HOME >> BIOLOGY >> NEWS
News tips from The Journal of Neuroscience

1. The Cytoskeleton and the Paranode
Yasuhiro Ogawa, Dorothy P. Schafer, Ido Horresh, Vered Bar, Kimberly Hales, Yang Yang, Keiichiro Susuki, Elior Peles, Michael C. Stankewich, and Matthew N. Rasband

Paranodal junctions that flank nodes of Ranvier contain a cytoskeleton specialized to prevent membrane protein diffusion in and out of the nodes. This week Ogawa et al. used three known paranodal cell adhesion molecules to fish out additional paranodal molecules. As starting material, the authors isolated optic nerve membranes enriched in glial protein NF155 and the axonal proteins Caspr and contactin. Of 51 molecules identified by liquid chromatographytandem mass spectrometry, II spectrin, II spectrin, and ankyrinB cofractionated with Caspr as part of a paranodal complex. These proteins also associated with protein 4.1B. Immunostaining revealed these cytoskeletal proteins at paranodes in the central and peripheral nervous system. An enzymatic treatment that caused myelin retraction from the axon left II spectrin and ankyrinB staining intact, identifying them as axonal proteins. AnkyrinB localization required Caspr, but not the juxtaparanodal protein Caspr2, indicating that paranodal axonglia interactions are required for formation of the paranodal cytoskeleton.

2. Lining Up the Hair Cells
Mireille Montcouquiol, Nathalie Sans, David Huss, Jacob Kach, J. David Dickman, Andrew Forge, Rivka A. Rachel, Neal G. Copeland, Nancy A. Jenkins, Debora Bogani, Jennifer Murdoch, Mark E. Warchol, Robert J. Wenthold, and Matthew W. Kelley

How is it that cells in an epithelial sheet line up with the same orientation? In this week's Journal, Montcouquiol et al. examine some of the proteins involved in this planar cell polarity (PCP) problem in the mammalian system that perhaps best illustrates the process: cochlear hair cells. Mutations in mice have led to the identification of Vangl2, Scrb1, and Celsr1 as genes integral to PCP.
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
9-May-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... Canada and BADEN-BADEN, Germany , ... a leading global financial services provider, today announced an agreement ... passive behavioural biometrics, to join forces. The partnership will enable ... mitigation strategies in compliance with local data protection regulation. ... In order ...
(Date:12/15/2016)... Dec. 15, 2016 Advancements in ... health wellness and wellbeing (HWW), and security ... three new passenger vehicles begin to feature ... recognition, heart beat monitoring, brain wave monitoring, ... monitoring, and pulse detection. These will be ...
(Date:12/12/2016)... -- Researchers at Trinity College, Dublin, are opening up ... material with Silly Putty. The mixture (known as "G-putty") ... sense pulse, blood pressure, respiration, and even the ... The research team,s findings were published Thursday in ... Due ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... and GAITHERSBURG, Md. , ... PIP) and Altimmune, Inc., a privately-held immunotherapeutics company ... a definitive agreement for the merger of PharmAthene ... investors include Novartis Venture Fund, HealthCap, Truffle Capital ... a fully-integrated and diversified immunotherapeutics company with four ...
(Date:1/19/2017)... 2017 AquaBounty Technologies, Inc. (AIM: ABTU; NASDAQ: ... aquaculture and a majority-owned subsidiary of Intrexon Corporation (NYSE: ... the listing of its common shares on the NASDAQ ... "AquaBounty,s listing on NASDAQ represents an important ... to the U.S. markets as we advance plans for ...
(Date:1/19/2017)... ... January 18, 2017 , ... LabRoots , the leading ... the world, was today awarded the "Best Science & Technology Social Networking Service ... and decided upon by a dedicated team of researchers and analysts. , The ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... the full spectrum of drug and device development, and Prism Clinical Research ... and clinicians, today announced Verified Clinical Trials (VCT) has been selected ...
Breaking Biology Technology:
Cached News: