New studies show topical glucosamine targets pigment overproduction

While the debate about glucosamine's efficacy in treating arthritis pain continues, a series of studies presented at the 64th American Academy of Dermatology (AAD) meeting indicates that a topical version of the supplement has effects on skin with the particular ability to normalize pigment overproduction in skin cells damaged by UV radiation exposure.

"While a great deal is known about glucosamine's safety profile and anti-inflammatory and anti-oxidant properties, there have been few well-controlled studies on how these properties could be used to improve skin health," says Alexa Kimball, M.D., assistant professor of dermatology, Harvard Medical School, who supervised one of the studies presented at the AAD. " It is really gratifying to see this level of research and validation on a topical cosmetic application. These findings could impact the way dermatologists treat UV related skin damage."

Data from three studies presented at the meeting focused on a formulation including N-acetyl glucosamine, a more stable version of glucosamine. N-acetyl glucosamine is a substance that inhibits glycosylation of pro-tyrosinase a key process in melanin overproduction in UV damaged skin cells. The in vivo and in vitro studies highlight improvements in hyperpigmentation, skin tone and barrier function. Data from the SIAscope, a non-invasive skin imaging system developed by Cambridge UK-based company Astron Clinica, enabled scientists to view the effects of the N-acetyl glucosamine complex on pigment producing cells giving scientists the ability for the first time ever to see the distribution of melanin across an entire human face.

NAG/Niacinamide Reduces Appearance of Hyperpigmentation in Vivo
Two double-blind placebo-controlled clinical studies examined the effects of N-acetyl glucosamine alone and a complex containing N-acetyl glucosamine plus niacinamide, a vitamin B derivative, which has previously been shown to be effective in redu

Contact: Shirley Johnson
Manning Selvage & Lee

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