HOME >> BIOLOGY >> NEWS
New research identifies anti-viral protein that may predict who might be at risk to develop lupus

y also confuse the immune system so that it doesnt know self from non-self anymore turning and attacking its own tissue as in SLE.

As far back as the 1970s, doctors had known that a characteristic of patients with SLE, who are mainly women in their childbearing years, was an abnormally high blood level of interferon-alpha. However, they didnt know if the high interferon levels were the cause of the disease or just an associated side-effect.

A role for interferon-alpha in lupus has been suggested for a number of years, says Dr. Crow, who is also director of the Autoimmunity and Inflammation Research Program and co-director of the Mary Kirkland Center for Lupus Research at Hospital for Special Surgery. However, all of the studies to date had focused on how the levels of interferon-alpha were controlled and what the effects of such high levels were. The real question was whether interferon-alpha was playing a primary role in the disease or not.

The blood samples showed that some family members of patients with high levels of interferon-alpha also had higher levels than unrelated healthy individuals, irrespective of their ethnic background. This observation supported the idea that high interferon-alpha levels play an important primary role in the disease.

Next, the researchers examined the samples for two types of autoantibodies common to SLE patients. SLE patients with low levels of interferon-alpha were more likely to have neither of the characteristic autoantibodies, while patients with the highest levels were more likely to have both. However the healthy family members with high interferon-alpha did not have either autoantibody. This led the scientists to propose a two-hit model for the development of lupus. Genetics that cause high levels of interferon-alpha may predispose a person to SLE, but the disease appears only when something else, perhaps an environmental factor, pushes the immune system to the breaking point and
'"/>

Contact: Tracy Hickenbottom
hickenbottomt@hss.edu
212-606-1197
Hospital for Special Surgery
27-Jul-2007


Page: 1 2 3

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. Saudi Arabias KAUST names WHOI first research partner
3. Multinational research: protecting ecology means understanding people, too
4. Newly created cancer stem cells could aid breast cancer research
5. Carnegie Mellons Peter Adams receives EPA research grant
6. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
7. Innovative tagging technique may help researchers better protect fish stocks
8. Penn researchers discover how key protein stops inflammation
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
(Date:10/9/2017)... Charlotte, N.C. (PRWEB) , ... October 09, 2017 , ... ... Purple announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and ... Dr. Stubbs was a member of the winning team for the 2015 Breakthrough Prize ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers ... perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the leading ... around the world, is giving back to cancer research with a month-long promotion supporting ... Now through October 31, shoppers can use promo code PinkRibbon to get 10 percent ...
Breaking Biology Technology:
Cached News: