HOME >> BIOLOGY >> NEWS
New findings in innate immunity may lead to treatments for atherosclerosis

Bethesda, MD Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

The research appears as the "Paper of the Week" in the December 3 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Innate immunity is the body's first response to infection, and it plays a major role in regulating infection, inflammation, cell growth, and apoptosis. During an innate immune reaction, macrophages, dendritic cells, and epithelial cells use a set of transmembrane receptors called Toll-like receptors (TLRs) to initiate signaling cascades.

"TLRs can sense diverse environmental cues and send signals downstream to a family of interleukin-1 receptor associated kinases (IRAKs). These IRAKs then activate and/or regulate specific cytokine gene expression," explains Dr. Liwu Li of the Wake Forest University School of Medicine.

However, the specificity of the TLR signaling process is not clearly understood. "In the past," says Dr. Li, "it was thought that all IRAKs may play a somewhat redundant role in regulating the nuclear transcription factor NFκB and the expression of pro-inflammatory cytokines such as IL-1beta and TNFalpha." However, mice that lack IRAK1 can still activate NFκB, suggesting that IRAK1 may be involved in other activities.

Dr. Li and his colleagues discovered that IRAK1 actually activates a molecule called Signal Transducer and Activator of Transcription 3, or Stat3, which in turn activates expression of the anti-inflammatory cytokine IL-10. The scientists also found that IRAK1 can translocate into the nucleus and regulate the nuclear transcription of p
'"/>

Contact: Nicole Kresge
nkresge@asbmb.org
301-634-7415
American Society for Biochemistry and Molecular Biology
26-Nov-2004


Page: 1 2

Related biology news :

1. New findings challenge established views on human genome
2. New findings challenge established views about human genome
3. Depiction of findings selected as 2007 Image of the Year by Society for Nuclear Medicine
4. New findings in smell and taste
5. Study produces conflicting findings on the use of anti-anemia drug in cancer patients
6. CMU researcher publishes anole lizard findings
7. Surprising airbag hazards among research findings at hearing safety conference
8. Satellite data vital to UN climate findings
9. New findings blow a decade of assumptions out of the water
10. Cluster of journals publish findings on dangerous parasite, Toxoplasma gondii
11. New findings may lead to treatment for anxiety in Rett Syndrome

Post Your Comments:
(Date:6/18/2013)... of DNA and this modification can occur in ... now, scientists believed that this epigenetic phenomenon actively ... team of researchers from the University of Geneva ... at the Faculty of Medicine, reveals that this ... methylation may play both a passive and active ...
(Date:6/18/2013)... of Adelaide shows that weight gain and increased head size ... a higher IQ at early school age. , The study was ... from more than 13,800 children who were born full-term. , The ... that babies who put on 40% of their birthweight in the ... time they were six years of age, compared with babies who ...
(Date:6/17/2013)... with central nervous system infections may well be suffering ... to a study to be published in mBio ... for Microbiology. Researchers have detected the virus in spinal ... nervous system infections of unknown cause, and in an ... and poultry, suggesting animals may serve as reservoirs for ...
Breaking Biology News(10 mins):The secret of DNA methylation 2IQ link to baby's weight gain in first month 2New virus discovered in patients with central nervous system infections 2New virus discovered in patients with central nervous system infections 3
(Date:6/18/2013)... , June 18, 2013 ... investment research firm, announces the initiation of ... French biopharmaceutical company developing and marketing products ... indications.      (Logo: http://photos.prnewswire.com/prnh/20130417/608168) ... report examining the investment merits of BioAlliance ...
(Date:6/18/2013)... ZIONA, Israel , June 18, ... of complex bulk Active Pharmaceutical Ingredients (APIs), generic and innovative ... systems, announced today that the company has been granted a ... is indicated in the US and Europe ... US Patent number 8,410,176 B2 is titled Intermediate ...
(Date:6/18/2013)... 18, 2013 Research ... the addition of the report " DNA ... to their offering.      (Logo: ... basics of human genome variations, development of ... and small sequencers are described as well ...
(Date:6/18/2013)... Scottsdale, AZ (PRWEB) June 18, 2013 ... telemedicine services MeMD, Inc proudly announces the release ... Revolutionizing Health and Fitness ". , MeMD's goal ... the ever-changing landscape of Health 2.0, Health 3.0 ... that will likely transform medical care and the ...
Breaking Biology Technology:Edison Expands French Healthcare Sector Coverage With Initiation of Coverage on BioAlliance Pharma 2Edison Expands French Healthcare Sector Coverage With Initiation of Coverage on BioAlliance Pharma 3Mapi Pharma Granted United States Patent for Pain Relief Medication "Tapentadol" 2DNA Sequencing: Technologies, Markets and Companies - 2013 Report 2MeMD, Inc Releases Infographic Featuring the Top Eight Technologies that are Revolutionizing Health and Fitness Today 2
Cached News: