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New treatment options for patients with prostate cancer

Paris, France, Monday 31 October 2005 - New findings on different treatment options including new therapies for prostate cancer were presented at the 13th European Cancer Conference (ECCO).

A Dutch study suggested treating prostate cancer patients with higher doses of radiotherapy significantly improved patient outcome and treatment over a five-year period. Another evaluated which patients would benefit from early adjuvant anti-androgen therapy. Data was presented on a new compound to treat androgen independent prostate cancer. An Australasian study reviewed the benefits of administering maximal androgen deprivation treatment before radiotherapy.

The Dutch study, a multicentre randomised Phase III trial, recruited 669 patients with stage T1b-T4N0M0 (free from cancer in the lymph nodes and no metastasis has occurred) prostate cancer and with baseline characteristics of median PSA (prostate specific antigen) of 13.0ng/ml. 63% of patients had T1-2 tumours (smaller tumours localised to the prostate). Patients were divided into three prognostic groups of low, intermediate and high risk which included 18%, 27% and 55% of patients respectively. These groups were treated with either the higher dose of radiotherapy at 78Gy or the conventional dose at 68Gy. Some of the patients from the intermediate and high risk groups were also receiving hormonal therapy (143 in total).

The aim of the study was to determine whether the higher dose of radiotherapy, 78Gy, offered more effective treatment of prostate cancer than the conventional dose at 68Gy. The study's endpoint was defined as 'freedom from failure' or clinical failure (clinical relapse or start of hormone treatment).

Results indicated at five years, that 'freedom from failure' was significantly improved in patients receiving the 78Gy radiotherapy dose than those receiving the 68Gy dose. The intermediate risk patients experienced the most benefit from the higher dose treatment (74% vs 58%. p=0
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Contact: Kirsten Mason
kirsten.mason@toniclc.com
44-077-969-55353
Federation of European Cancer Societies
2-Nov-2005


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