HOME >> BIOLOGY >> NEWS
New test may identify cardiovascular disease earlier

DURHAM, N.C. -- By analyzing the "trash" left in blood by the body's metabolism, a team of cardiologists and geneticists at Duke University Medical Center has found what may be new markers for measuring cardiovascular health, to complement such traditional measures as cholesterol and triglycerides.

The markers also may prove useful as "early warning systems" for coronary artery disease, alerting physicians to patients who need preventive treatment to keep their disease from progressing to danger levels, according to the researchers.

The analysis is one of the first to use metabolomics -- that is, the systematic study of the unique chemical fingerprints that specific cellular processes leave behind -- to better understand the underlying biological pathways involved in families with coronary artery disease, the researchers said. They likened metabolomics to analyzing the contents of a trash can in order to learn about the people who filled the can.

The team measured minute amounts of metabolites, or byproducts of cellular metabolism, in the blood of people whose extended family members had a history of developing coronary artery disease at an early age. Using the measurements, the researchers generated "metabolite profiles" of each individual.

Based on these profiles, the researchers demonstrated that many of the metabolites have stronger heritabilities, a measure of genetic predisposition, than do conventional markers such as cholesterol. This finding suggests that it may be possible to identify people at an early age who would be most likely to develop coronary artery disease, the researchers said.

"The results of our studies may have significant clinical implications above and beyond the ability of identifying the genes that underlie the susceptibility to coronary artery disease," said cardiologist and study team leader Svati Shah, M.D., who reported the findings on Tuesday, Nov. 14, at the annual scientific sess
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
14-Nov-2006


Page: 1 2 3

Related biology news :

1. Research aims to identify markers for menopausal women at risk for deadly blood clot
2. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
3. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
4. U-M researchers identify gene involved in breast cancer
5. Scientists identify 2 distinct Parkinsons networks
6. NIEHS researchers identify enzyme critical in DNA replication
7. Researchers identify genetic mutation that may alter tumor cell proliferation
8. Researchers discover method for identifying how cancer evades the immune system
9. Scientists identify first gene linked to scoliosis
10. LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
11. Researchers identify fifth gene responsible for Joubert syndrome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New test may identify cardiovascular disease earlier

(Date:6/18/2013)... Department,s National Renewable Energy Laboratory (NREL), and the ... describing a novel cellulose-degrading enzyme from a marine ... as the gribble. , Gribbles are biologically ... to produce their own enzymes instead of using ... eat. New biomass-degrading enzymes from novel sources such ...
(Date:6/18/2013)... The National Institutes of Health has awarded $12.7 ... a selection of pharmaceutical industry compounds to explore ... including Alzheimer,s disease, Duchenne muscular dystrophy and schizophrenia. ... Uses for Existing Molecules, is led by the ... funded by the NIH Common Fund. , The ...
(Date:6/18/2013)... chemical modification of DNA and this modification can ... sequence. Until now, scientists believed that this epigenetic ... Today, a team of researchers from the University ... Louis-Jeantet Professor at the Faculty of Medicine, reveals ... that DNA methylation may play both a passive ...
Breaking Biology News(10 mins):Novel enzyme from tiny gribble could prove a boon for biofuels research 2NIH to fund collaborations with industry to identify new uses for existing compounds 2NIH to fund collaborations with industry to identify new uses for existing compounds 3NIH to fund collaborations with industry to identify new uses for existing compounds 4The secret of DNA methylation 2
(Date:6/18/2013)... Los Angeles, CA (PRWEB) June 18, 2013 (PRWEB) ... of construction’s #1 time and attendance system in ... transfer software that shares employee data and payroll ... , AccountLinx Plus automates ExakTime software ... applications. The software imports employee data from a ...
(Date:6/18/2013)... 2013 Nasseo, Inc. today announces that ... out of hundreds of applicants by the Arizona ... Innovation Challenge . The Arizona Innovation Challenge (AIC) awards ... commercialization challenge, granting a financial award to what it ... Nasseo’s state of the art dental and orthopedic implant ...
(Date:6/18/2013)... 2013  AMRI (NASDAQ: AMRI ) ... , site has received approval to expand ... to handle Schedule 2 and 2N controlled substances. ... Burlington,s physical security and quality ... (Logo: http://photos.prnewswire.com/prnh/20120229/NY61160LOGO ) With ...
(Date:6/18/2013)... June 18, 2013 ... announced the addition of the report " ... " to their offering.      ... reviews basics of human genome variations, development ... large and small sequencers are described as ...
Breaking Biology Technology:ExakTime Introduces AccountLinx Plus 2Nasseo Named 2013 Innovation Challenge Winner by Arizona Commerce Authority 2AMRI Burlington Receives DEA Approval to Handle Controlled Substances 2DNA Sequencing: Technologies, Markets and Companies - 2013 Report 2
Cached News: