HOME >> BIOLOGY >> NEWS
New joint replacement material developed at MGH put to first clinical use

Massachusetts General Hospital (MGH) surgeons have performed the first total hip replacement using a joint socket lined with a novel material invented at the MGH. An advance over first-generation highly crosslinked polyethylene, which was also developed at MGH and significantly reduced a serious complication of early hip implants, the new material may be applied in replacements for a wider variety of joints in a more diverse group of patients.

We think this material could be used for any joint in the body and in any implant design, even those demanding higher flexion and more mobility, says Orhun Muratoglu, PhD, co-director of the Harris Orthopdics Biomechanics and Biomaterials Laboratory (OBBL) at MGH, who developed the new material in collaboration with scientists at the Cambridge Polymer Group.

Total replacements for hips and other joints were developed in the late 1960s, but it soon became apparent that hip implants could start loosening about 5 years after surgery and would eventually fail completely. A team led by William Harris, MD, DSc, now director emeritus of the MGH OBBL, investigated this complication and found that long-term friction of the implants head against the polyethylene-lined joint socket would break off small particles of polyethylene. The bodys immune system reacted against these foreign particles, eventually destroying adjacent bone tissue and causing the implant to loosen a condition called periprosthetic osteolysis.

Harris and his colleagues, working with polymer chemists from MIT, found that high doses of radiation would crosslink the polyethylene, bonding molecules together to produce a much more durable material. The procedure also generates free radicals that could lead to oxidization and degradation of the implant, but the research team found that melting the material would eliminate free radicals. The first-generation highly crosslinked polyethylene was approved by the FDA for use in implants
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
23-Jul-2007


Page: 1 2

Related biology news :

1. It takes a village -- female ducks negotiate joint rearing of ducklings
2. Brown and OTS will jointly manage new ILTER network secretariat
3. How movement lubricates bone joints
4. Gene therapy research switches off joint inflammation; switches on genetic process of joint repair
5. New evidence shows Rituximab halts damage to joints
6. Healthy fruits, vegetables highlight joint medical, agricultural research meet in Texas
7. Brookhaven Lab and Mount Sinai form joint Center for Translational Biomedical Imaging
8. Biodesign and TGen form joint Center for Systems and Computational Biology
9. $1 million grant from Howard Hughes Medical Institute to fund joint neuroscience program
10. Phytochemicals may protect cartilage, prevent pain in joints
11. UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... Paramus, New Jersey (PRWEB) , ... September 21, ... ... for highly-regulated pharmaceutical and clinical research sector professionals, has announced the addition of ... CFR Part 11 training - Compliance with Regulation 21 CFR Part 11 ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... has appointed Vishwas Paralkar to the role of chief scientific officer. In this ... will report to Cybrexa’s president and CEO, Per Hellsund. , “I was impressed ...
(Date:9/20/2017)... Dallas-Fort Worth, Texas (PRWEB) , ... September 20, 2017 , ... ... people, stem cell therapy succeeded after standard medicine failed. Many of these people had ... - Progress, Not Regression Free Download (pdf) , “Neil ...
(Date:9/19/2017)... ... September 19, 2017 , ... A ... funded early-stage tech companies. “Grit” author Angela Duckworth and her team at Character ... community is Cooley, an international law firm with decades of experience supporting high-growth ...
Breaking Biology Technology:
Cached News: