HOME >> BIOLOGY >> NEWS
New target for HIV/AIDS drugs and vaccine discovered

Researchers from Rome, Italy, describe a finding in the August 2007 print issue of The FASEB Journal that could lead to new drugs to fight the HIV/AIDS virus, as well as new vaccines to prevent infection. It has been known that HIV proteins disable the antibody-forming part of the immune system (the homeland defense or acquired immune system). In this report, researchers demonstrate for the first time how the HIV-1 Nef viral protein delivers a one-two punch to the bodys innate immune system (our early warning system composed of dendritic and natural killer cells). First, Nef hijacks dendritic cells (DCs) to upset the function of natural killer (NK) cells. Second, after blocking this first line of defense against the immune system, Nef uses DCs and NK cells to create a microenvironment that actually makes it easier for HIV/AIDS to replicate.

According to Maria Giovanna Quaranta of Instituto Superiore de Sanit and first author of the article, The findings described in this work may have several implications for AIDS treatment: the understanding of Nef function, mechanism of action, and cellular partners might aid the discovery of suitable drugs able to block the activity of this smart protein. Quaranta added, An exciting possibility is the design of a vaccine including a mutated Nef protein unable to assist the virus in the control of its host.

The research findings also raise another intriguing possibility: Nef proteins may be able to boost or suppress DC and NK cell activity. If so, it may prove to be a valuable new therapeutic approach for people with diseases and disorders that involve overactive or underactive immune responses. DCs and NK cells play critical roles in the bodys initial defense against infection. DCs are instrumental in identifying foreign invaders to the body and then orchestrating an immune response that ultimately removes them. NK cells are among the first cells summoned by DCs to help isolate and contain the infection un
'"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
26-Jul-2007


Page: 1 2

Related biology news :

1. Huntingtons disease study shows animal models on target
2. When off-target is right on
3. Genomic analysis uncovers new targets for HIV vaccine
4. Bulls-eye -- Programs targeting math, science teacher shortage may get boost
5. Scientists take next step in understanding potential target for ovarian cancer treatment
6. On target
7. New way to target and kill antibiotic-resistant bacteria found
8. Weill Cornell team identifies potential new cancer drug target
9. CSHL scientists successfully target tumor microenvironment to stop cancer growth
10. Sleep deprivation affects airport baggage screeners ability to detect rare targets
11. Genomic signatures identify targeted therapies for lung cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft System ... over the next decade to reach approximately $14.21 billion by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... ... Vortex Biosciences , provider of circulating tumor cell (CTC) capture systems, ... Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. The peer ... Dr. Matthew Rettig at the University of California, Los Angeles. The publication describes the ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... machine manufacturers to re-engineer their control technology again and again. METTLER TOLEDO has ... for machine manufacturers. The videos illustrate how integration of the ACT350 into Siemens ...
(Date:5/21/2017)... , ... May 20, 2017 , ... ... helps avoid the lengthy trial and error process by finding the right antidepressant ... can also strengthen the doctor-patient relationship through a personalized approach to treatment. ...
(Date:5/18/2017)... ... May 16, 2017 , ... Clinical Supplies Management (“CSM”), a Great ... company continues to grow. CSM has doubled in size over the past six ... aggressive growth strategy. , Roger Gasper joins CSM as Chief Financial Officer. Roger ...
Breaking Biology Technology:
Cached News: