the proliferation of CD8+ T cells simply by increasing the biological activity of pre-existing IL-2 through the formation of antibody-cytokine immune complexes in vivo. We next combined recombinant IL-2 with IL-2 mAb, which led to an even more dramatic expansion. This expansion effect also extended to other types of antibody-cytokine complexes, such as IL-4/IL-4 mAb and IL-7/IL-7 mAb."
Despite these findings, Boyman noted, no one yet knows why these antibody-cytokine complexes are such potent immune response boosters in vivo.
"A few studies have suggested that injecting a cytokine together with the right antibody
increases the half-life of the cytokine in vivo, accompanied by a very mild immune activation," he said. "But our study suggests a different mechanism and that joining a cytokine to its specific antibody opens the way for selective and vigorous stimulation of T cell subsets. With some types of antibodies, injecting IL-2/IL-2 mAb complexes might be clinically useful for tumor immunotherapy and for expanding T cell numbers after bone marrow transplantation. On the other hand, expansion of CD4+ T regulatory cells by IL-2 combined with another type of IL-2 mAb might provide a basis for treating autoimmune disease."
Page: 1 2 Related biology news :1
Contact: Keith McKeown
Scripps Research Institute
. New study warns limited carbon market puts 20 percent of tropical forest at risk2
. Clones on task serve greater good, evolutionary study shows3
. Pollution causes 40 percent of deaths worldwide, study finds4
. A study by the MUHC and McGill University opens a new door to understanding cancer5
. New study suggests Concord grape juice may provide protection against breast cancer6
. Preclinical study links gene to brain aneurysm formation7
. In limiting life span, study finds booming bacteria innocent8
. Multicenter study nets new lung tumor-suppressor gene9
. MIT study: Maturity brings richer memories10
. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study11
. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer