"These data suggest that people with type 2 diabetes on a statin who switch from Avandia to ACTOS may realize incremental benefits to their lipid levels," said Robert Spanheimer, M.D., medical director for diabetes and metabolism at Takeda Pharmaceuticals North America. "Additionally, these results build on the growing body of evidence that ACTOS can confer benefits beyond blood glucose reduction: it can increase HDL and lower triglycerides. Low HDL cholesterol and elevated triglycerides represent cardiovascular risk factors for patients with type 2 diabetes."
Diabetic dyslipidemia, a risk factor for cardiovascular disease, is a profile of lipid abnormalities typically seen in people with type 2 diabetes. The pattern consists of elevated triglycerides, reduced levels of HDL cholesterol, normal or slightly-elevated levels of total and LDL cholesterol, and a shift toward smaller and denser LDL cholesterol particles. While dyslipidemia (irregularity of the lipid profile) also occurs in people who do not have diabetes, the specific abnormalities in the lipoprotein pattern characteristic of diabetic dyslipidemia appear to add excess risk for people with diabetes.
"What is unique about diabetic dyslipidemia is that lipid profiles may show normal levels of LDL, yet lower HDL and increased triglycerides that single lipid therapy alone may not address," noted Dr. Spanheimer.