HOME >> BIOLOGY >> NEWS
Newborns with respiratory distress potentially have rare genetic disease

Newborns with respiratory distress should be evaluated for primary ciliary dyskinesia, a rare genetic disease that has features similar to cystic fibrosis, says Thomas Ferkol, M.D., from Washington University School of Medicine in St. Louis. He reports finding that about 80 percent of patients with primary ciliary dyskinesia (PCD) have a history of newborn respiratory distress.

"The diagnosis of PCD requires a high index of suspicion, but PCD must be considered in any term newborn who develops respiratory distress or persistent hypoxemia (low oxygen in the blood), especially those who have reversed internal organs or an affected sibling," says Ferkol, director of the Division of Pediatric Allergy and Pulmonary Medicine at Washington University School of Medicine and St. Louis Children's Hospital.

Reviewing published reports, Ferkol and Margaret Leigh, M.D., professor of pediatrics at the University of North Carolina at Chapel Hill (UNC), found that neonatal respiratory distress was a common clinical symptom of PCD, a chronic airway disease that affects about 1 in 15,000 children. Their findings appeared in the December issue of Seminars in Perinatology.

Also known as immotile cilia syndrome, ciliary aplasia or Kartagener Syndrome, PCD causes persistent wheezing and cough in children and is associated with recurrent or persistent sinus and ear infections. Half of patients with PCD have reversed internal organs, called situs inversus, and males are usually infertile.

In PCD patients, the cilia, tiny hairs that move mucus, bacteria and particulates out of the respiratory tract, including the lungs, middle ear and paranasal sinuses, have abnormal or no motion. As a result, the airways become obstructed and infected, which incites a destructive inflammatory process in those organs. Cilia are also present in the female reproductive system, central nervous system and gut.

"The tricky thing about this disease is that many
'"/>

Contact: Beth Miller
millerbe@msnotes.wustl.edu
314-286-0119
Washington University School of Medicine
20-Feb-2007


Page: 1 2 3

Related biology news :

1. Wurst ensures that the respiratory system works
2. Genetic defect links respiratory disease and congenital heart disease
3. Study of unexplained respiratory infections leads researchers to new virus
4. Study identifies risk factors for spread of respiratory infections in hospitals
5. Long-term marijuana smoking leads to respiratory complaints
6. Nearly a quarter of children are especially susceptible to respiratory illness if they are exposed to second-hand smoke
7. Study shows how respiratory disorder slows some racehorses
8. Scripps research scientists discover new key to pulmonary edema in respiratory distress syndrome
9. Quantum dots provide a faster, more sensitive method for detecting respiratory viral infections
10. Immune systems distress signal tells bacteria when to strike back
11. Recurrent miscarriages: Could prednisolone reduce the occurrence of this distressing condition?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/6/2017)... MATEO, Calif. , March 6, 2017 /PRNewswire/ ... marketing and sales technology, today announced Predictive Sales ... solution for infusing actionable sales intelligence into Salesforce. ... to automatically enable their sales organizations with deep ... messages that allow for intelligent engagement. Predictive Sales ...
(Date:3/2/2017)... MELBOURNE, Australia , March 2, 2017 ... Therapeutics Ltd (ASX: CYP), has signed an agreement ... researchers from the Monash Biomedicine Discovery Institute and Department ... , to conduct a further preclinical study to support ... the treatment of asthma.  Asthma is ...
(Date:2/28/2017)... Spanien, 27. Februar 2017  EyeLock LLC, ein marktführendes ... seine erstklassige biometrische Lösung zur Iris-Erkennung auf ... X16 LTE auf dem Mobile World Congress ... Qualcomm-Stand in Halle 3, Stand 3E10, vorstellen. ... Sicherheitsplattform Qualcomm Haven™ – eine Kombination aus ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... 28, 2017 Dr. Chris Yu ... corporation Anpac Bio-Medical Science Company , announced ... record, processing and reporting over 40,000 cases worldwide ... (CDA) liquid biopsy tests. Described ... Summit publications, Anpac Bio,s CDA medical devices and ...
(Date:3/28/2017)... ... March 28, 2017 , ... Currently symptomatic therapies for Parkinson’s ... study published in STEM CELLS suggests that human neural stem cell (hNSC) transplantation ... produce more neural cells. , Strategies involving transplantation of these cells into ...
(Date:3/28/2017)... 2017 /PRNewswire/ -RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSXV: RP) ... safety and clinical data from its phase 1/2 tendon repair ... follicle-derived fibroblasts (RCT-01) as a treatment for Achilles tendinosis. ... The ... profile at 6 months and showed no serious adverse events ...
(Date:3/27/2017)... , March 27, 2017 Roka Bioscience, Inc. (NASDAQ: ... solutions for the detection of foodborne pathogens,  today announced that ... & Company Spring 2017 Convention on March 29 at 9:50am ... Marriott Marquis. About Roka Bioscience ... Roka Bioscience ...
Breaking Biology Technology:
Cached News: