HOME >> BIOLOGY >> NEWS
New research identifies anti-viral protein that may predict who might be at risk to develop lupus

Certain families produce higher levels of a specific molecule, called interferon-alpha, that primes the bodys immune system to turn on, and in some cases initiate an autoimmune attack on itself, according to new research from Hospital for Special Surgery in New York City.

Our immune system is able to defeat disease-causing viruses and bacteria every day using chemical weapons, like interferon-alpha, that have been honed over time. But like anything else, we can have too much of a good thing.

Using blood samples from two large repositories, rheumatologist Mary K. Crow, M.D., and her colleagues at Hospital for Special Surgery compared 266 patients with systemic lupus erythematosus (SLE), an autoimmune disease, with 405 of their healthy relatives. Specifically, Dr. Crow, who is director of Rheumatology Research and associate chief of the Division of Rheumatology at Hospital for Special Surgery, and her team were looking at levels of interferon-alpha. The researchers found that when an SLE patient had high blood levels, so did many of their healthy first degree family members. There was a genetic link.

The study, which is now online in advance of print, will be in the September issue of Genes and Immunity.

There were a number of first degree relatives of patients with SLE that had high interferon-alpha levels, says Timothy Niewold, M.D., first author of the study and a former rheumatology fellow at Hospital for Special Surgery. But otherwise, those family members looked and felt perfectly fine. All of their diagnostics were normal.

Our immune system works by distinguishing self from non-self, so that it preferentially attacks foreign microbes. Interferon-alpha is normally a helpful molecule in this regard, leading the fight against invading viruses. Genes producing high levels of interferon-alpha have probably been selected over time to help fight infection. But high levels of interferon-alpha in some individuals ma
'"/>

Contact: Tracy Hickenbottom
hickenbottomt@hss.edu
212-606-1197
Hospital for Special Surgery
27-Jul-2007


Page: 1 2 3

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. Saudi Arabias KAUST names WHOI first research partner
3. Multinational research: protecting ecology means understanding people, too
4. Newly created cancer stem cells could aid breast cancer research
5. Carnegie Mellons Peter Adams receives EPA research grant
6. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
7. Innovative tagging technique may help researchers better protect fish stocks
8. Penn researchers discover how key protein stops inflammation
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/23/2017)... March 23, 2017 The report "Gesture Recognition and Touchless ... and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is ... of 29.63% between 2017 and 2022. Continue Reading ... ... ...
(Date:3/20/2017)... , March 20, 2017 At this year,s CeBIT ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together ... is this year,s CeBIT partner country. At the largest German biometrics company ... use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 22, 2017 , ... A new ... San Diego, California, this August will feature high-level speakers on quantum devices, graphene ... SPIE Optics and Photonics, the largest multidisciplinary optical sciences meeting in North America, ...
(Date:5/23/2017)... ... May 23, 2017 , ... Energetiq Technology, a world ... facility expansion to accommodate its rapid growth. , The renovations at the company’s ... of the existing areas. The expansion includes, a state-of-the-art engineering facility, and a ...
(Date:5/23/2017)... ... ... Bacterial biofilms, surface adherent communities of bacteria that are encased in a ... and catheter infections to gum disease and the rejection of medical implants. Though ... year, there is currently a paucity of means for preventing their formation or treating ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... to re-engineer their control technology again and again. METTLER TOLEDO has released two ... manufacturers. The videos illustrate how integration of the ACT350 into Siemens and Allen ...
Breaking Biology Technology:
Cached News: