HOME >> BIOLOGY >> NEWS
New roles for growth factors: Enticing nerve cells to muscles

ne motor neuron whose cell body lies in the brain or spinal cord. Connections between muscle and nerve cells are established embryonically when newborn neurons extend axons to "wire" the appropriate muscle fiber.

The wiring process is highly orchestrated each motor neuron has already pledged allegiance to a particular muscle fiber before it reaches out to connect with its predetermined partner. But until now, scientists could only speculate how the invisible bond was formed.

"The question was how do these motor neurons know where to go," says Pfaff. "It would be a disaster if you wanted to move your arm and instead bent your back."

Earlier studies suggested that muscles lining the spine sent out chemical cues as a siren song for specific motor neurons known as MMCm cells. But when attempts to identify the enticing substance failed, many started to doubt its existence.

After screening numerous candidates, the Pfaff team found not only that FGF is expressed in target muscle, but that FGF "sensors," known as FGF receptors, are expressed in MMCm motor neurons. Furthermore, MMCm axons could not "hear" their muscle partner's call and failed to reach their destination in mouse mutants lacking the sensor molecule.

Finally, using mice engineered to express a fluorescent protein in MMCm neurons, the investigators demonstrated that only the glowing neurons extended axons in the direction of target cells expressing FGF.

"After a lot of hard work, we narrowed it down to FGFs and showed that they were indeed the long sought-after mysterious substance," says Pfaff. Neural stem cells can now be coaxed to develop into motor neurons in a test tube. In that artificial environment, explains Pfaff, "Most external cues that guide immature motor neurons during embryonic development will be missing." Hence the need to identify axon guidance factors. He continues, "It is not enough to make the right cell type, you need to connect the
'"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
15-Jun-2006


Page: 1 2 3

Related biology news :

1. ORNL researchers, supercomputer have large roles in DOE projects
2. Sunflower speciation highlights roles for transposable elements in evolution
3. Tumour development actors ERK1 and ERK2 found to play opposite roles
4. New research clarifies roles of calcium, vitamin D, and protein in bone health, fracture risk
5. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
6. Proteins take on new roles in malaria parasite
7. Illinois researchers to play key roles in study of emergence of life
8. Environment and genetic influences play different roles in boys and girls gender-role behavior
9. Flies on speed offer insight into the roles of dopamine in sleep and arousal
10. Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
11. Circadian clock controls plant growth hormone

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New roles for growth factors Enticing nerve cells muscles

(Date:7/24/2014)... gathered at NJIT this week for an all-day public ... Environmental Protection Agency (EPA) to dredge toxic sediment from ... The EPA has called the plan, which proposes removing ... sections of the riverbed, one of the largest cleanups ... dredged and disposed off-site. , "We need to ensure ...
(Date:7/24/2014)... To reduce fire hazard in the United States, wildland ... woody shrubs and suppressed trees (ladder fuels). These ... periods of low fire danger in order to dispose ... hazardous air pollutants, managers often cover all or part ... referred to as agricultural plastic, in order to keep ...
(Date:7/24/2014)... by the New Jersey Recovery Fund and conducted by ... and Public Policy at Rutgers University has found that ... the likelihood of community-based rebuilding solutions. Of the more ... were "pessimistic" or "very pessimistic" that the parts of ... better than they were before the storm; another 24 ...
Breaking Biology News(10 mins):Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2Study gives new perspective on agricultural plastic, debris burning, and air quality 2Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
(Date:7/25/2014)... WABC Radio show out of New York City, ... will be hosting California-based Vet-Stem, Inc.’s Founder and CEO, Robert ... pets. Dr. Harman first visited the show in November ... pets suffering from osteoarthritis and other degenerative diseases, as well ... , Young has invited Dr. Harman back to dial down ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 The Conferee ... for Topics for Conferee Networking. These two-hour sessions provide ... to meet and resolve problems, discuss new techniques, or ... deadline to submit a topic for consideration is August ... pittcon.org . The Conferee Networking committee will review the ...
(Date:7/25/2014)... California (PRWEB) July 25, 2014 Lawrence ... named to Thomson Reuters list of " The World's ... are part of the 3,000 researchers who were identified ... to recognize those who published the highest-impact work (2002-2012 ... research papers on combustion modeling . , "This ...
(Date:7/25/2014)... , July 25, 2014  Galmed Pharmaceuticals Ltd. ... company focused on the development and commercialization of a ... and cholesterol gallstones, today announced financial results for the ... 2014 Financial Summary: , Reported cash and cash ... with $137,000 at December 31, 2013.  , Reported ...
Breaking Biology Technology:Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6
Cached News: