HOME >> BIOLOGY >> NEWS
New technique provides insights into gene regulation

Researchers at the University of Toronto have developed a new technique that enables them to examine the genetic material of cells in greater detail than ever before, a finding that could lead to better ways to study and diagnose diseases.

The U of T research is published in the Dec. 22 issue of Molecular Cell. The new technique developed by the investigators uses a modified type of "gene chip" and a computer program to accurately monitor alternative splicing, a cellular process through which basic genetic material becomes more complex and acquires the ability to control genetic messages (mRNAs) that are required for the development of complex organisms.

"Now that we can look at mRNA in more detail, it has opened the door to understanding more about some diseases," explains lead investigator Professor Benjamin Blencowe of U of T's Banting and Best Department of Medical Research (BBDMR) and the Department of Medical Genetics and Microbiology, who notes out-of-control RNA splicing is involved in many human diseases, including cancers and birth defects. "The new information we can now obtain could also provide insights into new treatments."

Each cell in the human body contains about 25,000 genes. Although human tissues and organs all have the same genes, some of the genes are "turned on" and others "off". The complete set of genes in humans is only several times that of budding yeast and close to the number found in the significantly less complex nematode worm, C.elegans, a microscopic ringworm.

How very different organisms develop from comparable numbers and types of genes has been a major question since the genetic similarity was discovered. Scientists are trying to understand what turns a gene "off" or "on", or alters its activity when "on" in other words, the process of gene regulation.

The answer may lie in the coding segments (exons) of human genes, which are separated by long, non-coding segments (introns). The exo
'"/>

Contact: Christina Marshall
c.marshall@utoronto.ca
416-978-5948
University of Toronto
21-Dec-2004


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
(Date:3/16/2017)... - Against identity fraud with DERMALOG solutions "Made in Germany "  ... ... multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial contribution against identity ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... ... A recent survey conducted by the Weed Science Society of America (WSSA) ... categories of broadleaf crops, fruits and vegetables, while common lambsquarters ranks as the weed ... in the 2016 survey, the second conducted by WSSA. A 2015 baseline survey ...
(Date:5/23/2017)... ... May 22, 2017 , ... A ... in San Diego, California, this August will feature high-level speakers on quantum devices, ... , SPIE Optics and Photonics, the largest multidisciplinary optical sciences meeting in North ...
(Date:5/23/2017)... ... 23, 2017 , ... Bacterial biofilms, surface adherent communities of bacteria that are ... from food poisoning and catheter infections to gum disease and the rejection of medical ... of dollars per year, there is currently a paucity of means for preventing their ...
(Date:5/22/2017)... ... May 22, 2017 , ... ... other leaders of the Maryland Biohealth community in developing and issuing recommendations to ... 3 U.S. BioHealth Innovation Hub by 2023. , The recommendations ...
Breaking Biology Technology:
Cached News: