HOME >> BIOLOGY >> NEWS
New treatment model for HIV

Treatment of HIV patients must balance the need to suppress viral replication against the harmful side effects and significant cost to the patient of antiretroviral therapy. This tradeoff has led to the development of various drug-sparing HIV-1 treatment strategies, which often results in the emergence of resistant viruses and overall treatment failure. This has prompted an interest in induction–maintenance (IM) treatment strategies, in which brief intensive therapy is used to reduce host viral levels, which is then followed by a simplified and more easily tolerated maintenance regimen.

IM approaches remain an unproven concept in HIV therapy. In a study publishing July 13, 2007 in PLoS Computational Biology, clinical responses to antiretroviral drug therapy are simulated for the first time, and the model is then applied to IM therapy. Marcel Curlin, Shyamala Iyer, and John Mittler, from the University of Washington, find that IM is expected to be successful beyond three years and that six to ten months of induction therapy should achieve durable suppression of HIV and maximize the possibility of eradicating viruses resistant to the maintenance regime. They also find the counter-intuitive result that for induction regimens of limited duration the optimal time to initiate induction therapy may be several days or weeks after the start of regular (maintenance) therapy.

These results are important not simply because they show how this particular, albeit important, therapy strategy may be optimized, but because they illustrate the more general potential for mathematical models to influence therapy decisions. “Our experience has been that clinicians and policy makers are often hesitant to consider, sometimes even hostile towards, mathematical modeling approaches. Instead, they rely on intuition or await the results of expensive, long-term clinical trials”, says Mittler. By presenting a detailed model that makes concrete quantitative predictions and
'"/>

Contact: Johanna Dehlinger
press@plos.org
415-624-1202
Public Library of Science
12-Jul-2007


Page: 1 2

Related biology news :

1. New system of wastewater treatment could reduce the size of treatment plants by half
2. UCF research links proteins, stem cells and potential Alzheimers treatment
3. Geisinger scientist seeks cure for Lou Gehrigs disease, creating device to find treatment
4. System to analyze beating heart stem cells could lead to heart attack treatments
5. Gene expression pattern could lead to improved treatment of pediatric septic shock
6. Molecular detectors may refine cancer treatment
7. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
8. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. New research shows vaginal bacteria vary among healthy women, need customized treatment
11. University of Cincinnati receives $1.7M to research molecular treatment of brain injury

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... (PRWEB) , ... August 25, ... ... clinical-stage biotechnology company developing novel pharmaceuticals targeting mitochondria, in partnership with Essex ... enrolment in its pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ophthalmic ...
(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. ... the X-ray analysis community, presenting current news and crystallographic research. , The ...
(Date:8/21/2020)... ... August 19, 2020 , ... The 19th Annual ... science, data science, informatics and IT leaders goes VIRTUAL and announces its updated ... and change, Bio-IT takes the leadership role of keeping our life science community ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory Gating ... countries, has reached its 20th anniversary of worldwide use. Introduced in the US ... universities including University of Pennsylvania, University of Michigan, University of Maryland, University of ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt ... the market and we were pleased that the IFT jury recognized that.” reFRESH™ couples ... a natural way to extend the shelf life and improve the safety of perishable ...
(Date:7/10/2020)... , ... July 09, 2020 ... ... company, announced today that Massachusetts Institute of Technology (MIT) has expanded the ... license allows PathSensors to move into the point-of-care diagnostic market, focusing initially ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has ... Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and ... elite awards program, highlighting outstanding examples of how technology innovations and strategic initiatives ...
Breaking Biology Technology:
Cached News: