HOME >> BIOLOGY >> NEWS
New paradigm will help identify leads for drug discovery

Bethesda, Md., Mon., July 24, 2006 -- A new screening approach can profile compounds in large chemical libraries more accurately and precisely than standard methods, speeding the production of data that can be used to probe biological activities and identify leads for drug discovery, the National Institutes of Health (NIH) Chemical Genomics Center, part of the NIH Roadmap for Medical Research's Molecular Libraries and Imaging Initiative, reported today.

"We are excited by the power of this approach, developed through the NIH Roadmap for Medical Research, to generate new chemical 'tools' for biological exploration. These tools will help researchers in both the public and private sectors unlock the mysteries of gene function and signaling pathways throughout the human body, opening the door to the development of new drugs," said NIH Director Elias A. Zerhouni, M.D.

In a paper published online in the Proceedings of the National Academy of Sciences (PNAS), a team from the NIH Chemical Genomics Center demonstrates the feasibility of a new paradigm for profiling every compound in large collections of chemicals. Traditional high-throughput screening measures the biological activity of chemical compounds at just one concentration. In contrast, the new approach, called quantitative high-throughput screening, or qHTS, tests the biological activity of chemical compounds at seven or more concentration levels spanning four orders of magnitude. The multi-concentration screen produces a pharmacological characterization of all the compounds that is far more complete and reliable than traditional methods.

"This advance is crucial to NIH's goal of efficiently profiling the range of biological activities associated with large chemical libraries and making that data swiftly available to the worldwide research community," said Francis S. Collins, M.D., Ph.D., director of the National Human Genome Research Institute (NHGRI). "Broad adoption of this para
'"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
24-Jul-2006


Page: 1 2 3 4

Related biology news :

1. Do we need a paradigm change? Disputing coevolution in herbivorous insects
2. Protein splicing upsets the DNA colinearity paradigm
3. Researcher predicts paradigm shift in heart disease treatment
4. Yale book offers new paradigm for building design
5. Navigating the brain for sense of direction as paradigm for higher cognitive functions
6. Ethical paradigm: Relating embryonic stem cell use to organ donation
7. Research aims to identify markers for menopausal women at risk for deadly blood clot
8. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
9. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
10. U-M researchers identify gene involved in breast cancer
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... ROSKILDE, Denmark and RALEIGH, N.C. (PRWEB) , ... ... ... leader in micro acoustic and micro mechanical technologies and solutions for hearing instruments ... sensor technology, today announced BiometRIC, the first ever hearing aid receiver in canal ...
(Date:1/4/2019)... ... January 02, 2019 , ... Lifecycle Biotechnologies announces ... life science tools and service supplier turned 40 in 2018 and for the ... features not just part numbers like most catalogs, but rather, insightful information into ...
(Date:12/27/2018)... FRANCISCO (PRWEB) , ... December 27, 2018 , ... ... annual Microbiome Conference at JPM as part of the JP Morgan 37th Annual ... innovative scientists and physicians, and members of the investment community. , Since ...
Breaking Biology News(10 mins):
(Date:12/10/2018)... ... December 10, 2018 , ... ... Contract Development and Manufacturing Organization (CDMO) with sites in China and the ... manufacturing, and aseptic fill finish solutions for monoclonal antibody (mAb) and antibody-drug ...
(Date:12/5/2018)... ... ... The incredible life story of former refugee and LG Sonic CEO Yousef ... the European Commissioner for Research and Innovation. , In his November 27th speech ... spoke at length of Yousef’s life and journey, citing the man who convinced him ...
(Date:12/5/2018)... Va. and LONDON (PRWEB) , ... ... ... Research Group (ARG), an established North American full-service contract research organization (CRO), ... Effective immediately, the transaction significantly strengthens ARG’s reach and experience in the ...
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's ... as well as experience the height of truffle season. , Her first ... pristine countryside. Staying in the exclusive Black Truffle Lodge in the small mountain village ...
Breaking Biology Technology:
Cached News: