HOME >> BIOLOGY >> NEWS
Newborn neurons like to hang with the 'in' crowd

LA JOLLA, CA Like any new kid on the block that tries to fit in, newborn brain cells need to find their place within the existing network of neurons. The newcomers jump right into the fray and preferentially reach out to mature brain cells that are already well connected within the established circuitry, report scientists at the Salk Institute for Biological Studies in the online edition of Nature Neuroscience.

At first, they gingerly sniff out pre-existing connections between brain cells but as the new neurons mature over time they get emboldened and muscle out the old guys. "Adding new neurons could be a very problematic process if newborn cells would make connections all over the place," explains Fred H. Gage, Ph.D., a professor in the Gene Expression Laboratory and the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases. "But if they are only replacing already existing connections there is less chance of error," he adds.

Neurons make contact via specialized structures called synapses. As a signal traveling along a nerve branch arrives at the pre-synaptic area, it releases a chemical signal. The signaling molecules travel across the synapse and induce a signal on the neighboring, receiving nerve fiber or dendrite. A typical neuron sports about 7,000 synapses through which it stays in touch with roughly 1,000 other cells. But just how young neurons make their presence known and hook up with already well-connected elders has been unclear.

"If you have hopes that one day neuronal stem cells can replace damaged neurons in neurodegenerative diseases such as Alzheimer's or Parkinson's disease you have to ensure that these cells make proper connections, form functional synapses and integrate into the rest of the brain," says postdoctoral fellow Nicolas Toni, Ph.D., who headed the current study.

To figure out how the newcomers do it, the Salk researchers injected a virus carrying the gene for green fl
'"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100, ext. 1340
Salk Institute
7-May-2007


Page: 1 2 3

Related biology news :

1. Newborns with respiratory distress potentially have rare genetic disease
2. Newborn screening can cause unnecessary parental stress
3. Newborn hearing screening programs may benefit from the standardization of testing protocols
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. Stem cell therapy rescues motor neurons in ALS model
6. Neurons for numerosity: Parietal neurons sum up individual items in a group
7. Nicotine rush hinges on sugar in neurons
8. Turn-ons and turn-offs for neurons
9. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
10. Parkinsons protein protects neurons from stress induced cell death
11. Role of noise in neurons

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... Precision Periodontics and Implant ... and LAPIP™ laser treatments. Drs. Hoge and Zalewsky are members of an elite ... and less painful option that produces real results. , "Like many of my ...
(Date:9/22/2017)... ... 2017 , ... The effectiveness of a new wound healing ... in the United States. (clinicaltrials.gov : NCT02973893) , To find out more about ... nearest participating clinic here https://factor-therapeutics.com/clinical-trials/ and discuss your condition with one ...
(Date:9/21/2017)... ... ... Dr. Greg Leyer, Chief Scientific Officer of UAS Labs, will be presenting at ... in the Probiotics Resource Center, Mandalay Bay Expo Hall. , “I am very ... shown impressive data in areas outside the gut including heart health, Vitamin D status, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Colpitts Clinical ... of the portal includes new features that facilitate streamlined and compliant communication, file ... remain at the forefront of medical advancements, they rely on efficiencies to help ...
Breaking Biology Technology:
Cached News: