HOME >> BIOLOGY >> NEWS
New mouse model closely mimics human cancers

BOSTON--A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

Ronald A. DePinho, MD, of Dana-Farber has created mice that form tumors that are more genetically complex and unstable -- and therefore a better stand-in for human cancers -- than those of conventional genetically engineered mouse models of cancer. To characterize these mouse tumors, DePinho collaborated with Lynda Chin, MD, also at Dana-Farber, to perform high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

The report has been posted as an advanced online by the journal Nature and will appear in a forthcoming print version.

The scientists, working with a large dataset generated by the Chin laboratory during the past several years, compared the patterns of these chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

The comparisons showed that genetic instability in the mouse cancer cells caused DNA alterations that in many cases were identical to such changes in human tumors. This match up, said the researchers, suggested that the new mouse model may be useful in guiding the search for genes that are important for cancer growth. To that end, it may facilitate research associated with the National Institutes of Health-funded Human Cancer Genome Atlas Project, which involves sifting the entire human DNA and identifying the immensely complicated, interacting molecular changes that initiate and maintain tumors.

"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passe
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
24-May-2007


Page: 1 2 3

Related biology news :

1. OHSU turns mouse into factory for human liver cells
2. Virtual mouse brains now available online
3. New approaches to endometriosis treatment -- mouse experiments point the way
4. Statin treatment improves spatial memory in mouse models of Alzheimers
5. Treatment extends survival in mouse model of spinal muscular atrophy
6. UCSF stem cell study reveals cells capability in mouse brain tissue repair
7. Mutant mouse provides insights into breast cancer
8. Mapping the mouse genome
9. MRSA vaccine shows promise in mouse study
10. Researchers create mouse lacking key inflammation gene
11. U of MN researchers develop mouse model for muscle disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/20/2018)... ... November 20, 2018 , ... Like many large breed ... Before he was a year old, his mom, Rebecca, noticed he was slow ... examined by her veterinarian and her suspicions were confirmed: Jack had bilateral hip dysplasia, ...
(Date:11/16/2018)... ... November 16, 2018 , ... Earthres ... the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby Advocacy Award at the IBWA ... named “The Selby” after longtime IBWA contributor Shayron Barnes-Selby, is awarded to an ...
(Date:11/15/2018)... ... November 15, 2018 , ... Superior Controls, Inc. ... solutions with 140 employees on both the east and west coasts, today announced ... Certification. CSIA Certified control system integrators must pass an intensive audit every three ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... (PRWEB) , ... December 12, 2018 , ... Helping conclude ... their new sleek and slim hearing aid within its Vision and Hearing campaign that ... loss. , Studies show that despite continued efforts to destigmatize hearing aids over ...
(Date:12/5/2018)... ... 05, 2018 , ... STRmix™ – sophisticated forensic software capable of resolving mixed ... to convict a Wyoming man of third-degree sexual assault, a felony punishable by imprisonment ... for DNA on the couch cushions on which the sexual assault was alleged to ...
(Date:11/26/2018)... (PRWEB) , ... November 26, 2018 , ... ... company backed by Siemens Healthineers and Omphalos Venture Partners (Virtual Radiologic founders) among ... Annual Meeting from Nov. 25-29 at McCormick Place in Chicago. The company is ...
(Date:11/15/2018)... ... November 14, 2018 , ... Hüpnos announces the ... the public. It is estimated that 90 million Americans suffer from ... partner. The resulting daytime fatigue causes extreme difficulty with concentration, focus and memory. ...
Breaking Biology Technology:
Cached News: