HOME >> BIOLOGY >> NEWS
Newly discovered protein could hold key to preventing heart disease

A newly discovered gene known as MCPIP could provide scientists with the key to developing treatments for preventing inflammation that can cause heart disease, University of Central Florida researchers have discovered.

A research team led by Pappachan Kolattukudy, dean of the UCF Burnett College of Biomedical Sciences, found that the levels of MCPIP increased in mice as their blood vessels became inflamed and heart disease began to develop. The formation of MCPIP leads to the death of healthy cells, so treatments that block that formation could prove effective for heart disease.

The researchers are trying to discover the molecular changes that occur as heart disease develops. Better understanding those molecular changes would help with the development of drugs that can either prevent or treat the disease.

The team's findings are published in the May 12 issue of Circulation Research, the journal of the American Heart Association. The research is funded through a $1.4 million grant from the National Institutes of Health.

The laboratory mice developed heart disease in a way similar to how it forms in humans, which suggests that the findings could hold promise for treating human heart disease. However, more research is needed to evaluate whether the same results found in mice could be expected in humans.

The UCF research team already has found that MCPIP is elevated in human hearts suffering ischemic heart failure.

MCPIP is formed when an often-studied protein called MCP-1 binds to receptors. The MCP-1 protein helps to attract white blood cells known as monocytes to infected and injured areas of the body. The monocytes then attack bacteria and help the body fight diseases.

But that process also produces several known and unknown proteins. The researchers focused on MCPIP, one of the previously unknown proteins, because they discovered links between it and the deaths of healthy cells adjacent to the infected one
'"/>

Contact: Chad Binette
cbinette@mail.ucf.edu
407-823-6312
University of Central Florida
17-May-2006


Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
3. Newly discovered platform for processing dietary fat
4. Newly discovered West Coast arrhythmias cause
5. Newly discovered fish named after New York aquarium biologist
6. Newly discovered immune defense may be impaired in CF airways
7. Newly identified strains of Chlamydia trachomatis could produce new diseases
8. Newly discovered proteins associated with cystic fibrosis
9. Newly discovered gene may hold clues to evolution of human brain capacity
10. Newly identified protein complex sheds light on axon growth mechanism
11. Newly discovered protein kills anthrax bacteria by exploding their cell walls

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Newly discovered protein could hold key preventing heart disease

(Date:3/11/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ... Control Market by Product, Application & By Geography - ... their offering. , This report predicts that ... billion by 2020, with an estimated CAGR of 10.6%. ... products types such as contact cards & readers, contactless ...
(Date:3/10/2015)... Conn. , March 10, 2015  NXT-ID, ... ("NXT-ID" or the "Company"), a biometric authentication company ... the company,s Wocket™ smart wallet has been named ... by Rethink Modern. Rethink Modern ( ... and innovative items for your home and lifestyle that have ...
(Date:3/2/2015)... March 2, 2015  Businesses have a new ... company Tharon Rankins Enterprises has announced the launch ... ultra-safe way for businesses to protect their customers, ... Beconux is a biometric transaction ... Functioning similarly to an ATM machine, the new ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Personal Data Protection Company Launches New Product 2
(Date:3/26/2015)... SAN DIEGO , March 26, 2015  BioNano ... the appointment of  Terry Salyer as chief commercial ... building highly effective, worldwide sales teams in life sciences. ... Irys ® System, a genome-mapping platform to assemble ... and investigate structural variations. To date, 32 institutions located ...
(Date:3/26/2015)... 26, 2015 PAREXEL International Corporation ... clinical research organization , announced today that ... to acquire all of the business assets of ... provider of specialized pharmacovigilance services, based in ... detection, assessment, monitoring, and prevention of adverse ...
(Date:3/26/2015)... Ale Gicqueau, Founder and President of ... Affairs at Align Technology, on “ Conducting Postmarket Registries ... 2015 Global Conference and Exhibition on April 25th through ... During the poster presentation, Ale Gicqueau and Victor Chen ... Postmarket Registry, the requirements and resources to conduct the ...
(Date:3/25/2015)... Balaton, MN (PRWEB) March 26, 2015 ... an upcoming episode of American Farmer, airing for the ... RFD-TV. The segment of American Farmer will explore the ... Agnition provides crop producers with a patented Microbial Catalyst™ ... farms and greater yields. The segment will air again ...
Breaking Biology Technology:BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2
Cached News: