HOME >> BIOLOGY >> NEWS
New use for a cell toxin found to inhibit survival proteins in cancer cells

to look at how the proteins interact with everything else in the cell. By over expressing this protein, the cell is changed in some interesting ways. It creates a situation where the cell becomes dependent upon the protein, he said. Cancers can become addicted to certain proteins, so just by over expressing the protein the cell changes so that it cant live without that protein.

The next step in this research is to use the assays his lab developed to cast a wider net to find additional compounds that have similar properties to 2-Methoxy antimycin, Hockenbery said. This strategy has already yielded one additional Bcl-xL inhibitor with "gain of function" activity, reported in the Molecular Cancer Therapeutics paper. Funding for the study, 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition, came from the New Technology Development Fund administered by the Hutchinson Center. Additional key investigators in Hockenberys lab included Michael Manion, Ph.D., and Pam Schwartz, Ph.D., and John Fry.


'"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
11-Jul-2007


Page: 1 2

Related biology news :

1. Children of smokers have more than 5 times higher levels of a nicotine toxin
2. Genome of Clostridium botulinum reveals the background to worlds deadliest toxin
3. Engineered protein effective against Staphylococcus aureus toxin
4. Anthrax paralyzes immune cells with lethal toxin, UF research shows
5. Gene that governs toxin production in deadly mold found
6. Bacterial response to oxidation studied as toxin barometer
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Sea creatures toxin could lead to promising cancer treatment
9. Algae toxin identification unravels fish-kill mystery
10. Red tide toxins leave beachgoers breathless
11. Study reveals molecular basis of botulism toxins deadly activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... When a ... the response was swift and efficient thanks to the continuing efforts of members ... up of more than 50 stakeholders, including officials from area counties and cities, ...
(Date:9/20/2017)... ... 20, 2017 , ... Cybrexa Therapeutics , a start-up ... role of chief scientific officer. In this role, Dr. Paralkar will lead the ... CEO, Per Hellsund. , “I was impressed with Cybrexa’s revolutionary technology and excellent ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... the effects of exoskeleton-assisted walking on gait parameters and neuromuscular activity in ... adaptations during a robotic powered exoskeleton assisted walking session" (doi:10.1080.10790268.2017.1314900) was epublished ...
(Date:9/19/2017)... , ... September 19, 2017 , ... ... accurately automates the most dangerous step of sample prep for metals digestion—the addition ... provide automation at an affordable price. The system is ideal for any laboratory ...
Breaking Biology Technology:
Cached News: