HOME >> BIOLOGY >> NEWS
New insights into how Huntington's disease attacks the brain

Scientific theory holds that Huntington's disease (HD) is caused by a mutant protein that arises within brain cells and kills them, triggering the genetic neurological disorder. Now a new UCLA Neuropsychiatric Institute study reveals the first strong evidence that the mutant protein also elicits toxic interactions from neighboring cells to provoke the fatal brain disorder. The May 5 edition of Neuron reports the findings.

"This is really important because most current disease models and drug development efforts rely on the assumption that Huntington's disease arises from within the target brain cells," explained Dr. William Yang, assistant professor at the UCLA Neuropsychiatric Institute and a member of the Brain Research Institute.

"Our model is the first to show that mutant HD proteins exert their influence on brain cells located near the target cells," he said. "These neighboring cells then interact with the target cells to spark disease."

To pinpoint the disorder's cellular origin, UCLA researchers developed two sets of mice with the human HD gene mutation. The first group was engineered to trigger production of the mutant HD protein throughout the brain. The second set of mice produced the mutant HD protein only in the target brain cells.

The scientists reasoned that if the mutant protein triggered the disease only from within the target cells, the second set of mice would display significant signs of the disorder. If HD required toxic interactions among cells throughout the brain, however, these same mice would show little or no signs of the disorder.

When comparing the two groups, the UCLA team discovered that the first set of mice demonstrated problems with motor control and showed visible degeneration of the target brain cells. In contrast, the second set of mice showed little signs of the disease.

"This is the first direct genetic evidence to demonstrate that abnormal interactions between cells
'"/>

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles
4-May-2005


Page: 1 2

Related biology news :

1. Scientists gain important insights into acute promyelocytic leukemia
2. Variant CJD -- Prion amplification breakthrough brings new insights and hopes for a blood test
3. Largest synthetic gene ever built offers insights into anti-malarial drug resistance
4. New insights into the neural basis of anxiety
5. From ink to optics, study of particle mixtures yields fundamental insights
6. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
7. A rainbow of methods promises insights into biological processes and diseases
8. New imaging approach promises insights into multiple sclerosis
9. Mutant mouse provides insights into breast cancer
10. From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
11. Research yields new insights into the cause of diabetes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insights into how Huntington disease attacks the brain

(Date:10/30/2014)... State University researchers have developed a suite of technologies ... and humans, which has applications in everything from search ... , "We,ve developed a platform for computer-mediated communication between ... avenues for interpreting dogs, behavioral signals and sending them ... Roberts, an assistant professor of computer science at NC ...
(Date:10/29/2014)... released by unconventional oil and gas production are well ... in the open access journal Environmental Health . ... found. The study is the first to be based ... sites and could be used to supplement official air-quality ... reserves that do not readily flow to the surface. ...
(Date:10/29/2014)... New research presented at the Society for ... TX showed for the first time that it ... using a readily available nutritional supplement, AHCC. ... Judith A. Smith, Pharm.D., associate professor in the ... The University of Texas Health Science Center at ...
Breaking Biology News(10 mins):New tech aims to improve communication between dogs and humans 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3HPV infections in women eradicated by AHCC, Japanese mushroom extract 2
(Date:10/31/2014)... Chicago, IL (PRWEB) October 30, 2014 ... tapped Insight Product Development’s decades-long heritage in successful ... real world context for what it takes to ... medical space. As part of a two-hour on-site ... University’s Kellogg school of business, McCormick School of ...
(Date:10/31/2014)... Ill. (PRWEB) October 31, 2014 Jeffrey ... Department of Historical Studies within the College of Arts ... SIUE to record the history of alcohol-based fuels in ... and many others have been working to build Illinois’ ... important but overlooked aspect of the state's agricultural and ...
(Date:10/31/2014)... 31, 2014 This is a ... China Biocides industry. The report provides basic biocides ... chain structure as well as industry overview. This ... domestic market as well as Global industry analysis ... report on the Chinese biocides industry ...
(Date:10/31/2014)... Brady (NYSE:BRC), a global leader in ... new video testimonial on the effectiveness of its ... technician at the BloodCenter of Wisconsin discusses the challenges ... hundreds of thousands of samples, and how the durability ... Brady, we design our label materials with the harsh ...
Breaking Biology Technology:Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Brady Debuts New Lab Label Testimonial Video 2
Cached News: