neoasis™ active noise control device to attenuate typical noises in a ... device attenuated the alarm sounds from patient monitors, ventilators and other bedside devices ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability ... Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, ... is the most effective way to complete one? Will the study comply with ...
(Date:7/4/2020)... ... July 03, 2020 , ... ... earn outstanding recognition and multiple awards for not only the products and treatments ... SoME® Skincare and Vivace® Microneedle RF. All the brands built by ABM have ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... , ... July 08, 2020 , ... ... and products, announces a significant expansion of laboratory operations through its COVID-19 ... agencies implementing testing programs. , Bode-CARES provides a turnkey solution ...
(Date:7/10/2020)... LEXINGTON, Mass. (PRWEB) , ... July 09, 2020 ... ... novel approaches to cell therapy, today announced the hiring of Allen R. Nissenson, ... executive team and oversee the clinical development of Sentien’s lead product, SBI-101. ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... year to date growth of 40% in 2020, despite many obstacles created as ... MedShift aims to increase revenue for its partnered medical practices and medical manufacturers ...
(Date:6/28/2020)... NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... announced the launch of Safe Space™ for businesses of all types to ensure cleanliness, ... 3D LiDAR. , A Safe Space™ enabled business will provide a health ...
Breaking Biology Technology:
Cached News: