HOME >> BIOLOGY >> NEWS
New genetic link to cot death identified

Babies born with specific variants of three key genes are 14 times more likely to die from cot death, new research has found.

The findings - published in Human Immunology - build on earlier research by The University of Manchester team that had already associated one of these genes with the condition.

The discovery of two further risk genes, say the paper's authors, is a major step forward in understanding the causes of cot death or 'sudden infant death syndrome' (SIDS).

"We first identified an association between SIDS and specific variants of a gene called Interleukin-10 five years ago," said microbiologist Dr David Drucker, who led the research. "Quite simply, a baby who had particular variations of this gene was at greater risk of SIDS than other babies.

"Now, we have discovered two more genes implicated in SIDS and when a baby has certain genetic variants or 'polymorphisms' of all three of these genes he or she can be up to 14 times more likely to die from the condition."

The genes investigated by the team all play a roll in the body's immune response to infection. Previous research, carried out with colleagues at Lancaster University, had shown that SIDS is associated with commonly occurring bacteria that babies up to the age of one year may lack immunity to.

Infants aged two to four months, in particular, have very weak immune systems and may not cope well with infectious agents they encounter in their environment.

Interleukin-10 (IL-10), as well as the other two genes - Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) are involved in the production of chemicals called cytokines which are important for the correct functioning of our immune system.

Specific variants of these cytokine-producing genes, says the research, leads to an excessive inflammatory response to bacterial infection resulting in cot death. In the case of VEGF, the polymorphism associated with SID
'"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-077-178-81563
University of Manchester
24-Aug-2006


Page: 1 2

Related biology news :

1. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
2. Does the desire to consume alcohol and tobacco come from our genetic makeup?
3. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
4. Penn researchers discover pathway that eliminates genetic defects in red blood cells
5. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
6. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
7. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
8. Identified main genetic variants involved in response to HIV
9. Restless legs genetics on the move
10. UK scientists lift lid on genetics of coronary artery disease
11. Global community listens to TAU genetic researcher at EU Conference on Hearing Loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. ... of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), ... Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, ...
(Date:6/28/2020)... ... 2020 , ... In an upcoming episode scheduled for the fall of 2020, ... solutions (POCT). Check local listings for more info. , Today, the majority of testing ... to labs throughout the country. Results are then available several days later. Now, in ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SHREWSBURY, Mass. (PRWEB) , ... July 29, 2020 ... ... clad wire that can combine up to three different materials for use with ... can combine up to three materials to meet specific design requirements, performance, and ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , Gary ... in a one hour live webinar on Thursday, August 13, 2020 at ... drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing with ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World ... Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, ... an elite awards program, highlighting outstanding examples of how technology innovations and strategic ...
Breaking Biology Technology:
Cached News: