HOME >> BIOLOGY >> NEWS
New view of cancer: 'Epigenetic' changes come before mutations

A Johns Hopkins researcher, with colleagues in Sweden and at the Fred Hutchinson Cancer Research Center, suggests that the traditional view of cancer as a group of diseases with markedly different biological properties arising from a series of alterations within a cell's nuclear DNA may have to give way to a more complicated view. In the January issue of Nature Reviews Genetics, available online Dec. 21, he and his colleagues suggest that cancers instead begin with "epigenetic" alterations to stem cells.

"We're not contradicting the view that genetic changes occur in the development of cancers, but there also are epigenetic changes and those come first," says lead author Andrew Feinberg, M.D., M.P.H., King Fahd Professor of Medicine and director of the Center for Epigenetics in Common Human Disease at Johns Hopkins.

Cells affected by epigenetic changes look normal under a microscope at low levels of resolution, Feinberg says, "but if you look carefully at the genome, you find there are subtle changes." By tracking these changes, he suggests, doctors potentially could treat people before tumors develop in much the same way as cardiologists prescribe cholesterol-lowering drugs to help prevent heart disease.

Epigenetic changes -- those that don't affect the gene's sequence of DNA but change the gene in other ways -- influence a wide variety of human diseases, including cancer, birth defects and psychiatric conditions. Epigenetic alterations include the turning off or quieting of genes that normally suppress cancer and the turning on of oncogenes to produce proteins that set off malignant behavior.

Epigenetic changes are found in normal cells of patients with cancer and are associated with cancer risk, Feinberg notes.

As one example, in a study published in the Feb. 24, 2005, online version of Science, Feinberg and colleagues in the United States, Sweden and Japan reported that mice engineered to have a double dose of insulin-
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
21-Dec-2005


Page: 1 2

Related biology news :

1. Soy estrogens and breast cancer: Researcher offers overview
2. Finding a cure for cancer: The holy grail of science
3. Treatment disconnect in kidney cancer: Rising mortality despite more small tumors, more surgery
4. Getting ahead of cancer: SPECT/Spiral CT technology enhances bone scanning, earlier diagnosis
5. Diabetes and cancer: Alpha connection
6. Tobacco-related cancer: How does it happen?
7. Building a better mouse model of lung cancer: FHIT counts
8. Acute sleep deprivation leads to changes in nighttime urine production for men and women
9. Marine phytoplankton changes form to protect itself from different predators
10. ENCODE map changes view of the human genome landscape
11. Small-scale agricultural changes may help eradicate widespread disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2016)... DUBLIN , Nov 15, 2016 Research ... - Global Forecast to 2021" report to their offering. ... ... reach USD 16.18 Billion by 2021 from USD 6.21 Billion in ... Growth of the bioinformatics market is driven by ...
(Date:11/14/2016)... Nov. 14, 2016  Based on its ... Frost & Sullivan recognizes FST Biometrics with ... for Visionary Innovation Leadership. FST Biometrics emerged ... identification market by pioneering In Motion Identification ... instant, seamless, and non-invasive verification. This patented ...
(Date:6/22/2016)... , June 22, 2016  The American College of ... Trade Show Executive Magazine as one of the fastest-growing ... May 25-27 at the Bellagio in Las Vegas ... the highest percentage of growth in each of the following ... exhibiting companies and number of attendees. The 2015 ACMG Annual ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... HOWELL, N.J. , Dec. 8, 2016 /PRNewswire/ ... aquatic augmentation remediation technologies and selected NewTechBio,s NT-MAX ... , a microbial based beneficial bacteria, in conjunction ... Inc., to correct deficiencies with National Pollutant Discharge ... basin 281-8H has experienced a steady history of ...
(Date:12/8/2016)...  Partnering to fuel Philadelphia,s ... Southeastern Pennsylvania (" Ben Franklin ... Independence Blue Cross; and Safeguard Scientifics ("Safeguard") (NYSE: ... $6 million funding initiative over a four year period ... to a burgeoning economic vitality in digital health, ...
(Date:12/7/2016)... ... December 07, 2016 , ... ACEA Biosciences, ... escalation and expansion clinical trial for its lead drug candidate, AC0010, at the ... the trial was to determine the safety, antitumor activity, and recommended phase II ...
(Date:12/7/2016)... ... December 07, 2016 , ... Huffman ... has become a Wonderware Certified System Integrator Partner. Huffman Engineering is the ... Software. , “The System Integrator Partner certification gives customers confidence that our engineers ...
Breaking Biology Technology:
Cached News: