HOME >> BIOLOGY >> NEWS
News tips from The Journal of Neuroscience

1. Microarray in 5 Regions and 8 Strains
Noah E. Letwin, Neri Kafkafi, Yoav Benjamini, Cheryl Mayo, Bryan C. Frank, Troung Luu, Norman H. Lee, and Greg I. Elmer

This week, Letwin et al. began a search for genes that underlie complex behaviors, eschewing the conventional hunt for individual genes in favor of a behavioral genetics approach. They fabricated microarrays containing >26,000 mouse cDNAs. Gene expression patterns were measured across five brain regions--the prefrontal cortex, ventral striatum, temporal lobe, periaqueductal gray, and cerebellum--and across eight inbred strains of mice that are considered genetically and behaviorally diverse. By the authors' criteria, each region had hundreds (range, 2451251) of regionally enriched genes that were conserved across strains. Roughly similar numbers of genes differed in each region between strains. In parallel, they compared behavioral phenotypes for anxiety, locomotor activity, ethanol-induced locomotor activity, and seizure susceptibility, and tried to link the regional expression differences with behavioral phenotypes. Some of the genes that correlated with behaviors were linked to already established quantitative trait loci, thus validating the potential utility of this daunting task.

2. Small Molecule p75NTR Ligands
Stephen M. Massa, Youmei Xie, Tao Yang, Anthony W. Harrington, Mi Lyang Kim, Sung Ok Yoon, Rosemary Kraemer, Laura A. Moore, Barbara L. Hempstead, and Frank M. Longo

The neurotrophin receptor p75NTR is a bit of a chameleon, leading to apoptosis or cell survival, depending on the activating ligand and on the expression of tropomyosin-related kinase (Trk) neurotrophin receptors. Binding of nerve growth factor (NGF) to p75NTR promotes neuron survival, whereas proNGF induces cell death, as does the unbound monomeric p75NTR. In this issue, Massa et al. report on several small nonpeptide ligands that bind p7
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
16-May-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... 2020 , ... Accumen Inc. is helping healthcare get better, ... Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has been ... 10 years. Early in the COVID-19 crisis, we identified supply chain gaps and ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/18/2020)... SAN ANTONIO (PRWEB) , ... July 16, 2020 ... ... PLOS ONE that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise ... (NICU) environment. The study reported that the Neoasis™ device attenuated the alarm sounds ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/10/2020)... ... 08, 2020 , ... Bode Technology, a leading ... operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical ... provides a turnkey solution that includes a comprehensive collection and virus-management program ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT ... Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: ... hosted an elite awards program, highlighting outstanding examples of how technology innovations and ...
(Date:6/28/2020)... JOSE, Calif. (PRWEB) , ... June 25, 2020 ... ... globe, researchers are racing to develop a vaccine or drug treatment. In an ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic ...
Breaking Biology Technology:
Cached News: