New grants bolster efforts to generate faster and cheaper tools for DNA sequencing

>Hybridization-Assisted Nanopore Sequencing

This team will work with collaborators at Brown University to develop the biochemical and algorithmic components of a method for sequencing by hybridization. By designing tagged probes and novel reconstruction algorithms, the team expects to get around the resolution limits that have prevented nanopores from being used for sequencing.

  • Robert Riehn, Ph.D., North Carolina State University, Raleigh
    $439,000 (2 years)
    Sequencing DNA by Transverse Electrical Measurements in Nanochannels

This group proposes to stretch long DNA molecules by passing them through nanofluidic channels. Nanoelectrodes will be built into those channels to detect each DNA bases specific electrical signal.

  • H. Kumar Wickramasinghe, Ph.D., University of California, Irvine
    $2,184,000 (3 years)
    High-Throughput, Low-Cost DNA Sequencing Using Probe Tip Arrays

This group has proven the feasibility of accelerating and miniaturizing the conventional Sanger method of DNA sequencing by relying on nano-scale electrophoretic separation of DNA fragments along the surface of an Atomic Force Microscope probe tip. This method reduces volume of materials, potentially accelerating and reducing the cost of sequencing. Researchers plan to demonstrate these very challenging separations and to implement them on a massively parallel sequencing platform containing hundreds of probe tips.

$100,000 Genome Grants

NHGRIs Near-Term Development for Genome Sequencing grants will support research aimed at sequencing a human-sized genome at 100 times lower cost than was possible when this initiative was announced in 2004. In part through the efforts of this NHGRI-led program, several technologies have either recently been commercialized, or are expected to be released during the next few months, that have great potential to achieve this goal. These addi

Contact: Geoff Spencer
NIH/National Human Genome Research Institute

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