HOME >> BIOLOGY >> NEWS
New role for protein in fat cells may improve understanding of obesity and diabetes

Bethesda, Md. -- Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat. Richard E. Morton and Lahoucine Izem, research scientists at the Cleveland Clinic Foundation, have shown that the protein, called cholesteryl ester transfer protein (CETP), is involved in the cellular storage and regulation of cholesterol and other fats and, as a result, probably has unexpected contributions to obesity and diabetes.

CETP is known to shuttle different types of fat between lipoproteins combinations of fat and protein that transport fats in the blood, Morton says. In this study, we show that CETP also shuttles fats inside fat cells between two separate areas and that fat cells with reduced levels of CETP are unable to process fats normally.

The new study, to be published in the July 27 issue of the Journal of Biological Chemistry, was selected as a Paper of the Week by the journals editors, meaning that it belongs to the top one percent of papers reviewed in significance and overall importance.

Research performed during the past decade has shown that CETP affects how a type of fat called cholesteryl ester is moved from the blood plasma into cells. Since fat cells make abundant CETP, Morton and Izem decided to examine what CETP does inside a fat cell and what would happen to fat cells that are deficient in CETP.

The scientists noticed that fat cells lacking CETP could not make and store cholesterol, cholesteryl ester, and another fat called triglyceride like normal fat cells do. In CETP-deficient cells, cholesteryl ester and triglyceride accumulated in a cellular compartment called the endoplasmic reticulum (ER), while an abnormally low amount of these fats was seen in lipid droplets local accumulations of fat in fat cells.

Morton and Izem suggest that, in normal cells, CETP transfers cholesteryl ester an
'"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
19-Jul-2007


Page: 1 2

Related biology news :

1. Penn researchers discover how key protein stops inflammation
2. UCF research links proteins, stem cells and potential Alzheimers treatment
3. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
4. Discovery of new protein could provide new understanding of male fertility
5. Unlocking proteins from their cellular shell
6. Altering a protein makes mice less fearful
7. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
8. MicroRNA works with Ago2 protein to regulate blood cell development
9. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
10. Call for EU to launch major project to map out all our proteins
11. MIT IDs link between brain tumor proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2019)... ... November 25, 2019 , ... Though the forecast for ... more than 55 million travelers expected to hit the roads and the skies. It’s ... it’s weight in truffle oil will offer a simple design, mouth-watering pictures of food, ...
(Date:11/27/2019)... MONTREAL (PRWEB) , ... November 27, 2019 , ... ... features a sleek hand-held device, equipped with surface electromyography (sEMG) sensors that measure ... ensure the activation of the specific muscles being targeted for treatment. Both patient ...
(Date:11/19/2019)... , ... November 19, 2019 , ... Project Lifeline ... Chain Drug Stores (NACDS) Foundation to address substance use disorder (SUD) – ... Two individuals who have led to the program’s effectiveness in preventing and treating opioid ...
Breaking Biology News(10 mins):
(Date:12/18/2019)... Fla. (PRWEB) , ... December 18, 2019 , ... Tune ... of Advancements, hosted by Ted Danson. Check local listings for more information on this ... innovations in augmented reality are helping to simplify complex system to increase the efficiency, ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... Inc. has received FDA 510(k) clearance for its latest CAPERE® Thrombectomy System ... data suggests the CAPERE® offers great benefits for first-in-line treatment for nonsurgical ...
(Date:12/4/2019)... ... 03, 2019 , ... Absolute Antibody Ltd. , an ... the Recombinant Antibody Network (RAN), a consortium of three expert centers at the ... common goal to generate recombinant antibodies at a proteome-wide scale. Under the new ...
(Date:12/4/2019)... ... December 03, 2019 , ... A new study released today ... reduce and even reverse fibrosis (scar tissue) buildup – also improves the range of ... of Medicine, was conducted on mice. , The tumor-destroying capabilities of radiation therapy ...
Breaking Biology Technology:
Cached News: