HOME >> BIOLOGY >> NEWS
Newly discovered protein could hold key to preventing heart disease

A newly discovered gene known as MCPIP could provide scientists with the key to developing treatments for preventing inflammation that can cause heart disease, University of Central Florida researchers have discovered.

A research team led by Pappachan Kolattukudy, dean of the UCF Burnett College of Biomedical Sciences, found that the levels of MCPIP increased in mice as their blood vessels became inflamed and heart disease began to develop. The formation of MCPIP leads to the death of healthy cells, so treatments that block that formation could prove effective for heart disease.

The researchers are trying to discover the molecular changes that occur as heart disease develops. Better understanding those molecular changes would help with the development of drugs that can either prevent or treat the disease.

The team's findings are published in the May 12 issue of Circulation Research, the journal of the American Heart Association. The research is funded through a $1.4 million grant from the National Institutes of Health.

The laboratory mice developed heart disease in a way similar to how it forms in humans, which suggests that the findings could hold promise for treating human heart disease. However, more research is needed to evaluate whether the same results found in mice could be expected in humans.

The UCF research team already has found that MCPIP is elevated in human hearts suffering ischemic heart failure.

MCPIP is formed when an often-studied protein called MCP-1 binds to receptors. The MCP-1 protein helps to attract white blood cells known as monocytes to infected and injured areas of the body. The monocytes then attack bacteria and help the body fight diseases.

But that process also produces several known and unknown proteins. The researchers focused on MCPIP, one of the previously unknown proteins, because they discovered links between it and the deaths of healthy cells adjacent to the infected one
'"/>

Contact: Chad Binette
cbinette@mail.ucf.edu
407-823-6312
University of Central Florida
17-May-2006


Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
3. Newly discovered platform for processing dietary fat
4. Newly discovered West Coast arrhythmias cause
5. Newly discovered fish named after New York aquarium biologist
6. Newly discovered immune defense may be impaired in CF airways
7. Newly identified strains of Chlamydia trachomatis could produce new diseases
8. Newly discovered proteins associated with cystic fibrosis
9. Newly discovered gene may hold clues to evolution of human brain capacity
10. Newly identified protein complex sheds light on axon growth mechanism
11. Newly discovered protein kills anthrax bacteria by exploding their cell walls

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2017)...  Wake Forest Baptist Medical Center today announced Julie Ann ... officer (CEO). Freischlag joins the medical center on May ... M.D., who last year announced that he would transition ... leading it since 2008.   As CEO, ... Baptist,s academic health system, which includes Wake Forest School ...
(Date:2/13/2017)... -- Former 9/11 Commission border counsel and Special Counsel ... of Identity Strategy Partners, LLP, today releases the ... Order: Protecting the Nation From Foreign Terrorist Entry Into ... President Trump,s ,Travel Ban, Executive Order gains more notoriety ... travel ban, it is important that our national discourse ...
(Date:2/9/2017)... The biomass boiler market report by Transparency Market Research ... in terms of revenue (US$ Mn) based on the ... boilers has been segmented on the basis of feedstock ... based on feedstock type, has been segmented into woody ... urban residues, and others. On the basis of product ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... , March 23, 2017 According to a ... and derivatives market is fragmented due to the presence of a large ... Proliant, Thermo Fisher , and Sigma-Aldrich, compete with each other ... companies, collectively, held more than 76% of this market in 2016.  ... As of now, ...
(Date:3/23/2017)... 2017 In today,s pre-market research, ... the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate ... SYN), and Regulus Therapeutics Inc. (NASDAQ: RGLS ... Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn ... at: ...
(Date:3/22/2017)... Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today announced a ... Biobank and GSK to generate genetic sequence data from the ... will enable researchers to gain valuable insights to support advances ... of serious and life threatening diseases. ... Genetic evidence has revolutionized ...
(Date:3/22/2017)... 2017  Ascendis Pharma A/S (Nasdaq: ASND), a ... to address significant unmet medical needs in rare ... year ended December 31, 2016. ... as we broadened our pipeline and pursued our ... company with an initial focus on endocrinology," said ...
Breaking Biology Technology:
Cached News: