HOME >> BIOLOGY >> NEWS
News tips from The Journal of Neuroscience

1. The Glutamate Receptor δ2 Subunit in Cerebellar LTD
Satoshi Yawata, Hiroshi Tsuchida, Mineko Kengaku, and Tomoo Hirano

The glutamate receptor subunit δ2 has been an enigma. It does not fit with the functional grouping of glutamate receptors, but it is selectively expressed in cerebellar Purkinje cells (PNs) and is required for induction of long-term depression (LTD) at parallel fiber-Purkinje cell synapses. This week, Yawata et al. identified a proximal cytoplasmic domain in δ2 that is necessary for LTD and for interaction with PICK1 (protein interacting with C kinase 1). The authors transfected GluRδ2-deficient PNs with various deletion mutants. The PDZ (postsynaptic density 95/Discs large/zona occludens-1)-binding region was not required for localization to dendritic spines or for LTD. A mutant truncated after the first 21 amino acids of the C terminus rescued LTD, whereas one containing only 13 amino acids of the C terminus did not. Expression of a peptide containing amino acids C1420 acted as a dominant negative, blocking LTD perhaps by interfering with a δ2PICK1 interaction.

2. Growing Axons Find NG2 Cells Attractive
Zhongshu Yang, Ryusuke Suzuki, Stephen B. Daniels, Christopher B. Brunquell, Christopher J. Sala, and Akiko Nishiyama

This week, Yang et al. examined the effect on neurite outgrowth of glial cells that express the chondroitin sulfate proteoglycan NG2. The authors refer to these cells as NG2 cells, but as they differentiate into oligodendrocytes, they are more commonly called oligodendrocyte precursor cells. NG2 can inhibit neurite outgrowth, but the authors found that neurites of hippocampal neurons in short-term cultures preferred to make contact with NG2 cells rather than with a polylysine-coated surface or mature oligodendrocytes. In vivo, axonal growth cones made extensive contact with NG2 cells in the corpus callosum. Neurons extended processes on astrocy
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
4-Apr-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2018)... ... November 27, 2018 , ... Victrex has ... solution with a broader range of usage temperature compared to existing polymers such ... its new VICTREX CT™ 200 for dynamic sealing applications where gases such as ...
(Date:11/27/2018)... ... 2018 , ... Veni Vici, or Anthony, is a competitive Hunter-Jumper owned by Lisa Companioni Smith. ... time, he was fourteen years old and Lisa was told he would never jump again ... trail horse. Devasted, Lisa sought the expert opinion of veterinarian and surgeon, Dr. Ruth-Anne ...
(Date:11/20/2018)... ... ... Cloudponics , maker of the GroBox , the intelligent, fully-automated ... for its industry-leading product during the holiday season. , Customers can save up ... payment options available on the Cloudponics website . , “We aim, through ...
Breaking Biology News(10 mins):
(Date:11/11/2018)... ... 2018 , ... Triple W, an innovator of connected health devices, today announced ... DFree ®, the first health tech wearable device for incontinence that monitors how ... bathroom. The announcement was made during CES Unveiled New York, an invite-only tech event ...
(Date:11/7/2018)... ... November 07, 2018 , ... Since September of this ... awareness of the adult tissue stem cell counting problem in stem cell medicine ... is intensifying this effort with new educational publications and presentations at clinical trial ...
(Date:11/5/2018)... Tenn. (PRWEB) , ... November 05, 2018 , ... ... radiology and telemedicine company backed by Siemens Healthineers and several healthcare VC firms ... based radiology solution and making a history by purchasing tokens and obtaining its ...
(Date:11/3/2018)... ... 01, 2018 , ... Triangle Insights Group, a premier life sciences consulting firm, ... private companies in the United States, appearing on this year’s Inc. 5000 list. ... percentage revenue growth over the previous three years. , Separately, Triangle Insights was ...
Breaking Biology Technology:
Cached News: