HOME >> BIOLOGY >> NEWS
New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds

COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found.

"The results of the study have potential implications for how we classify the commonly used anti-inflammatory and pain drugs for aches, pains, and fever," says Colin Funk, a professor of Biochemistry and Physiology at Queen's and Canada Research Chair in Molecular, Cellular and Physiologiocal Medicine.

Published on-line in Nature Medicine, the study was conducted in collaboration with University of Pennsylvania researchers.

The study was initiated to explore the biochemistry associated with COX-2 inhibitors such as Vioxx, Bextra and Celebrex, which are now associated with an increased incidence of heart attack and stroke. Researchers looked at mice that were genetically modified so that their COX-2 was inhibited to create a physiology in mice that roughly mimics that of users of COX-2 inhibitors. They found that the COX-1 enzymes in the mice "hooked up" in an unanticipated way with their remaining COX-2 enzymes creating what is called a new heterodimer.

Dr. Funk's co-researcher, Queen's biochemist Robert Campbell, has developed a computer model to show how the COX-1/COX-2 molecules can associate.

"It's possible the COX-2 inhibitor medications may affect the resulting new enzyme which is a mix of COX-1 and COX-2," says Dr. Funk.

This effect is being further explored by scientists and may lead to a broadened understanding of the biochemistry of common pain medications. It is now pointing toward possible alternatives to drugs like Vioxx and Celebrex, says Dr. Funk.

A study published April 13 by The Journal of Clinical Investigation (JCI) by the same research team found that new types of anti-inflammatory drugs may reduce COX-2 cardiovascular problems. That study was conducted after this one and incorporated the genetically modified mice c
'"/>

Contact: Sarah Withrow
withrows@post.queensu.ca
613-533-3280
Queen's University
29-May-2006


Page: 1 2

Related biology news :

1. Multinational research: protecting ecology means understanding people, too
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Discovery of new protein could provide new understanding of male fertility
4. Forsyth scientists gain new understanding of adult stem cell regulation
5. New role for protein in fat cells may improve understanding of obesity and diabetes
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists take next step in understanding potential target for ovarian cancer treatment
8. Major breakthrough in understanding how HIV interferes with infected cell division
9. Arctic Observing Network as a tool for understanding Arctic change
10. UCF professor finds bacterial pathogen may be key to understanding cancer development
11. Crucial progress in understanding Fragile X mental retardation protein

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... ... outstanding recognition and multiple awards for not only the products and treatments developed, ... Skincare and Vivace® Microneedle RF. All the brands built by ABM have received ...
(Date:7/1/2020)... ... July 01, 2020 , ... ... and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced today the ... PhD. Senior Fellows are charged with supporting the organization’s initiatives and overall vision. ...
(Date:6/23/2020)... ... June 23, 2020 , ... Kemp ... announced that the company has received ISO9001:2015 certification for the development and ... industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to a ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone Partners ... has announced the placement of Julianne Averill , CPA, as Chief Financial ... financial operations and implementing key business strategies to accelerate Alveo’s growth as the ...
(Date:8/12/2020)... , ... August 11, 2020 ... ... biopharmaceutical cold chain validation engineering firm, is making available for free its ... need to incorporate concurrent transport simulation testing into today’s biologics licensing application ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
Breaking Biology Technology:
Cached News: