HOME >> BIOLOGY >> NEWS
New technique multiplies life span in simple organisms

A counterintuitive experiment has resulted in one of the longest recorded life-span extensions in any organism and opened a new door for anti-aging research in humans.

Scientists have known for several years that an extra copy of the SIR2 gene can promote longevity in yeast, worms and fruit flies.

That finding was covered widely and incorporated into anti-aging drug development programs at several biotechnology companies.

Now, molecular geneticists at the University of Southern California suggest that SIR2 instead promotes aging.

Their study, "Sir2 Blocks Extreme Life-Span Extension," appears in the Nov. 18 edition of the biology journal Cell. The lead author is Valter Longo, assistant professor in the Leonard Davis School of Gerontology and the USC College of Letters, Arts and Sciences.

Rather than adding copies of SIR2 to yeast, Longo's research group deleted the gene altogether.

The result was a dramatically extended life span - up to six times longer than normal - when the SIR2 deletion was combined with caloric restriction and/or a mutation in one or two genes, RAS2 and SCH9, that control the storage of nutrients and resistance to cell damage.

Human cells with reduced SIR2 activity also appear to confirm that SIR2 has a pro-aging effect, Longo said, although those results are not included in the Cell paper.

Since all mammals share key aging-related genes, the paper points to a new direction for human anti-aging research.

Longo proposes that SIR2 and possibly its counterpart in mammals, SIRT1, may block the organism from entering an extreme survival mode characterized by the absence of reproduction, improved DNA repair and increased protection against cell damage. Organisms usually enter this mode in response to starvation.

The long-lived organisms in Longo's experiment showed extraordinary resilience under stress.

"We hit them with o
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
17-Nov-2005


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 28, 2019 , ... ... and Clinical Research Organization), have recently passed their five-year milestone of collaboration ... and psychoneuroendocrine stress expertise, with a primary focus towards performing feasibility studies, ...
(Date:8/27/2019)... , ... August 27, 2019 , ... ... service, is pleased to announce that it has partnered with Bertec, a leading ... designs and manufactures Balance Advantage systems, a full line of clinical systems for ...
(Date:8/27/2019)... ... 27, 2019 , ... Advancements with Ted Danson will focus ... to broadcast 4Q/2019. Check local listings for more information. , This segment ... The show will highlight how Debiopharm is working to champion the synergy between ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... 2019 , ... Catalent, the leading global provider of advanced ... health products, today announced that Alex Haig, Senior Director, Engineering will present at ... Hall, Germany, on Sept. 18-19, 2019. , On Wednesday, Sept. 18 at 10:45 ...
(Date:9/8/2019)... (PRWEB) , ... September 05, 2019 , ... ... that Blaine Fitzgerald, former Vice President of Finance for Shopify, has been named ... Jones and healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has ...
(Date:8/29/2019)... , ... August 29, 2019 , ... ... disease affecting grapevines, a feat they hope will ultimately help protect the multibillion-dollar ... including several Rochester Institute of Technology faculty and alumni sequenced the microbiome found ...
(Date:8/27/2019)... , ... August 27, 2019 , ... Dr. Kim Carlson ... recently opened North Peninsula Veterinary Surgical Group , a new surgical practice in ... are plans to expand and add more veterinary specialists as the practice grows. , ...
Breaking Biology Technology:
Cached News: