HOME >> BIOLOGY >> NEWS
New use for a cell toxin found to inhibit survival proteins in cancer cells

to look at how the proteins interact with everything else in the cell. By over expressing this protein, the cell is changed in some interesting ways. It creates a situation where the cell becomes dependent upon the protein, he said. Cancers can become addicted to certain proteins, so just by over expressing the protein the cell changes so that it cant live without that protein.

The next step in this research is to use the assays his lab developed to cast a wider net to find additional compounds that have similar properties to 2-Methoxy antimycin, Hockenbery said. This strategy has already yielded one additional Bcl-xL inhibitor with "gain of function" activity, reported in the Molecular Cancer Therapeutics paper. Funding for the study, 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition, came from the New Technology Development Fund administered by the Hutchinson Center. Additional key investigators in Hockenberys lab included Michael Manion, Ph.D., and Pam Schwartz, Ph.D., and John Fry.


'"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
11-Jul-2007


Page: 1 2

Related biology news :

1. Children of smokers have more than 5 times higher levels of a nicotine toxin
2. Genome of Clostridium botulinum reveals the background to worlds deadliest toxin
3. Engineered protein effective against Staphylococcus aureus toxin
4. Anthrax paralyzes immune cells with lethal toxin, UF research shows
5. Gene that governs toxin production in deadly mold found
6. Bacterial response to oxidation studied as toxin barometer
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Sea creatures toxin could lead to promising cancer treatment
9. Algae toxin identification unravels fish-kill mystery
10. Red tide toxins leave beachgoers breathless
11. Study reveals molecular basis of botulism toxins deadly activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/30/2017)... 30, 2017 Trends, opportunities and forecast in ... by technology (fingerprint, AFIS, iris recognition, facial recognition, hand ... by end use industry (government and law enforcement, commercial ... banking, and others), and by region ( North ... Asia Pacific , and the Rest of ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... ... 2017 , ... Sonic Manufacturing Technologies is proud to be ... solar system on its roof top. “We will be independent of the grid ... stated. The company’s proud history of social responsibility and participation in the preservation ...
(Date:7/14/2017)... Maine (PRWEB) , ... July 13, 2017 , ... ... D-Dimer linearity and calibration verification test kit has received US FDA 510 (k) ... in a human plasma matrix, evaluates D-Dimer. Each VALIDATE® D-Dimer kit, prepared using ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... Thousands of ... and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie to compete ... to earn spots on US teams that participate in world championships. , RC Pylon ...
(Date:7/13/2017)... ... July 13, 2017 , ... In’Tech Medical SAS ( http://www.intech-medical.com ... the completion of a major transaction with Eurazeo PME. The reputable French private ... alliance fuels In’Tech Medical’s service offerings while leveraging the company’s manufacturing expertise and ...
Breaking Biology Technology:
Cached News: