HOME >> BIOLOGY >> NEWS
New mouse model closely mimics human cancers

BOSTON--A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

Ronald A. DePinho, MD, of Dana-Farber has created mice that form tumors that are more genetically complex and unstable -- and therefore a better stand-in for human cancers -- than those of conventional genetically engineered mouse models of cancer. To characterize these mouse tumors, DePinho collaborated with Lynda Chin, MD, also at Dana-Farber, to perform high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

The report has been posted as an advanced online by the journal Nature and will appear in a forthcoming print version.

The scientists, working with a large dataset generated by the Chin laboratory during the past several years, compared the patterns of these chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

The comparisons showed that genetic instability in the mouse cancer cells caused DNA alterations that in many cases were identical to such changes in human tumors. This match up, said the researchers, suggested that the new mouse model may be useful in guiding the search for genes that are important for cancer growth. To that end, it may facilitate research associated with the National Institutes of Health-funded Human Cancer Genome Atlas Project, which involves sifting the entire human DNA and identifying the immensely complicated, interacting molecular changes that initiate and maintain tumors.

"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passe
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
24-May-2007


Page: 1 2 3

Related biology news :

1. OHSU turns mouse into factory for human liver cells
2. Virtual mouse brains now available online
3. New approaches to endometriosis treatment -- mouse experiments point the way
4. Statin treatment improves spatial memory in mouse models of Alzheimers
5. Treatment extends survival in mouse model of spinal muscular atrophy
6. UCSF stem cell study reveals cells capability in mouse brain tissue repair
7. Mutant mouse provides insights into breast cancer
8. Mapping the mouse genome
9. MRSA vaccine shows promise in mouse study
10. Researchers create mouse lacking key inflammation gene
11. U of MN researchers develop mouse model for muscle disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2020)... ... May 06, 2020 , ... Sickle Cell Disease Association of America, ... dedicated to improving the quality, safety, efficacy and cost of red blood cell (RBC) ... on its mission and meet its goals. In 2020 Hemanext will collaborate with SCDAA ...
(Date:5/1/2020)... (PRWEB) , ... May 01, 2020 , ... More than ... Comprehensive Cancer Center’s High-Risk Cancer Program, which is led by two genetic counselors. , ... solutions, today announced it is teaming up with UConn’s High Rick Program to ensure ...
(Date:4/26/2020)... ... April 23, 2020 , ... SECO , a ... Tech Growth managed by Fondo Italiano d’Investimento SGR, today announced a partnership with ... of Respira, a new non-invasive pulmonary ventilator created in response to the current ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... WESTBURY, N.Y. (PRWEB) , ... May 14, 2020 , ... ... to get unforeseen and the most pressing questions answered quickly as the need arises. ... compliance-related topics, offering valuable advice at affordable rates. , Lachman OnCall™ SMEs are ...
(Date:5/14/2020)... SAN FRANCISCO (PRWEB) , ... May 13, 2020 ... ... new content hub called Future Lab: Optimizing Workflows in the Life Science ... them optimize workflows in their lab, from water purification and liquid handling to ...
(Date:5/5/2020)... ... May 05, 2020 , ... ProductLife Group has marked ... Duburcq joins the group after 13 years at Altran, where he was Group VP ... in Immunology and being a Pharmacist, Xavier was involved in his early career in ...
(Date:4/23/2020)... Va. (PRWEB) , ... April 22, 2020 , ... ... essential equipment for healthcare providers to protect themselves from COVID-19. Virginia has only ... from the Federal Emergency Management Association (FEMA). , As Governor Northam told the ...
Breaking Biology Technology:
Cached News: