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News tips from The Journal of Neuroscience

ticosteroids and Rat Neural Stem Cells
Maria Sundberg, Suvi Savola, Anni Hienola, Laura Korhonen, and Dan Lindholm

In this week's Journal, Sundberg et al. examined potential links between stress, steroids, and stem cells. The authors reported that neuronal stem cells (NSCs) isolated from embryonic rat brains expressed glucocorticoid receptors (GRs) and mineralocorticoid receptors. The potent synthetic glucocorticoid dexamethasone (Dex) also decreased NSC proliferation in vivo. A 3 d treatment of embryonic day 14 pregnant rats reduced NSCs in the pups by one-third, an effect attributed to decreased proliferation rather than increased cell death. The authors estimated that the treatment half-saturated glucocorticoid receptors, making it plausible that the effects could occur under physiological conditions. In vitro, Dex activation of GRs increased activity of the ubiquitin proteasome system but not the glycogen synthase kinase- signaling pathway, both of which regulate the cell cycle protein cyclin D1. Dex increased the ubiquitination of cyclin D1, thereby targeting it for degradation and blunting its proliferative effects. Overexpression of cyclin D1 increased NSC proliferation and offset the effect of Dex.


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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
16-May-2006


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