HOME >> BIOLOGY >> NEWS
New research bolsters highly targeted gastro-intestinal cancer treatment

Leuven, Belgium - Gastro-Intestinal Stroma Tumor (GIST) is a rare form of cancer of the stomach or small intestine. Up to now, only one effective treatment has existed for GIST: the use of Glivec. However, over time, this remedy becomes ineffective for a large percentage of the patients. Along with colleagues in Leuven, the research group of Peter Marynen of the Flanders Interuniversity Institute for Biotechnology (VIB), connected to the Catholic University of Leuven, has uncovered the process underlying the frequent ineffectiveness of Glivec. In addition, the researchers have shown that PKC412 - an experimental drug currently in the second phase of clinical research - can be effective in helping these patients once again. This possible alternative to Glivec, and the genetic understanding of the development of resistance to Glivec, should make it possible to prescribe a new highly targeted therapy for patients in the future.

GIST: a specific form of gastro-intestinal cancer
GIST is a rare form of gastro-intestinal cancer that strikes some 175 Belgians each year. Often, by the time it is discovered, there are already metastases in other organs, which make it impossible to remove the GIST tumors surgically. Furthermore, the other traditional cancer treatments - chemotherapy and radiation treatment - produce little result. Since 2002, there has been an effective treatment for GIST: Glivec. And up to now, this has been the only remedy for treating GIST effectively.

Why look for an alternative for Glivec?
To arrive at a definite diagnosis for GIST, a biopsy is needed to verify the presence of specific receptor proteins on the GIST cells. Cells contain certain receptors to which growth factors can bind, but GIST cells contain a defect in one of these receptors, the KIT receptor. The defective KIT receptor gives a continuous signal to the cancer cells to multiply, enabling the cancer cells to grow irrespective of the presence of th
'"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
32-9-244-6611
VIB, Flanders Interuniversity Institute of Biotechnology
6-Jul-2005


Page: 1 2

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. Saudi Arabias KAUST names WHOI first research partner
3. Multinational research: protecting ecology means understanding people, too
4. Newly created cancer stem cells could aid breast cancer research
5. Carnegie Mellons Peter Adams receives EPA research grant
6. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
7. Innovative tagging technique may help researchers better protect fish stocks
8. Penn researchers discover how key protein stops inflammation
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... ... treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan ... Drug Discovery. , Dr. Canan previously served as Executive Director of Global Health ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, ... magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ranking of ... as well, and for this year’s list, reported three-year revenue growth of 71 percent. ...
(Date:8/21/2020)... CARLSBAD, Calif. (PRWEB) , ... August 19, 2020 ... ... of both Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for ... co-editor of the recently published book by Springer, " Salivary Bioscience: Foundations of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Texas (PRWEB) , ... July 29, 2020 , ... ... solutions today announced the launch of its new tagline, “BUILDING FOR LIFE.” The ... biopharmaceutical industry and around the globe, requiring fast track capacity to provide patients ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet ... to three different materials for use with CRM, neurostimulation, vascular, and related devices. ... to meet specific design requirements, performance, and cost criteria; especially where solid wire ...
(Date:7/31/2020)... ... 2020 , ... eSource has long been touted as the solution to high ... eSource, the reasons it did not take off as quickly as people initially expected, ... is moving towards capturing data electronically for clinical trials and then repurposing it for ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... today announced the release of its signature product called Beacon - a ... and other field medical professionals. , Beacon helps MSLs streamline communication ...
Breaking Biology Technology:
Cached News: