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New gene uncovered for late-onset Alzheimer's

SORL1 & Attributable Risk of SORL1 Variants

"Now that we know that variants in SORL1 are associated with late-onset Alzheimer's disease and we know the specific regions of the gene involved, our next step is to determine which of the variants contain the specific disease causing alteration," said Dr. Mayeux.

Another next step is to determine how many cases of late-onset Alzheimer's are caused by these SORL1 variants; it is known that ApoE4 explains approximately 20 percent of all cases of late-onset Alzheimer's. Studies are planned to investigate how many Alzheimer's cases are attributable to SORL1. The hope is that this information will help develop accurate screening for this gene.


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Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
14-Jan-2007


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