HOME >> BIOLOGY >> NEWS
New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds

COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found.

"The results of the study have potential implications for how we classify the commonly used anti-inflammatory and pain drugs for aches, pains, and fever," says Colin Funk, a professor of Biochemistry and Physiology at Queen's and Canada Research Chair in Molecular, Cellular and Physiologiocal Medicine.

Published on-line in Nature Medicine, the study was conducted in collaboration with University of Pennsylvania researchers.

The study was initiated to explore the biochemistry associated with COX-2 inhibitors such as Vioxx, Bextra and Celebrex, which are now associated with an increased incidence of heart attack and stroke. Researchers looked at mice that were genetically modified so that their COX-2 was inhibited to create a physiology in mice that roughly mimics that of users of COX-2 inhibitors. They found that the COX-1 enzymes in the mice "hooked up" in an unanticipated way with their remaining COX-2 enzymes creating what is called a new heterodimer.

Dr. Funk's co-researcher, Queen's biochemist Robert Campbell, has developed a computer model to show how the COX-1/COX-2 molecules can associate.

"It's possible the COX-2 inhibitor medications may affect the resulting new enzyme which is a mix of COX-1 and COX-2," says Dr. Funk.

This effect is being further explored by scientists and may lead to a broadened understanding of the biochemistry of common pain medications. It is now pointing toward possible alternatives to drugs like Vioxx and Celebrex, says Dr. Funk.

A study published April 13 by The Journal of Clinical Investigation (JCI) by the same research team found that new types of anti-inflammatory drugs may reduce COX-2 cardiovascular problems. That study was conducted after this one and incorporated the genetically modified mice c
'"/>

Contact: Sarah Withrow
withrows@post.queensu.ca
613-533-3280
Queen's University
29-May-2006


Page: 1 2

Related biology news :

1. Multinational research: protecting ecology means understanding people, too
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Discovery of new protein could provide new understanding of male fertility
4. Forsyth scientists gain new understanding of adult stem cell regulation
5. New role for protein in fat cells may improve understanding of obesity and diabetes
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists take next step in understanding potential target for ovarian cancer treatment
8. Major breakthrough in understanding how HIV interferes with infected cell division
9. Arctic Observing Network as a tool for understanding Arctic change
10. UCF professor finds bacterial pathogen may be key to understanding cancer development
11. Crucial progress in understanding Fragile X mental retardation protein

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2019)... (PRWEB) , ... December 01, 2019 , ... ... latest and greatest tools, technologies, and techniques to hit the life-science landscape. For ... of innovative products speeding work in laboratories and facilitating biological discovery. This year’s ...
(Date:11/22/2019)... ... November 21, 2019 , ... ... Park Comprehensive Cancer Center have announced a major step forward with that therapy, ... have announced that the company, spun off from Roswell Park in 2012, has ...
(Date:11/19/2019)... (PRWEB) , ... November 19, 2019 , ... Hosted at ... MJBizDaily , MJBizCon 2019 is the largest gathering of MJBiz business professionals ... 35,000, and programming to benefit every sector, there is no show quite like it. ...
Breaking Biology News(10 mins):
(Date:12/23/2019)... (PRWEB) , ... December 23, 2019 , ... ... leak detection systems for the Pharmaceutical, Biotechnology and Medical Device Industries, is excited ... at the Parenteral Drug Association (PDA) Container Closure Integrity Testing Basic Training ...
(Date:12/18/2019)... ... December 18, 2019 , ... Tune in to CNBC on Saturday, December 28th ... local listings for more information on this program. , With a look at ... simplify complex system to increase the efficiency, safety and effectiveness of equipment, systems, and ...
(Date:12/4/2019)... (PRWEB) , ... December 03, 2019 , ... A new ... Syneos Health, Teleflex, and CONMED as the overall best medical sales companies to work ... Medical Sales survey polled over 1,200 professionals from the MedReps community to identify ...
(Date:12/4/2019)... N.C. (PRWEB) , ... December 03, 2019 , ... A ... studies have shown can reduce and even reverse fibrosis (scar tissue) buildup – also ... at Stanford University School of Medicine, was conducted on mice. , The tumor-destroying ...
Breaking Biology Technology:
Cached News: