HOME >> BIOLOGY >> NEWS
New study reveals signaling pathways required for expansion of pancreas stem cells

bone morphogenetic proteins (BMPs) targets in another cell type," says Sarvetnick. "We wanted to know whether BMP can cause an increase of Id expression, and if this would result in proliferation of the stem cells."

Her work incorporated several techniques to test these hypotheses, including the use of pancreas progenitor AR42J cells and transgenic mouse models. The team's data demonstrated that BMP4 signaling is necessary and sufficient for proliferation of AR42J progenitor cells, and that this growth is correlated with an increase in Id expression. The group also did immunohistochemistry staining to show that BMP and Id proteins are found in abundance in the embryonic mouse pancreas, which contains proliferating stem cells.

A possible source of pancreatic progenitor cells is thought to derive from pancreas epithelial duct cells. The pancreas of the mouse model that the Sarvetnick lab used contains an abundance of regenerating stem cells from the ducts. "Importantly, we found that if we inject an antibody that inhibits BMP4 into these mice, this significantly reduced the number of proliferating duct cells. We also found that in these mice inhibition of BMP4 results in an increase in the expression of a bHLH protein-dependent factor PAX6, which is required for the final differentiation of pancreatic islet cells."

The group's results indicate that BMP4 stimulation blocks the differentiation of endocrine progenitor cells through induction of Id, which, in its dual role, promotes their expansion, revealing a novel paradigm of signaling that explains the balance between expansion and differentiation of pancreatic epithelial progenitors.

"The complications of diabetes mellitus impose enormous medical, economic, and social costs to both the patient and the health-care system. These experiments provide novel insights into the signaling pathways that are required for expansion of pancreas stem cells," says Sarvetnick. "Our work may provide
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
16-May-2006


Page: 1 2 3

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. A study by the MUHC and McGill University opens a new door to understanding cancer
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Preclinical study links gene to brain aneurysm formation
7. In limiting life span, study finds booming bacteria innocent
8. Multicenter study nets new lung tumor-suppressor gene
9. MIT study: Maturity brings richer memories
10. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
11. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer

Post Your Comments:
(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... November 4, 2014   ... growth   Fuel3D , a developer of ... funding round totaling $6.4 million (£4 million). This funding builds ... earlier this year and paves the way for the commercial ... The funding round was led by Chimera Partners and ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
(Date:11/26/2014)... 2014 On January, 14, 2015, ... Washington D.C. science community to the UMBC campus for ... by the Protein Society, will take place from 9 ... 312. Through discussion, presentations and workshops, the free ... proteins, their role in the industry and the future ...
(Date:11/26/2014)... Whitehouse Laboratories is pleased to ... County (New Jersey) Chamber of Commerce as a ... organization in the North Jersey area, offers Whitehouse ... key clients in the pharmaceutical and biotechnology areas ... Membership enables Whitehouse Laboratories a higher level of ...
(Date:11/26/2014)... 2014 Continuing its award-winning streak, Nerium ... prestigious MarCom Awards for outstanding creative achievement by its ... MarCom Award, the organization’s top honor, in the Branding ... held in April of this year. The event showcased ... Additionally, Nerium was awarded a Gold MarCom Award in ...
(Date:11/26/2014)... West Chester, OH (PRWEB) November 25, 2014 ... International Holdings, has joined the Graphel Carbon Products team ... experience in sales, marketing, and customer service for the ... to add Miles to our team,” stated Dave Trinkley, ... Products. “His wide range of experience in the ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2
Cached News: