HOME >> BIOLOGY >> NEWS
New technique provides insights into gene regulation

Researchers at the University of Toronto have developed a new technique that enables them to examine the genetic material of cells in greater detail than ever before, a finding that could lead to better ways to study and diagnose diseases.

The U of T research is published in the Dec. 22 issue of Molecular Cell. The new technique developed by the investigators uses a modified type of "gene chip" and a computer program to accurately monitor alternative splicing, a cellular process through which basic genetic material becomes more complex and acquires the ability to control genetic messages (mRNAs) that are required for the development of complex organisms.

"Now that we can look at mRNA in more detail, it has opened the door to understanding more about some diseases," explains lead investigator Professor Benjamin Blencowe of U of T's Banting and Best Department of Medical Research (BBDMR) and the Department of Medical Genetics and Microbiology, who notes out-of-control RNA splicing is involved in many human diseases, including cancers and birth defects. "The new information we can now obtain could also provide insights into new treatments."

Each cell in the human body contains about 25,000 genes. Although human tissues and organs all have the same genes, some of the genes are "turned on" and others "off". The complete set of genes in humans is only several times that of budding yeast and close to the number found in the significantly less complex nematode worm, C.elegans, a microscopic ringworm.

How very different organisms develop from comparable numbers and types of genes has been a major question since the genetic similarity was discovered. Scientists are trying to understand what turns a gene "off" or "on", or alters its activity when "on" in other words, the process of gene regulation.

The answer may lie in the coding segments (exons) of human genes, which are separated by long, non-coding segments (introns). The exo
'"/>

Contact: Christina Marshall
c.marshall@utoronto.ca
416-978-5948
University of Toronto
21-Dec-2004


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New technique provides insights into gene regulation

(Date:8/28/2014)... Society of America (ESA) is pleased to announce the ... of the Society. Honorary Membership acknowledges those who have ... involvement in the affairs of the Society that has ... selected by the ESA Governing Board and then voted ... honored at the Awards Ceremony at Entomology 2014, ESA,s ...
(Date:8/28/2014)... is available in German . ... owes its name to a striking pattern of blue stripes ... cells, reflective silvery cells, and yellow cells emerge during growth ... as a multilayered mosaic to compose the characteristic colour pattern. ... types have to interact to form proper stripes, the embryonic ...
(Date:8/28/2014)... A Mayo Clinic researcher and his collaborators have ... and enhance the process of re-engineering cells for biomedical ... network biology methods to aid stem cell engineering. Details ... are described in two back-to-back papers in the journal ... broad range of uses for all types of cell-based ...
Breaking Biology News(10 mins):Fred Baxendale selected as Honorary Member of the Entomological Society of America 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3New tool aids stem cell engineering for medical research 2
(Date:8/29/2014)... SAN DIEGO, Aug. 29, 2014  Pfenex Inc. ... in the development of high-value and difficult to ... business update and reported financial results for the ... "With the successful completion of our initial public ... advance our biosimilar product candidates, derived from our ...
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 The ... $5.6 billion in 2019. It is expected to ... to 2019, and was valued at $1.8 billion ... by Transparency Market Research. , For more information ... http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, titled “Companion ...
(Date:8/29/2014)... 29, 2014 According to a new market ... global orthobiologics market was valued at USD 3,754.6 million in ... 5,519.9million in 2019at a CAGR of 5.9% from 2013 to ... and above is afflicted by bone and joint disorders, and ... 2020. This has and will continue to increase the demand ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
Cached News: