HOME >> BIOLOGY >> NEWS
Newly-discovered class of genes determines and restricts stem cell fate

(Philadelphia, PA) Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes dubbed pangenes can both govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecular control of these genes has implications for therapies that involve tissue regeneration.

The researchers found that Pax3, a gene critical in embryonic development of melanocytes cells that make and store the pigments in the skin and hair is also expressed in adult stem cells in the skin.

"Our findings told us that a recapitulation of an embryonic program is occurring in resident stem cells in adult skin," explains Jon Epstein, MD, Professor of Medicine, Cardiovascular Division. "These few rare stem cells were expressing genes that previously had only been known to be expressed in a developing embryo. That was the first clue that we were on to something new." Epstein and colleagues report their findings in the February 24th issue of Nature.

The scientists found that Pax3 plays dual and somewhat seemingly contradictory roles in adult stem cells: it directs them to become melanocytes, but simultaneously prevents them from differentiating completely. "It gets the show going, but at the same time, prevents the final act," says Epstein. "I call this dual function a "biological capacitor," because Pax3 tells the cell: Get ready to go, but at the same time won't let it proceed."

Pangenes Express Behavioral Qualities of Pan and Peter Pan

Epstein notes that this research is conceptually new since he suggests that a single gene can both tell a cell what it should become and restrict its fate by preventing differentiation. The ability of a single biochemical factor or complex of factors to have this dual role may represent a new general paradigm for developmental and stem
'"/>

Contact: Ed Federico
ed.federico@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
23-Feb-2005


Page: 1 2

Related biology news :

1. Damon Runyon names new class of rising stars in cancer research
2. Pendulum love, science class gender gaps, musical mind mirrors, and unparticle physics
3. New algorithms classify outcomes of nonsmall cell lung cancer patients
4. UCLA molecular biologists convert protein sequences into classical music
5. Double honor recognises world-class science and spin-out success
6. Misclassified for centuries, medicinal leeches found to be 3 distinct species
7. Fighting to keep Darwin in the classroom
8. Funding boost for QUT world-class banana research
9. Protein folding physics, nanohandles, sunscreen for algae and classical quantum weirdness
10. New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds
11. Free access to world-class biological databases for European science thanks to FELICS

Post Your Comments:
(Date:2/5/2015)... , Jan. 28, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... the upcoming RedChip Global Online CEO Conference on January ... Gino Pereira , CEO of NXT-ID will ... lead product, the Wocket smart wallet and its full ...
(Date:2/5/2015)... 30, 2015  It is gratifying to see that ... for genomic science as a means to better understand ... treatment.  I was honored to participate in today,s White ... program. Since the 1980s my teams ... the first sequenced genome of a free living organism, ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the ... report to their offering. , The ... individual is who she/he is claiming to be, and for ... unique physical characteristics, such as fingerprint, hand or palm print, ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
(Date:2/26/2015)... 2015 RURO, Inc., a leading LIMS, ... 6.2 – the latest update to the bestselling commercial-off-the-shelf ... of a quick and easy method to gain better ... version, RURO engineering has enhanced the system’s support for ... amounts of sample records. , "FreezerPro has become ...
(Date:2/26/2015)...  Dyadic International, Inc. ("Dyadic") (OTCQX: DYAI), a ... are used to develop, manufacture and sell enzymes ... biopharmaceutical and industrial enzyme industries, announced today that ... ending December 31, 2014 after market close on ... conference call that day at 5:00 p.m. Eastern ...
(Date:2/26/2015)... THOUSAND OAKS, Calif. , Feb. 26, 2015 /PRNewswire/ ... has achieved Gold Partner status in Oracle PartnerNetwork. In ... Oracle for its commitment to establish Oracle-related knowledge in ... addressing the challenges of joint customers. Originally ... allows researchers to rapidly zoom in and out of ...
(Date:2/26/2015)... SAN DIEGO , Feb. 26, 2015  Epic ... Prahalad , Ph.D. will present at the 35th Annual ... 2015 at 10:00 a.m. EST in the MIT Room, 3rd Floor. ... Copley Place Hotel in Boston, Mass. Epic is ... real-time detection of genomic and proteomic changes that occur ...
Breaking Biology Technology:RURO Releases FreezerPro® version 6.2 2Dyadic International To Announce Fourth Quarter 2014 Financial Results And Host Conference Call On Wednesday, March 11, 2015 2Dyadic International To Announce Fourth Quarter 2014 Financial Results And Host Conference Call On Wednesday, March 11, 2015 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4Epic Sciences to Present at 35th Annual Cowen and Company Health Care Conference 2
Cached News: