HOME >> BIOLOGY >> NEWS
New use for a cell toxin found to inhibit survival proteins in cancer cells

to look at how the proteins interact with everything else in the cell. By over expressing this protein, the cell is changed in some interesting ways. It creates a situation where the cell becomes dependent upon the protein, he said. Cancers can become addicted to certain proteins, so just by over expressing the protein the cell changes so that it cant live without that protein.

The next step in this research is to use the assays his lab developed to cast a wider net to find additional compounds that have similar properties to 2-Methoxy antimycin, Hockenbery said. This strategy has already yielded one additional Bcl-xL inhibitor with "gain of function" activity, reported in the Molecular Cancer Therapeutics paper. Funding for the study, 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition, came from the New Technology Development Fund administered by the Hutchinson Center. Additional key investigators in Hockenberys lab included Michael Manion, Ph.D., and Pam Schwartz, Ph.D., and John Fry.


'"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
11-Jul-2007


Page: 1 2

Related biology news :

1. Children of smokers have more than 5 times higher levels of a nicotine toxin
2. Genome of Clostridium botulinum reveals the background to worlds deadliest toxin
3. Engineered protein effective against Staphylococcus aureus toxin
4. Anthrax paralyzes immune cells with lethal toxin, UF research shows
5. Gene that governs toxin production in deadly mold found
6. Bacterial response to oxidation studied as toxin barometer
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Sea creatures toxin could lead to promising cancer treatment
9. Algae toxin identification unravels fish-kill mystery
10. Red tide toxins leave beachgoers breathless
11. Study reveals molecular basis of botulism toxins deadly activity

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New use for cell toxin found inhibit survival proteins cancer cells

(Date:10/29/2014)... and environmental, have been blamed for increasing the ... as a family history of schizophrenia, are widely ... gondii , a parasite transmitted by soil, undercooked ... skepticism. , A new study by Gary Smith, ... University of Pennsylvania,s School of Veterinary Medicine, used ...
(Date:10/29/2014)... all the rage. Thousands of scientists worldwide are conducting ... titanium dioxide nanoparticles from sun creams can get through ... from electronic products are as hazardous for the lungs ... food can get into the blood via the intestinal ... are flowing – and the number of scientific projects ...
(Date:10/29/2014)... news release is available in German . ... like another: Gabriela Cabral and Peter Schlögelhofer at the ... Vienna and the Medical University of Vienna dived into ... revealed that these plants display an inversion of the ... in the scientific journal Nature Communications . , ...
Breaking Biology News(10 mins):Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3Meiotic cell division 'the other way round' 2
(Date:10/30/2014)... 30, 2014 Spartan Bioscience announced today ... CYP2C19 System . It detects CYP2C19 genetic mutations in ... , The Spartan RX CYP2C19 System is the first ... approved in Canada. Due to the system’s ease of ... used by healthcare professionals such as doctors, nurses, pharmacists, ...
(Date:10/30/2014)... INDIANAPOLIS , Oct. 30, 2014 A ... Battelle Technology Partnership Practice, takes an in-depth look at ... innovation outputs that have resulted over two different time ... also provides a view of future opportunities for investment ... Indiana report shows gains in innovation ...
(Date:10/27/2014)... The new research report, “Gas ... Medium), Sub-type (Primary & Secondary), and End-User (Transmission ... & Power Generation) - Trends and Forecasts to ... analysis and forecasting of the market size. , ... 52 Figures spread through 146 Pages and in-depth ...
(Date:10/27/2014)... New Q4-2014 incentives help SoundConnect ... industry leading unified communication and collaboration provider, launches ... deliver cloud-based audio and web/video conferencing solutions to ... SoundConnect’s Q4 incentive partners will earn ... conferencing licenses sold, now through December 31st, 2014. ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4SoundConnect Unveils Q4 Partner Incentives 2
Cached News: