HOME >> BIOLOGY >> NEWS
New genetic findings add to understanding of OCD

Ann Arbor, Mich. -- Obsessive-compulsive disorder tends to run in families, causing members of several generations to experience severe anxiety and disturbing thoughts that they ease by repeating certain behaviors. In fact, close relatives of people with OCD are up to nine times more likely to develop OCD themselves.

Now, new research is shedding new light on one of the genetic factors that may contribute to that pattern. And while no one gene "causes" OCD, the research is helping scientists confirm the importance of a particular gene that has been suspected to play a major role in OCD's development.

In two papers published simultaneously in the Archives of General Psychiatry, researchers from the University of Michigan, the University of Illinois at Chicago, the University of Chicago and the University of Toronto report finding an association between OCD patients and a glutamate transporter gene called SLC1A1.

The gene encodes a protein called EAAC1 that regulates the flow of a substance called glutamate in and out of brain cells. So, variations in the gene might lead to alterations in that flow, perhaps putting a person at increased risk of developing OCD.

The new findings are especially important not only because of the simultaneous discoveries reported in the papers, but also because of previous studies that show a functional link between glutamate and OCD. Brain imaging and spinal fluid studies have shown differences in the glutamate system between OCD patients and healthy volunteers, including in areas of the brain where the EAAC1 protein is most common.

"Taken together, these findings suggest that SLC1A1 is a strong candidate gene for OCD, which if confirmed could lead to improvements in understanding and treating this condition, and screening those with an elevated risk," says Gregory Hanna, M.D., senior author on one of the papers and an associate professor of psychiatry at the U-M Medical School. "It
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
26-Jul-2006


Page: 1 2 3

Related biology news :

1. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
2. Does the desire to consume alcohol and tobacco come from our genetic makeup?
3. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
4. Penn researchers discover pathway that eliminates genetic defects in red blood cells
5. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
6. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
7. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
8. Identified main genetic variants involved in response to HIV
9. Restless legs genetics on the move
10. UK scientists lift lid on genetics of coronary artery disease
11. Global community listens to TAU genetic researcher at EU Conference on Hearing Loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... N.C. (PRWEB) , ... October 05, 2018 , ... ... Nutrition North America, Inc. (AHN), is announcing a 10% price increase across all ... AHN produces amino acids — the building blocks of protein — for the ...
(Date:10/5/2018)... YORBA LINDA, Calif. (PRWEB) , ... October 04, 2018 , ... ... inaccurate results of some of the tests such as cardiac troponin has serious clinical ... US population, although the exact prevalence is still unknown. , High dose of ...
(Date:10/2/2018)... GIBRALTAR, Gilbraltar (PRWEB) , ... October 02, 2018 , ... ... gaps between research, development, and access to stem cell therapy, has launched the pre-sale ... company is building a dual blockchain-based platform that will connect patients and stem cell ...
Breaking Biology News(10 mins):
(Date:10/11/2018)... ... October 11, 2018 , ... Umbilical cord ... leukemia, lymphoma, sickle cell anemia, among others, and the medical industry has been ... new e-book provides expert advice on ways to maintain the integrity and the ...
(Date:10/5/2018)... ... October 04, 2018 , ... Power T Handle, LLC, ... Award from Orthopedics This Week during the 2018 National Association of Spine Surgeons ... a surgical instrument that delivers operating room efficiencies through increased speed and reduced ...
(Date:10/5/2018)... (PRWEB) , ... October 04, 2018 , ... ... an Anacortes, Wash.-based nonprofit, with a grant to purchase a high-tech machine that ... that washes ashore in Washington State. The organization then processes the usable plastic ...
(Date:10/3/2018)... ... 2018 , ... Milwaukee Area Technical College (MATC), a public, two-year comprehensive technical ... in Room T129 in the T Building, 101 N. 6th St., to introduce area ... cutting and formal program will be held at 4 p.m. , MATC recently added ...
Breaking Biology Technology:
Cached News: