HOME >> BIOLOGY >> NEWS
New gene mutation identified in common type of dementia

ST. PAUL, MN -- Researchers have identified a new gene mutation linked to frontotemporal dementia, according to a study published in the July 10, 2007 issue of Neurology, the medical journal of the American Academy of Neurology.

Frontotemporal dementia, one form of which is known as Picks disease, involves progressive shrinking of the areas of the brain that control behavior and language. Symptoms include language problems and personality changes, often with inappropriate social behavior. Unlike Alzheimers disease dementia, the disease does not affect memory in the early stages. The genetic form of the disease is rare; most cases occur randomly.

We are hopeful that this finding will help us better understand how this disease works and eventually help us develop new therapies for the disease, said study author Amalia Bruni, MD, of the Regional Neurogenetic Centre in Lamezia Terme, Italy.

The researchers discovered a new mutation in the gene named progranulin in an extended family in southern Italy. The genealogy of this family has been reconstructed for 15 generations, going back to the 16th century; 36 family members have had frontotemporal dementia. For this study, DNA tests were conducted on 70 family members, including 13 people with the disease. This is an important result that we pursued for more than 10 years, said study co-author Ekaterina Rogaeva, PhD, with the Centre for Research in Neurodegenerative Diseases at the University of Toronto.

The mutation identified in this study is in a gene on chromosome 17. The mutation leads to a loss of progranulin, a protein growth factor that helps brain cells survive. The mutation causes only half of the protein to be produced, because only one copy of the gene is active. Production of too much progranulin has been associated with cancer.

The new gene mutation was found in nine of those family members with the disease and 10 people who are currently too young to h
'"/>

Contact: Angela Babb
ababb@aan.com
651-695-2789
American Academy of Neurology
9-Jul-2007


Page: 1 2

Related biology news :

1. Researchers identify genetic mutation that may alter tumor cell proliferation
2. p53 gene mutations and inflammation trigger skin cancer
3. Muscle weakness: New mutation identified
4. Researchers discover inherited mutation for leukemia
5. Gene mutation linked to cognition is found only in humans
6. Gene mutation linked to increased athletic performance in whippets
7. Researchers learn more about genetic mutation linked to autism
8. Researchers find gene mutation that causes infertility in male mice
9. Gene mutations linked to hereditary lung disease
10. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
11. Severe mental retardation gene mutation identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... June 25, 2019 , ... ... Using 23andMe raw data, easily available from 23andMe, customers can get access to ... service is available for both 23andMe Ancestry and Health + Ancestry customers., With ...
(Date:6/16/2019)... , ... June 14, 2019 , ... ... invited to lecture at the fifth annual Neodent World Congress. Attended by thousands ... innovative progress and latest advancements in the world of dentistry. The three-day event ...
(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly growing ... leverage the Geneious Biologics platform as a premium hub for bioinformatics and computer ... says: “The Geneious team has done an excellent job accommodating our specific data, ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... June ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... partnership agreement with Shanghai Zillion has been signed. The agreement will grant exclusive ...
(Date:6/11/2019)... CITY, Calif. (PRWEB) , ... June 10, 2019 ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to DeepDyve’s ... of physics-related content to DeepDyve’s continually expanding library of more than 20 million ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
(Date:5/31/2019)... (PRWEB) , ... May 29, ... ... our patent applications from the USPTO providing proprietary interest to our methodology, ... FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our ...
Breaking Biology Technology:
Cached News: