HOME >> BIOLOGY >> NEWS
New mouse model closely mimics human cancers

BOSTON--A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

Ronald A. DePinho, MD, of Dana-Farber has created mice that form tumors that are more genetically complex and unstable -- and therefore a better stand-in for human cancers -- than those of conventional genetically engineered mouse models of cancer. To characterize these mouse tumors, DePinho collaborated with Lynda Chin, MD, also at Dana-Farber, to perform high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

The report has been posted as an advanced online by the journal Nature and will appear in a forthcoming print version.

The scientists, working with a large dataset generated by the Chin laboratory during the past several years, compared the patterns of these chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

The comparisons showed that genetic instability in the mouse cancer cells caused DNA alterations that in many cases were identical to such changes in human tumors. This match up, said the researchers, suggested that the new mouse model may be useful in guiding the search for genes that are important for cancer growth. To that end, it may facilitate research associated with the National Institutes of Health-funded Human Cancer Genome Atlas Project, which involves sifting the entire human DNA and identifying the immensely complicated, interacting molecular changes that initiate and maintain tumors.

"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passe
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
24-May-2007


Page: 1 2 3

Related biology news :

1. OHSU turns mouse into factory for human liver cells
2. Virtual mouse brains now available online
3. New approaches to endometriosis treatment -- mouse experiments point the way
4. Statin treatment improves spatial memory in mouse models of Alzheimers
5. Treatment extends survival in mouse model of spinal muscular atrophy
6. UCSF stem cell study reveals cells capability in mouse brain tissue repair
7. Mutant mouse provides insights into breast cancer
8. Mapping the mouse genome
9. MRSA vaccine shows promise in mouse study
10. Researchers create mouse lacking key inflammation gene
11. U of MN researchers develop mouse model for muscle disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/1/2019)... ... March 01, 2019 , ... Geneious would like to announce it ... alternative to Vector NTI. , Geneious Prime already has a dedicated importer for ... NTI, so that files will be organised in Geneious in the same way. ...
(Date:2/27/2019)... (PRWEB) , ... February 26, 2019 , ... Circulomics is ... high molecular weight (HMW) DNA for long-read sequencing library preparation. , This kit ... The gentle processing ensures that HMW DNA is not damaged and recovered with high ...
(Date:2/22/2019)... ... February 20, 2019 , ... As technology ... the traditional line between engineering and medical science grows ever thinner. As medical ... medical device industry is making medical practice easier for doctors, more effective for ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... SAN JOSE, Calif. (PRWEB) , ... March 19, ... ... provider of multi-GPU deep learning cloud solutions, today announced it has extended its ... partnerships with several key colocation data centers that are part of the NVIDIA ...
(Date:3/19/2019)... ... March 19, 2019 , ... ... cloud solutions, today announced it has begun offering NVIDIA® DGX-1™ deep learning systems ... utilize DGX-1, designed to provide the highest performance for artificial intelligence and deep ...
(Date:3/14/2019)... (PRWEB) , ... March 14, 2019 , ... ... Annual Conference & Expo, themed “Navigating the Full Spectrum of Case Management,” continues ... June 10-14, 2019. This conference is the only case management industry conference serving ...
(Date:3/12/2019)... (PRWEB) , ... March 11, 2019 , ... ... first hospital system in Colorado, and among the first in the nation, to ... around lab draws, IV placement and overall degree to which staff showed compassion ...
Breaking Biology Technology:
Cached News: