HOME >> BIOLOGY >> NEWS
New joint replacement material developed at MGH put to first clinical use

Massachusetts General Hospital (MGH) surgeons have performed the first total hip replacement using a joint socket lined with a novel material invented at the MGH. An advance over first-generation highly crosslinked polyethylene, which was also developed at MGH and significantly reduced a serious complication of early hip implants, the new material may be applied in replacements for a wider variety of joints in a more diverse group of patients.

We think this material could be used for any joint in the body and in any implant design, even those demanding higher flexion and more mobility, says Orhun Muratoglu, PhD, co-director of the Harris Orthopdics Biomechanics and Biomaterials Laboratory (OBBL) at MGH, who developed the new material in collaboration with scientists at the Cambridge Polymer Group.

Total replacements for hips and other joints were developed in the late 1960s, but it soon became apparent that hip implants could start loosening about 5 years after surgery and would eventually fail completely. A team led by William Harris, MD, DSc, now director emeritus of the MGH OBBL, investigated this complication and found that long-term friction of the implants head against the polyethylene-lined joint socket would break off small particles of polyethylene. The bodys immune system reacted against these foreign particles, eventually destroying adjacent bone tissue and causing the implant to loosen a condition called periprosthetic osteolysis.

Harris and his colleagues, working with polymer chemists from MIT, found that high doses of radiation would crosslink the polyethylene, bonding molecules together to produce a much more durable material. The procedure also generates free radicals that could lead to oxidization and degradation of the implant, but the research team found that melting the material would eliminate free radicals. The first-generation highly crosslinked polyethylene was approved by the FDA for use in implants
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
23-Jul-2007


Page: 1 2

Related biology news :

1. It takes a village -- female ducks negotiate joint rearing of ducklings
2. Brown and OTS will jointly manage new ILTER network secretariat
3. How movement lubricates bone joints
4. Gene therapy research switches off joint inflammation; switches on genetic process of joint repair
5. New evidence shows Rituximab halts damage to joints
6. Healthy fruits, vegetables highlight joint medical, agricultural research meet in Texas
7. Brookhaven Lab and Mount Sinai form joint Center for Translational Biomedical Imaging
8. Biodesign and TGen form joint Center for Systems and Computational Biology
9. $1 million grant from Howard Hughes Medical Institute to fund joint neuroscience program
10. Phytochemicals may protect cartilage, prevent pain in joints
11. UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New joint replacement material developed MGH put first clinical use

(Date:8/21/2014)... LAWRENCE A study recently published in the journal ... Kansas shows a new role for the protein adenomatous ... second-leading cause of cancer-related deaths in the U.S. , ... of Molecular Biosciences and co-leader of the Cancer Biology ... better part of her career trying to understand the ...
(Date:8/21/2014)... A team of researchers at Louisiana Tech ... using affordable, consumer-grade 3D printers and materials ... contain antibacterial and chemotherapeutic compounds for targeted ... doctoral students and research faculty from Louisiana ... collaborated to create filament extruders that can ...
(Date:8/21/2014)... developed a novel and versatile modeling strategy to simulate ... materials as well as for studying polyelectrolytes, including DNA ... model much larger and more complex polyelectrolyte systems, and ... lead author of a paper on the work and ... Science and Engineering. "This is a big step forward ...
Breaking Biology News(10 mins):Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Researchers develop models to study polyelectrolytes, including DNA and RNA 2
(Date:8/22/2014)... 22, 2014 Ophthalmic drug delivery ... and challenging endeavors as the anatomy, physiology and ... to the foreign substances. Ocular drug delivery technologies ... medication and minimal use of needles; also it ... and provides specific targeting within the ocular globe. ...
(Date:8/22/2014)... Nerium International, the go-to, buzzworthy ... spotlight again. Nerium will showcase its signature NeriumAD® ... Contouring Cream to Hollywood’s elite at the official ... 66th Primetime Emmy® Awards. , Developed from cutting-edge ... trials show that NeriumAD night cream dramatically reduces ...
(Date:8/21/2014)... at the Institute for Molecular Medicine Finland (FIMM), ... developed a novel "man and machine" decision support ... aid was described in PLOS One ... based on computer vision algorithms similar to those ... of only the diagnostically most relevant areas. Tablet ...
(Date:8/21/2014)... SPRING, N.Y. , Aug. 21, 2014 /PRNewswire/ ... the launch of their Nutraceutical "TELO-20 for Dogs" ... and only Telomere-lengthening supplement in the world for ... ends of every chromosome in the body. A ... world,s leading experts in Telomere Science and Aging, ...
Breaking Biology Technology:Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
Cached News: