HOME >> BIOLOGY >> NEWS
New insight about the source of anxiety in Rett syndrome

A peptide known to play a role in anxiety is overly plentiful in a mouse model of the inherited neurological disorder Rett syndrome and appears to underlie the anxiety-like behavior in these mice, said researchers from Baylor College of Medicine in a report that appears online in the Proceedings of the National Academy of Sciences. The finding could provide a clue to treatment for this symptom.

"This is one of the first symptoms that we can link to a molecular cause," said Dr. Huda Zoghbi, professor of pediatrics, neurology and molecular and human genetics at Baylor College of Medicine and a Howard Hughes Medical Institute investigator. "Rett affects many parts of the nervous system, and patients have many symptoms; but we don't know if they happen all at once or if there is a cascade of events."

If the latter is true, then physicians might be able to intervene by halting or limiting the effect of the first symptoms to prevent secondary effects such as those that occur due to chronic anxiety.

The mouse model of Rett was developed in Zoghbi's laboratory where scientists also found that a mutation in the gene MeCP2 (methyl-CpG-binding protein 2) causes the disorder. Between the ages of six and 18 months, children with this disease become mentally retarded, wring their hands, have difficulty walking and breathing, and suffer from anxiety. The severity of the symptoms varies with the person.

"MeCP2 is a master regulator of other genes, like a foreman in a factory," said Bryan E. McGill, a BCM M.D./Ph.D. student studying in Zoghbi's laboratory. "Considered by itself, it cannot tell you about the molecular changes that lead to the phenotype (symptoms) we see in the children. Our goal has been to find the intermediaries in the process. We want to know what other genes MeCP2 is controlling. Then we have a better understanding of the molecular basis of the phenotype we see in children."

In their work, they found that CRH (cort
'"/>

Contact: Ross Tomlin
htomlin@bcm.edu
713-798-4710
Baylor College of Medicine
13-Nov-2006


Page: 1 2

Related biology news :

1. Genomics study provides insight into the evolution of unique human traits
2. Scientists gain important insights into acute promyelocytic leukemia
3. Variant CJD -- Prion amplification breakthrough brings new insights and hopes for a blood test
4. Largest synthetic gene ever built offers insights into anti-malarial drug resistance
5. New insights into the neural basis of anxiety
6. Study of protein folds offers insight into metabolic evolution
7. From ink to optics, study of particle mixtures yields fundamental insights
8. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
9. Study of damaged gene gives insight into causes of mental illness
10. A rainbow of methods promises insights into biological processes and diseases
11. Study of planarians offers insight into germ cell development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... TORONTO (PRWEB) , ... August 13, 2019 , ... ... Cancer Medicine Team, Division of Molecular Pathology, Institute of Cancer Research (ICR) in ... (5pm BST/UK) to learn about the process of biomarker and companion diagnostic development ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... a computational modeling system that could have far-reaching implications for personalized medicine, especially ... squares regression (PLSR), is able to predict which stem cell donors and manipulation ...
(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... ... technology, is pleased to announce its attendance at the Microscopy & Microanalysis 2019 ... Portland, Oregon at the Oregon Convention Center. , The Microscopy & Microanalysis Meeting, ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... VEGAS (PRWEB) , ... July 11, 2019 , ... At ... R3 provided complimentary regenerative therapies to eight military Veterans under the R3 Heroes Program. ... being complimentary. , The R3 Heroes Program allow anyone to nominate a military Veteran, ...
(Date:7/9/2019)... ... July 08, 2019 , ... ... SmartLight Indicator was recognized as the 2019 Innovative Product of the Year which ... prestigious awards were during Sensors Expo & Conference 2019, held this ...
(Date:6/26/2019)... ... ... Alice Branton today released research results from preclinical trials on the beneficial ... prove to be beneficial for treating Hypomagnesemia. , The preclinical trial shows:, ... , Over 142% increase in particle size , Over 3% ...
(Date:6/18/2019)... POWAY, Calif. (PRWEB) , ... June 18, 2019 , ... ... submitted an Investigational New Drug (IND) application to the FDA for use of a ... stem cells as a treatment of osteoarthritis in the knee. This IND is ...
Breaking Biology Technology:
Cached News: