HOME >> BIOLOGY >> NEWS
New use for a cell toxin found to inhibit survival proteins in cancer cells

SEATTLE A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins in cancer cells. The research is a first step toward developing a molecularly-targeted drug that could eliminate cellular-level resistance to multiple types of chemotherapy and radiation therapy found in many types of cancers.

In a paper published today in the July 2007 issue of Molecular Cancer Therapeutics, scientists at Fred Hutchinson Cancer Research Center report that a modified version of antimycin called 2-Methoxy antimycin is selective in killing cells that have high levels of Bcl-2 and Bcl-xL proteins. The over expression of these proteins in many types of cancer cells correlates with resistance to chemotherapy and radiation therapy. Cells with normal levels of Bcl-2 or Bcl-xL are resistant to 2-Methoxy antimycin.

David M. Hockenbery, a member of the Hutchinson Centers Clinical Research Division and principal investigator for the study, and colleagues set up screening assays to look for small molecules or compounds that are selectively toxic to cells that over express Bcl-2 proteins. Higher expression of the target protein made cells more sensitive to the 2-Methoxy antimycin inhibitor. This is called a gain of function mechanism and is counterintuitive to the way most drugs work.

Our compound, 2-Methoxy antimycin, is the only Bcl-2 inhibitor reported with gain of function activity, which provides a therapeutic window between cancer cells with high expression of the proteins versus cells with normal expression, said Hockenbery, who is also a professor of medicine at the University of Washington Medical Center. This effect was preserved when 2-Methoxy antimycin was used in combination with other agents, and could lead to a targeted molecular therapy to enhance the effectiveness of cancer treatments.

Hockenbery said his groups approach illustrated the need
'"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
11-Jul-2007


Page: 1 2

Related biology news :

1. Children of smokers have more than 5 times higher levels of a nicotine toxin
2. Genome of Clostridium botulinum reveals the background to worlds deadliest toxin
3. Engineered protein effective against Staphylococcus aureus toxin
4. Anthrax paralyzes immune cells with lethal toxin, UF research shows
5. Gene that governs toxin production in deadly mold found
6. Bacterial response to oxidation studied as toxin barometer
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Sea creatures toxin could lead to promising cancer treatment
9. Algae toxin identification unravels fish-kill mystery
10. Red tide toxins leave beachgoers breathless
11. Study reveals molecular basis of botulism toxins deadly activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... September 06, 2018 , ... Sensors ... sister to show Sensors Expo & Conference , announces their partnership with ... to conduct an IoT Enabled Industrial IoT Certification Program. Taking place on October ...
(Date:8/31/2018)... (PRWEB) , ... August 30, 2018 , ... ... inhibitor residence times as a component of drug discovery programs. Longer-target engagement can ... residence times are low throughput, require expensive instrumentation, or require the alteration of ...
(Date:8/29/2018)... (PRWEB) , ... August 28, ... ... a radiopharmaceutical company unlocking the full power of positron emission tomography (PET), ... metal catalysis, Fuzionaire Dx is helping clinicians and researchers study and cure ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... Calif. (PRWEB) , ... August 28, 2018 , ... ... scientists from around the world, is proud to announce the launch of a new ... offers for a chance to win one of LabRoots most popular shirts. , Throughout ...
(Date:8/23/2018)... ... 2018 , ... Crucial Data Solutions, Inc. announces the release ... fully-featured app for electronic data capture (EDC) and electronic participant reported outcomes (ePRO) ... of the market share for mobile devices worldwide; in turn, this enables more ...
(Date:8/17/2018)... ... August 16, 2018 , ... The opening of the new Titusville ... Technical Services in 2016. Chemko had a well established local presence, servicing the Space ... on projects such as the ongoing work at the Mobile Launch Platform (MLP) in ...
(Date:8/14/2018)... ... August 13, 2018 , ... ... fume hoods and biological safety cabinets. In addition, Labconco produces other lab equipment, ... measure of its commitment to quality and consistency in design and manufacturing. ...
Breaking Biology Technology:
Cached News: