HOME >> BIOLOGY >> NEWS
New technique multiplies life span in simple organisms

A counterintuitive experiment has resulted in one of the longest recorded life-span extensions in any organism and opened a new door for anti-aging research in humans.

Scientists have known for several years that an extra copy of the SIR2 gene can promote longevity in yeast, worms and fruit flies.

That finding was covered widely and incorporated into anti-aging drug development programs at several biotechnology companies.

Now, molecular geneticists at the University of Southern California suggest that SIR2 instead promotes aging.

Their study, "Sir2 Blocks Extreme Life-Span Extension," appears in the Nov. 18 edition of the biology journal Cell. The lead author is Valter Longo, assistant professor in the Leonard Davis School of Gerontology and the USC College of Letters, Arts and Sciences.

Rather than adding copies of SIR2 to yeast, Longo's research group deleted the gene altogether.

The result was a dramatically extended life span - up to six times longer than normal - when the SIR2 deletion was combined with caloric restriction and/or a mutation in one or two genes, RAS2 and SCH9, that control the storage of nutrients and resistance to cell damage.

Human cells with reduced SIR2 activity also appear to confirm that SIR2 has a pro-aging effect, Longo said, although those results are not included in the Cell paper.

Since all mammals share key aging-related genes, the paper points to a new direction for human anti-aging research.

Longo proposes that SIR2 and possibly its counterpart in mammals, SIRT1, may block the organism from entering an extreme survival mode characterized by the absence of reproduction, improved DNA repair and increased protection against cell damage. Organisms usually enter this mode in response to starvation.

The long-lived organisms in Longo's experiment showed extraordinary resilience under stress.

"We hit them with o
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
17-Nov-2005


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly growing customer ... the Geneious Biologics platform as a premium hub for bioinformatics and computer programming ... “The Geneious team has done an excellent job accommodating our specific data, resulting ...
(Date:6/6/2019)... ... June 05, 2019 , ... Pelican BioThermal , ... station and service center in Mexico City, Mexico. Mexico is the second largest ... more than $1.75 billion in pharmaceutical exports since 2015. The Mexico City network ...
(Date:6/4/2019)... ... 04, 2019 , ... Molecular Devices, a global leader in ... new President of Molecular Devices, replacing Greg Milosevich who has been appointed President ... Since joining Molecular Devices in a scientific engineering role, Ms. Murphy has held ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 29, 2019 , ... ... applications from the USPTO providing proprietary interest to our methodology, processes, and ... DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep ...
(Date:5/21/2019)... ... May 21, 2019 , ... DuPont Nutrition & ... the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, strengthening relationships and ... which is supported through a partnership with “Ethiopia Invest”, will run through May ...
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side ... drill team and barrel racing, among other activities. When loping around a corner in ... from being a busy horse to only being able to walk. Fortunately Atlas’ owner, ...
(Date:5/2/2019)... ... 2019 , ... The centuries old practice of brewing beer thrives today across ... and even home brewing clubs scattered across the nation. , But proper beer ... can produce a superb product. Students at South Dakota School of Mines & ...
Breaking Biology Technology:
Cached News: