HOME >> BIOLOGY >> NEWS
Newly discovered protein could hold key to preventing heart disease

A newly discovered gene known as MCPIP could provide scientists with the key to developing treatments for preventing inflammation that can cause heart disease, University of Central Florida researchers have discovered.

A research team led by Pappachan Kolattukudy, dean of the UCF Burnett College of Biomedical Sciences, found that the levels of MCPIP increased in mice as their blood vessels became inflamed and heart disease began to develop. The formation of MCPIP leads to the death of healthy cells, so treatments that block that formation could prove effective for heart disease.

The researchers are trying to discover the molecular changes that occur as heart disease develops. Better understanding those molecular changes would help with the development of drugs that can either prevent or treat the disease.

The team's findings are published in the May 12 issue of Circulation Research, the journal of the American Heart Association. The research is funded through a $1.4 million grant from the National Institutes of Health.

The laboratory mice developed heart disease in a way similar to how it forms in humans, which suggests that the findings could hold promise for treating human heart disease. However, more research is needed to evaluate whether the same results found in mice could be expected in humans.

The UCF research team already has found that MCPIP is elevated in human hearts suffering ischemic heart failure.

MCPIP is formed when an often-studied protein called MCP-1 binds to receptors. The MCP-1 protein helps to attract white blood cells known as monocytes to infected and injured areas of the body. The monocytes then attack bacteria and help the body fight diseases.

But that process also produces several known and unknown proteins. The researchers focused on MCPIP, one of the previously unknown proteins, because they discovered links between it and the deaths of healthy cells adjacent to the infected one
'"/>

Contact: Chad Binette
cbinette@mail.ucf.edu
407-823-6312
University of Central Florida
17-May-2006


Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
3. Newly discovered platform for processing dietary fat
4. Newly discovered West Coast arrhythmias cause
5. Newly discovered fish named after New York aquarium biologist
6. Newly discovered immune defense may be impaired in CF airways
7. Newly identified strains of Chlamydia trachomatis could produce new diseases
8. Newly discovered proteins associated with cystic fibrosis
9. Newly discovered gene may hold clues to evolution of human brain capacity
10. Newly identified protein complex sheds light on axon growth mechanism
11. Newly discovered protein kills anthrax bacteria by exploding their cell walls

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... (PRWEB) , ... June 24, 2020 , ... ... cloud-based enterprise software and software-driven clinical data services that accelerate drug development, is ... low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid ... Ltd, a UK supplier and manufacturer of innovative portable renewable energy equipment, have ... the fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... pleased to announce the next event in a series of TOPIQ webinars, which ... TOPIQ series of webinars was developed in response to social distancing measures that ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader in ... “BUILDING FOR LIFE.” The adoption of this taglines comes at a time of ... capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... the leading global provider of advanced delivery technologies, development, and manufacturing solutions for ... they have entered into a strategic partnership whereby Catalent will provide support for ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... for the life sciences industry, today announced the release of its signature ... for Medical Science Liaisons (MSLs) and other field medical professionals. , ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said ... on the market and we were pleased that the IFT jury recognized that.” reFRESH™ ... creating a natural way to extend the shelf life and improve the safety of ...
Breaking Biology Technology:
Cached News: