HOME >> BIOLOGY >> NEWS
News tips from The Journal of Neuroscience

1. The Cytoskeleton and the Paranode
Yasuhiro Ogawa, Dorothy P. Schafer, Ido Horresh, Vered Bar, Kimberly Hales, Yang Yang, Keiichiro Susuki, Elior Peles, Michael C. Stankewich, and Matthew N. Rasband

Paranodal junctions that flank nodes of Ranvier contain a cytoskeleton specialized to prevent membrane protein diffusion in and out of the nodes. This week Ogawa et al. used three known paranodal cell adhesion molecules to fish out additional paranodal molecules. As starting material, the authors isolated optic nerve membranes enriched in glial protein NF155 and the axonal proteins Caspr and contactin. Of 51 molecules identified by liquid chromatographytandem mass spectrometry, II spectrin, II spectrin, and ankyrinB cofractionated with Caspr as part of a paranodal complex. These proteins also associated with protein 4.1B. Immunostaining revealed these cytoskeletal proteins at paranodes in the central and peripheral nervous system. An enzymatic treatment that caused myelin retraction from the axon left II spectrin and ankyrinB staining intact, identifying them as axonal proteins. AnkyrinB localization required Caspr, but not the juxtaparanodal protein Caspr2, indicating that paranodal axonglia interactions are required for formation of the paranodal cytoskeleton.

2. Lining Up the Hair Cells
Mireille Montcouquiol, Nathalie Sans, David Huss, Jacob Kach, J. David Dickman, Andrew Forge, Rivka A. Rachel, Neal G. Copeland, Nancy A. Jenkins, Debora Bogani, Jennifer Murdoch, Mark E. Warchol, Robert J. Wenthold, and Matthew W. Kelley

How is it that cells in an epithelial sheet line up with the same orientation? In this week's Journal, Montcouquiol et al. examine some of the proteins involved in this planar cell polarity (PCP) problem in the mammalian system that perhaps best illustrates the process: cochlear hair cells. Mutations in mice have led to the identification of Vangl2, Scrb1, and Celsr1 as genes integral to PCP.
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
9-May-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: News tips from The Journal Neuroscience

(Date:2/24/2015)... -- This report analyzes the worldwide markets for Face and Voice ... Voice Biometrics. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Latin America . Annual estimates and forecasts are ... analysis is provided for these markets. Market data and analytics are ...
(Date:2/13/2015)... 13, 2015 ACT Genomics Co., Ltd., ... to transform cancer genomic information into precision diagnosis ... has raised US$ 8 million in the its first ... Taipei, Taiwan , ACT Genomics has ... the aim to implement next generation sequencing (NGS) ...
(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America recently ... for carbon nanotube (CNT) macrostructures, including sheets, yarns and ... (UTD). Leveraging the vast industrial resources of ... Japan , Lintec of America is forming the ... TX , focusing on scaling up the manufacturing ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16ACT Genomics Raises $8 Million in its First Private Funding Round 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4
(Date:3/4/2015)... , Mar. 04, 2015 Research and Markets ... addition of Jain PharmaBiotech,s new report "Biomarkers ... offering. This report follows the ... that can be objectively measured and evaluated as ... as well as pharmacological responses to a therapeutic ...
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 ... leader in Personalized Medicine, is excited to announce ... Genetic Testing to Optimize the Management of Pain”. ... available at Medscape.com for the next year. The ... professionals how to recognize inadequate pain treatments, integrate ...
(Date:3/4/2015)... 04, 2015 Follow us on ... of the fastest growing technologies in the life sciences ... visualization is driving growth in nucleic acid detection technologies ... of gene expressions will continue to benefit the qPCR ... fields ranging from pharma, biotech, food & beverage to ...
(Date:3/3/2015)... SAN DIEGO and TORONTO, March 3, 2015 /PRNewswire/ - ... company developing new therapeutics and molecular diagnostics that target ... for the quarter and seventh-month period ended December 31, ... changed its fiscal year end from May 31 to ... periods we are reporting today are for the quarter ...
Breaking Biology Technology:Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 2Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 3Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 4Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 5Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 6Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 7Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 8Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 9Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 10Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 11Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 12
Cached News: