HOME >> BIOLOGY >> NEWS
News tips from The Journal of Neuroscience

1. The Cytoskeleton and the Paranode
Yasuhiro Ogawa, Dorothy P. Schafer, Ido Horresh, Vered Bar, Kimberly Hales, Yang Yang, Keiichiro Susuki, Elior Peles, Michael C. Stankewich, and Matthew N. Rasband

Paranodal junctions that flank nodes of Ranvier contain a cytoskeleton specialized to prevent membrane protein diffusion in and out of the nodes. This week Ogawa et al. used three known paranodal cell adhesion molecules to fish out additional paranodal molecules. As starting material, the authors isolated optic nerve membranes enriched in glial protein NF155 and the axonal proteins Caspr and contactin. Of 51 molecules identified by liquid chromatographytandem mass spectrometry, II spectrin, II spectrin, and ankyrinB cofractionated with Caspr as part of a paranodal complex. These proteins also associated with protein 4.1B. Immunostaining revealed these cytoskeletal proteins at paranodes in the central and peripheral nervous system. An enzymatic treatment that caused myelin retraction from the axon left II spectrin and ankyrinB staining intact, identifying them as axonal proteins. AnkyrinB localization required Caspr, but not the juxtaparanodal protein Caspr2, indicating that paranodal axonglia interactions are required for formation of the paranodal cytoskeleton.

2. Lining Up the Hair Cells
Mireille Montcouquiol, Nathalie Sans, David Huss, Jacob Kach, J. David Dickman, Andrew Forge, Rivka A. Rachel, Neal G. Copeland, Nancy A. Jenkins, Debora Bogani, Jennifer Murdoch, Mark E. Warchol, Robert J. Wenthold, and Matthew W. Kelley

How is it that cells in an epithelial sheet line up with the same orientation? In this week's Journal, Montcouquiol et al. examine some of the proteins involved in this planar cell polarity (PCP) problem in the mammalian system that perhaps best illustrates the process: cochlear hair cells. Mutations in mice have led to the identification of Vangl2, Scrb1, and Celsr1 as genes integral to PCP.
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
9-May-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: News tips from The Journal Neuroscience

(Date:10/22/2014)... identity analyst firm Acuity Market Intelligence forecasts that in ... have a chip-based National eID card, including near-complete regional ... Asia , with its vast population, is expected ... of all National eID cards issued between 2014 and ... National eID Industry Report: 2014 Edition" — projects ...
(Date:10/18/2014)... a group of 2,000 patients referred for evaluation ... potential molecular diagnosis for 25 percent, including detection ... new mutations contributing to disease, according to a ... is being released to coincide with the American ... sequencing analyzes the exons or coding regions of ...
(Date:10/17/2014)... for the first time how bacteria can grow directly ... the opportunity to get tremendous insights into bacteria behavior ... discovered the bacterial growth in chronic lung infections among ... by the immune cells. The researchers discovered the immune ... bacteria, forcing the bacteria to switch to a much ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
(Date:10/22/2014)... Oct. 22, 2014 Research and ... "Global DNA Diagnostics Market (Product types, Application, ... Global Trends, Company Profiles, Demand, Insights, Analysis, Research, ... report to their offering. ... applications, techniques, end users and Geography) Global Size, ...
(Date:10/22/2014)... October 22, 2014 Involution Studios ... release of a new infographic, Understanding Ebola . ... a beautifully designed, easy to follow informative tool for ... of outbreak, symptoms and prevention. , "As the news ... the 2014 Ebola outbreak represents not only a healthcare ...
(Date:10/22/2014)... According to new market research ... (Consulting, Integration, Deployment & Support), by Service Model ... Private, Others (Hybrid & Community)) - Global Forecast ... the Cloud Professional Services Market into various sub-segments ... It also identifies the drivers and restraints for ...
(Date:10/22/2014)... KONG , Oct. 22, 2014  aTyr Pharma ... that rare disease expert John C. McKew , ... McKew brings more than two decades of expertise in ... Institutes of Health, Wyeth Research and Genetics Institute, Inc. ... aTyr,s efforts to expand and translate its novel Physiocrine ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
Cached News: