The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
New molecular regulators of hyperthyroidism and goiter

The thyroid gland has an important role in determining how much energy the body burns. Thyroid gland functions are regulated by a hormone known as thyroid-stimulating hormone (TSH). Increased levels of TSH, as well as increased signaling through the receptor for TSH, result in hyperthyroidism (characterized by weight loss because the body increases the amount of energy it burns) and goiter.

Signals downstream of the receptor for TSH had been thought to be mediated mainly by a protein complex known as Gs. But now, a study that appears online on August 9, in advance of publication in the September print issue of the Journal of Clinical Investigation, indicates that in mice Gq/G11-mediated signaling has an essential role in transmitting TSH-induced signals and therefore in regulating thyroid gland function. This makes Gq and G11 potential new targets for the treatment of hyperthyroidism and goiter.

In the study, Stefan Offermanns and colleagues from the University of Heidelberg, Germany, generated mice lacking the alpha-subunits of both Gq and G11 only in cells of the thyroid gland. These mice had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In addition, the thyroid gland in these mice was unresponsive to the proliferative effects of TSH and a goitrogenic diet. The authors therefore suggest that inhibiting Gq and G11, or the molecules activated downstream of these G proteins, might be of therapeutic benefit for individuals with diseases characterized by increased thyroid gland function and/or growth.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
9-Aug-2007


Page: 1

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. A novel molecular dictator with a conscience discovered
3. UC Santa Barbara scientists clarify molecular basis of interferon action
4. MU researchers make discovery in molecular mechanics of phototropism
5. Malaria-resistant mosquitoes battle disease with molecular warhead
6. University of Cincinnati receives $1.7M to research molecular treatment of brain injury
7. Casting the molecular net
8. Tumor vessels identified by unique molecular markers
9. SNM advances professional definition for molecular imaging
10. Uncovering the molecular basis of obesity
11. Combining molecular imaging technologies to stop/prevent heart attacks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New molecular regulators hyperthyroidism and goiter

(Date:11/23/2009)...tal irritants such as air pollution and cigarette ... today in the American Journal of Respiratory and..., from Imperial College London and the University ...ungs that can trigger coughing when a person is ex...gest that their findings may ultimately lead to th...
(Date:11/23/2009)... , A bit of imagination on the part of a measur...elp to add data from areas where the instrument is...ctively. In order to infer missing data in an astr...on, physicists at the Max Planck Institute for Ast...eption called information field theory. The scient...
(Date:11/23/2009)..., Not just birds, but also a few species of ba...Princeton University in the U.S. and at the Max Pl...any studied the migratory behaviour of the largest...nidae" with the help of mathematical models. They ...s long distances of various kinds of bats evolved ...
Breaking Biology News(10 mins):Research reveals exactly how coughing is triggered by environmental irritants 2Visual assistance for cosmic blind spots 2Visual assistance for cosmic blind spots 3Visual assistance for cosmic blind spots 4We're off then: The evolution of bat migration 2Congress Breathes Easier Thanks to Speaker Pelosis Successful Efforts to Eliminate House Smoking Rooms 57368 1Congress Breathes Easier Thanks to Speaker Pelosis Successful Efforts to Eliminate House Smoking Rooms 57368 2FDA Requires Boxed Warning for Promethazine Hydrochloride Injection 57364 1FDA Requires Boxed Warning for Promethazine Hydrochloride Injection 57364 2Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 14098 1Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 14098 2Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 14098 3Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 14098 4
(Date:11/23/2009)... CHAMPAIGN, Ill. You can think of it as origami ...ersity of Illinois have developed a technique for ...silicon structures from thin films by coupling pho... capillary interactions. , The films, only a few ...s not possible with thicker pieces of the same mat...
(Date:11/23/2009)..., MISSISSAUGA,ON,Nov.23/PRNewswire-FirstCall/...encesproductdevelopmentcompanythatidentifiesandadv...ductsatvariousstagesofdevelopment,todayreportedtha...ItrialevaluatingCYT387,apotent,orally-administered...linicinRochester,Minnesota.AproposaltomergeCytopia...
(Date:11/23/2009)..., BURNABY,BC,Nov.23/PRNewswire/-InimexPharmac...elJ.Abrams,Ph.DasitsPresidentandCEO. ,, Abramsb...xperiencetoInimex.Heisaco-inventorofthenuclearmedi...6atJohnsonMatthey,plcwherehewasManager,BiomedicalR...fAnorMEDinLangley,BCandwasPresidentandCEOfrom1996t...
(Date:11/20/2009)... , , , , , , , , , ... , , AUDIO: , A team of scienti...niversity of Arizona, Cold Spring Harbor Laborator...g the DNA of corn. The... , , Cli... , , , , , , , ...
Breaking Biology Technology:Water droplets direct self-assembly process in thin-film materials 2YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 2YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 3YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 4Inimex Announces Appointment of New CEO 2Amaizing: Corn genome decoded 2Amaizing: Corn genome decoded 3Amaizing: Corn genome decoded 4
Other News:
... of scientists from Harbor Branch and other instit...ales from the deep after completing their second a...red a mysterious visual capability in a deep-sea c...vered squid species; and took clear video of the w...
...Interuniversity Institute for Biotechnology (VIB) ...hepatitis. The researchers, connected to Ghent Uni...e most important proteins involved in hepatitis. U...in prevents inflammation of the liver as well as t...
ANN ARBOR, Mich. Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely painful. ....
...vessels grow into it. But the cornea is typically...e September 1 print issue of The Journal of Clinic...om the Schepens Eye Institute examine which cells .... The authors find that innate immune cells, in p...
Deep-sea exploration beneath Katrina's wake 2Deep-sea exploration beneath Katrina's wake 3Deep-sea exploration beneath Katrina's wake 4A new player in the battle against hepatitis prevents inflammation and the death of liver cells 2Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors 2Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors 3
...YORK April 8, 2003 The options for treating advan...he patient is a dog or a human. Because this deadl...d radiation in its late stages, new approaches are...s the immune system. For nine dogs that naturally ...
...ent by Ronald Cole-Turner: ......The article by Ge... Science suggests that primate cloning may be diff...ive embryonic stem cells, and much more if the goa...cations of this work for ethics and public policy?...
...ON In working to halt the overgrowth of blood ves...c molecules endostatin and tumstatin take two dist...udy in the April 15 issue of the Proceedings of th...dings, which currently appear on-line, suggest for...
Ecological impacts from roads may be the rule rather than the exception for most of the U.S., according to a USDA Forest Service researcher. For an article in the April issue of Frontiers in Ecology a
DNA-based vaccine triples survival for dogs with melanoma 2Difficulties with primate cloning: A religious comment 2Study offers new insights into angiogenesis inhibitors 2How far to the nearest road? 2