HOME >> BIOLOGY >> NEWS
New type of optical microscopy attains near-molecular resolution

CAMBRIDGE, Mass., Aug. 11, 2006 -- A new type of microscopy invented by Xiaowei Zhuang and colleagues at Harvard University and the Howard Hughes Medical Institute delivers spatial resolution more than 10 times better than that of conventional optical microscopes, putting scientists tantalizingly close to the first crisp, ultra-resolution, real-time imaging of living biomolecules and cells.

The new technique can currently resolve objects as small as 20 nanometers, or 20 billionths of a meter, a resolution Zhuang says could be pushed, with further improvements, to molecular scale.

Zhuang, along with Michael J. Rust and Mark Bates at Harvard, describes stochastic optical reconstruction microscopy, or STORM, in the Aug. 9 online edition of the journal Nature Methods.

"We believe this technique has the potential to transform molecular and cellular imaging in biology," says Zhuang, an HHMI investigator and professor of chemistry and chemical biology in Harvard's Faculty of Arts and Sciences. "High-resolution bio-imaging is now accomplished using electron microscopy, which requires a 'dead' sample. The scientific community has long hoped for a technique offering STORM's attributes: touchless, gentle, real-time imaging of live biological samples at the molecular scale."

At the heart of STORM's success are fluorophores, glowing molecules that can be driven between a fluorescent and a dark state hundreds of times with repeated exposure to light with different colors. Zhuang, Bates, and colleague Tim Blosser discovered such a fluorophore and described it in Physical Review Letters in 2005.

"Scientists have long known that individual fluorophores can be localized to nanometer accuracy," Zhuang said. "However, light from fluorophores that are close to each other cannot easily be separated, making it very difficult to resolve these objects. After we discovered this wonderful switchable fluorophore, we realized that it offers o
'"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-275-3628
Harvard University
11-Aug-2006


Page: 1 2

Related biology news :

1. Snakes virtual glasses, leopard spots and all-optical transistors
2. UKs first optical network gives boost to e-Science
3. Magnetic resonance microscopy research lands professor NSF award
4. Researchers use multiphoton microscopy to watch chromosomes in action
5. New law for resolution allows unprecedented sharpness in fluorescence microscopy
6. Real time microscopy tracks the course of developing T cells
7. MicroRNA conflict resolution
8. New Years resolution No. 1: Prevent cancer, use olive oil.
9. With record resolution and sensitivity, tool images how life organizes in a cell membrane
10. Recombination protein dynamics observed with single monomer resolution
11. Atomic-resolution structure of a ribozyme yields insights into RNA catalysis and the origins of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2019)... ... February 20, 2019 , ... RoosterBio, Inc, ... expand the company’s footprint in Frederick, MD after a year of rapid growth. ... human mesenchymal stem/stromal cell (hMSCs) products to streamline their product development efforts in ...
(Date:2/22/2019)... , ... February 21, 2019 , ... ... (Fuzionaire Dx) have executed a research agreement establishing a collaborative program to work ... will be to develop new radiopharmaceutical lead candidates and will explore Fuzionaire Dx’s ...
(Date:2/14/2019)... ... February 14, 2019 , ... This year’s conference in ... 80 scientific sessions and 2,100 presentations. Given SOT’s mission to bring together researchers ... OpenLiver™ 3D cell culture model initiative that it recently launched with Biopredic ...
Breaking Biology News(10 mins):
(Date:3/4/2019)... (PRWEB) , ... March 04, 2019 , ... Stay on top of current hot topics ... Access to all webinars is free, so be sure to register today to save your ... to see our upcoming webinars: , CLINICAL TRIALS, , March ...
(Date:2/27/2019)... ... February 26, 2019 , ... Superior Controls, Inc., a ... with 140 employees on both the east and west coasts, today announced that ... of New Hampshire. Sandmaier, a senior project engineer, joins Taggart McCormick, P.E., Anthony ...
(Date:2/22/2019)... MURRIETA, Calif. (PRWEB) , ... February 20, 2019 ... ... incubator and SeqOnce , an emerging leader in the rapidly growing NGS ... sample solutions for the Murrieta Genomics laboratory and incubator. , "As an innovation ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... to Novel Captcha Systems. , The patents in lot 92 ... and tests are used to distinguish between human users and computers through exploiting ...
Breaking Biology Technology:
Cached News: