HOME >> BIOLOGY >> NEWS
Newly created cancer stem cells could aid breast cancer research

CAMBRIDGE, Mass. (August 13, 2007) In some ways, certain tumors resemble bee colonies, says pathologist Tan Ince. Each cancer cell in the tumor plays a specific role, and just a fraction of the cells serve as queens, possessing the unique ability to maintain themselves in an unspecialized state and seed new tumors. These cells can also divide and produce the worker cells that form the bulk of the tumor.

These queens are cancer stem cells. Now the lab of Whitehead Member Robert Weinberg has created such cells in a Petri dish by isolating and transforming a particular population of cells from human breast tissue. After being injected with just 100 of these transformed cells, mice developed tumors that metastasized (spread to distant tissues).

The operational definition of a cancer stem cell is the ability to initiate a tumor, so these are cancer stem cells, declares Weinberg, who is also an MIT professor of biology.

Ince didnt set out to engineer these potent cells. As a post-doctoral researcher in the Weinberg lab and gynecologic pathologist at Brigham and Womens Hospital, he was simply trying to create breast cancer models that look like real human tumors under the microscope and behave like those seen in many patients.

In more than 90 percent of human breast tumors, cancer cells resemble those lining our bodys cavities. A trained pathologist can spot the similarities under a microscope. But the cancer cells previously engineered from normal breast cells for laboratory studies looked different. Ince suspected that researchers were transforming the wrong type of cells.

Now an independent investigator at Brigham and Womens Hospital and an instructor at Harvard Medical School, Ince developed a recipe for a new chemically defined culture medium and managed to grow a different type of human breast cell that ordinarily dies in culture. He transformed it into a cancer cell by inserting specific genes through a standard
'"/>

Contact: Alyssa Kneller
kneller@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
13-Aug-2007


Page: 1 2 3

Related biology news :

1. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
2. Newly discovered platform for processing dietary fat
3. Newly discovered West Coast arrhythmias cause
4. Newly discovered fish named after New York aquarium biologist
5. Newly discovered immune defense may be impaired in CF airways
6. Newly identified strains of Chlamydia trachomatis could produce new diseases
7. Newly discovered proteins associated with cystic fibrosis
8. Newly discovered gene may hold clues to evolution of human brain capacity
9. Newly identified protein complex sheds light on axon growth mechanism
10. Newly discovered protein could hold key to preventing heart disease
11. Newly discovered protein kills anthrax bacteria by exploding their cell walls

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... , ... August 06, 2020 , ... ... participate in the prestigious National STEM Scholar Program, a unique professional development program ... and project support for middle school science teachers nationwide. , Created in partnership ...
(Date:8/3/2020)... ... 2020 , ... Accumen Inc. is helping healthcare get better, ... Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has been ... 10 years. Early in the COVID-19 crisis, we identified supply chain gaps and ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions ... as MediVet Biologics since its formation in 2016, the company is relaunching itself under ... build on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
(Date:7/31/2020)... ... 2020 , ... eSource has long been touted as the solution to high ... eSource, the reasons it did not take off as quickly as people initially expected, ... is moving towards capturing data electronically for clinical trials and then repurposing it for ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed ... Manager Regulatory Solutions, in a one hour live webinar on Thursday, August ... in China for drugs and medical devices. Specifically, for medical devices, the NMPA has ...
Breaking Biology Technology:
Cached News: