HOME >> BIOLOGY >> NEWS
New technique multiplies life span in simple organisms

A counterintuitive experiment has resulted in one of the longest recorded life-span extensions in any organism and opened a new door for anti-aging research in humans.

Scientists have known for several years that an extra copy of the SIR2 gene can promote longevity in yeast, worms and fruit flies.

That finding was covered widely and incorporated into anti-aging drug development programs at several biotechnology companies.

Now, molecular geneticists at the University of Southern California suggest that SIR2 instead promotes aging.

Their study, "Sir2 Blocks Extreme Life-Span Extension," appears in the Nov. 18 edition of the biology journal Cell. The lead author is Valter Longo, assistant professor in the Leonard Davis School of Gerontology and the USC College of Letters, Arts and Sciences.

Rather than adding copies of SIR2 to yeast, Longo's research group deleted the gene altogether.

The result was a dramatically extended life span - up to six times longer than normal - when the SIR2 deletion was combined with caloric restriction and/or a mutation in one or two genes, RAS2 and SCH9, that control the storage of nutrients and resistance to cell damage.

Human cells with reduced SIR2 activity also appear to confirm that SIR2 has a pro-aging effect, Longo said, although those results are not included in the Cell paper.

Since all mammals share key aging-related genes, the paper points to a new direction for human anti-aging research.

Longo proposes that SIR2 and possibly its counterpart in mammals, SIRT1, may block the organism from entering an extreme survival mode characterized by the absence of reproduction, improved DNA repair and increased protection against cell damage. Organisms usually enter this mode in response to starvation.

The long-lived organisms in Longo's experiment showed extraordinary resilience under stress.

"We hit them with o
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
17-Nov-2005


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2019)... ... ... In the wake of the success of IBBL’s international ... was launched in July 2018, in an agreement between IBBL, the International Society ... Association (BBCMBA). The one-year pilot programme offered two testing schemes: ‘DNA quantification and ...
(Date:3/29/2019)... ... March 29, 2019 , ... GenCure has selected G-CON Manufacturing, ... facility. The new facility, which will anchor the VelocityTX innovation center in San ... manufacturing capabilities to support clinical cell therapy trials. GenCure is a subsidiary of ...
(Date:3/26/2019)... ... March 26, 2019 , ... ... introduce the four recipients of the Society's 2019 Outstanding Achievement Award, Outstanding New ... will be presented at the ASGCT 22nd Annual Meeting . , Outstanding ...
Breaking Biology News(10 mins):
(Date:4/10/2019)... ... April 10, 2019 , ... ... locked into multiple agreements to help companies advance their innovations to clinical ... ranging from synthetic biology companies that are gene editing therapeutic cells for ...
(Date:4/9/2019)... ... , ... Sonny Bar Lisa, or Sonny for short, is a quarter horse ... a series of diagnostics, an MRI was performed which revealed Sonny had torn his ... found that VetStem Regenerative Cell Therapy may be a treatment option for ...
(Date:4/8/2019)... SAN FRANCISCO (PRWEB) , ... April 08, 2019 , ... ... to accredited investors a $15 million preferred equity investment in the privately held pharmaceutical ... dysfunction. Its leading drug, Lorexys, is targeted at female hypoactive sexual dysfunction disorder and ...
(Date:4/4/2019)... ... April 03, 2019 , ... LeadingBiotech, an exclusive ... dialogue, today announces its Boston CEO conference to be held May 28-29, 2019 ... and opportunities with high-level panels and discussions from past, present and future change-makers. ...
Breaking Biology Technology:
Cached News: