HOME >> BIOLOGY >> NEWS
New understanding of parasite cell structures may provide treatments for serious tropical diseases

Don't even think about trying to pronounce it. Although it is found in many organisms including humans, glycosylphosphatidylinositol has remained a mouthful for laymen and a puzzle for scientists. And yet GPIs, as science thankfully calls these cellular lipids, are important in numerous biological functions, including disease transmission.

Now, for the first time, cellular biologists at the University of Georgia have developed new tools to study and localize GPIs in living organisms and are discovering a new understanding of how they work in tropical parasites that cause human disease and suffering.

The research was published in the May 9 issue of The FEBS (Federation of European Biochemical Societies) Journal by Kojo Mensa-Wilmot, professor of cellular and molecular biology, and Sandesh Subramanya, a former doctoral student in the department of cellular biology at UGA.

While some GPIs are "attached" to proteins cells, other GPIs are "free," and it is these footloose cellular wanderers that interested Mensa-Wilmot. Until the UGA team developed new molecular tools to study free GPIs in living organisms, their function was unclear at best. Now, new avenues of study could open because of these molecular tools.

Although the term "lipid" is often substituted for "fat," these cell components actually have numerous functions. They are hydrocarbon-containing organic compounds that living cells must have to maintain structure and function. Glycolipids are attached to carbohydrates, and they are involved with cellular energy and also serve as markers for cellular recognition.

The researchers discovered a new function for these glycolipids--they are cleaved in response to cell stress caused by changes in osmotic pressure and relative acidity or alkalinity.

The research by the UGA team is especially important in better understanding the parasite Trypanosoma brucei, which causes human African trypanosomiasis, a disease that affects
'"/>

Contact: Kim Carlyle
kcarlyle@uga.edu
706-583-0913
University of Georgia
9-May-2006


Page: 1 2 3

Related biology news :

1. Multinational research: protecting ecology means understanding people, too
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Discovery of new protein could provide new understanding of male fertility
4. Forsyth scientists gain new understanding of adult stem cell regulation
5. New role for protein in fat cells may improve understanding of obesity and diabetes
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists take next step in understanding potential target for ovarian cancer treatment
8. Major breakthrough in understanding how HIV interferes with infected cell division
9. Arctic Observing Network as a tool for understanding Arctic change
10. UCF professor finds bacterial pathogen may be key to understanding cancer development
11. Crucial progress in understanding Fragile X mental retardation protein

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/6/2019)... Va. (PRWEB) , ... November 06, 2019 , ... ... today that Donald Stanski, MD, a senior pharmaceutical industry executive with expertise in ... and simulation for drug and disease strategic data analytics, has joined the firm ...
(Date:11/5/2019)... ... November 05, 2019 , ... Dr. Lauren Kopp celebrates ... to Seattle, WA, including porcelain veneers , smile makeovers, dental implants, and ... of Washington, Dr. Kopp is passionate about serving her Seattle community with empathy ...
(Date:10/30/2019)... Va. (PRWEB) , ... October 30, 2019 , ... ... offering from the Farm Credit Knowledge Center in which participants will learn about ... industry best practice relating to these technologies. , Participants will have the ...
Breaking Biology News(10 mins):
(Date:11/2/2019)... ... October 31, 2019 , ... A clinical ... with each other: study managers, principal investigators, supply chain managers, manufacturers, IRT, CRAs ... not informed of the latest data, potentially leading to patient risk. , By ...
(Date:10/29/2019)... ... 2019 , ... CaroGen Corporation , a biotechnology company, today announced three ... Jack R Wands, MD, of Brown University , Dr. Steve Projan, PhD, ... MD, PhD, of Wayne State University, formerly a professor at Yale University School of ...
(Date:10/22/2019)... ... October 22, 2019 , ... Catalent, a global leader in clinical supply services, ... Integration, will participate in a panel session titled “Cell and Gene Therapy Logistics” at ... Gwen Hotel, Chicago, on Oct. 28-30, 2019. , The panel session, on Wednesday, Oct. ...
(Date:10/15/2019)... , ... October 14, 2019 , ... ARPR , an award-winning tech PR agency ... honored as a Health Care Agency of the Year in the Ragan’s Health Care ... as a finalist by Ragan’s. The firm also revealed today that its healthIT practice group ...
Breaking Biology Technology:
Cached News: