HOME >> BIOLOGY >> NEWS
New research holds promise for protecting cancer patients against infertility

Lyon, France: A promising new therapy for protecting the fertility of women with cancer and auto-immune diseases such as lupus was revealed at the 23rd annual conference of the European Society of Human Reproduction and Embryology today (Tuesday 3 July 2007). Dr. Kate Stern, Research Director of the Royal Womens Hospital, Melbourne, Australia, told the conference that her pilot study had shown gonadotropin-releasing hormone (GnRH) antagonists were likely to be able to protect the ovary in women receiving potentially toxic doses of chemotherapy. We are now hoping to carry out a randomised controlled trial to assess the long term protective effect of this treatment, she said

GnRH analogues are commonly used in the management of womens disorders that are dependent on oestrogen production, and in IVF therapies. Dr. Stern and her team studied women between the ages of 18 and 35 years who were due to receive high doses of cyclophosphamide, a chemotherapy drug. They knew that GnHR analogues were already used for the temporary suppression of ovulation in infertility treatment, so reasoned that it would be possible to use it to shut down the ovaries temporarily during the time that chemotherapy was administered, and hence protect them from the effect of the drugs.

The women were given the GnRH antagonist cetrorelix by 3 subcutaneous injections, each of them four days apart, concurrently with their chemotherapy. The scientists observed that there was evidence that ovarian function was suppressed, but that this returned to normal after chemotherapy stopped. Follicle stimulating hormone levels were up in 73% of the patients, but these also subsequently returned to normal. 94% of the patients resumed spontaneous ovulation and menses within 12 months.

We believe that using GnRH antagonists in this way could reduce the side effects of chemotherapy over a long period, said Dr. Stern. Other studies have tried to analyse whether sim
'"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
3-Jul-2007


Page: 1 2

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. Saudi Arabias KAUST names WHOI first research partner
3. Multinational research: protecting ecology means understanding people, too
4. Newly created cancer stem cells could aid breast cancer research
5. Carnegie Mellons Peter Adams receives EPA research grant
6. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
7. Innovative tagging technique may help researchers better protect fish stocks
8. Penn researchers discover how key protein stops inflammation
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2019)... ... ... January has been a record-breaking month so far for Lajollacooks4u, San Diego’s premiere ... several of its signature cooking classes and team-building events, but it is also gearing ... , Since 2008, Lajollacooks4u’s team-building events have been a favorite for companies of all ...
(Date:1/20/2019)... , ... January 18, 2019 , ... Boston-based Laboratory as ... in an effort to better express its continued expansion and service offerings for ... for a new kind of lab: one that is more agile and adaptable than ...
(Date:1/14/2019)... ... January 14, 2019 , ... Join the ... GMT) to hear about key topics in data quality, including:, ...     Patient engagement ,     Smartphone and wearable based performance measures , ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... ... January 17, 2019 , ... Consumers are directing healthcare in ... physicians. That's changing as many services now exist for patients to order tests ... totaled $208 million in 2018, according to Kalorama Information’s new report, The ...
(Date:1/20/2019)... ... January 17, 2019 , ... TrakCel, the leading ... The Quick Life Science Group (Quick Healthcare and QuickSTAT) today announce a partnership ... global cell and gene therapy industry to track products and manage the logistical ...
(Date:1/11/2019)... ... January 11, 2019 , ... ... for the automated collection of donor blood. This advanced and intuitive medical ... The unit incorporates the functionality needed for the busiest donor stations with new-to-the ...
(Date:1/10/2019)... ... January 08, 2019 , ... ... announced today that SAGICO will be represented at the 37th Annual J.P. ... Healthcare Conference is the largest and most informative healthcare investment symposium in ...
Breaking Biology Technology:
Cached News: