News tips from the Journal of Neuroscience

1. The Battle of the LTDs in the Cerebellum
Wolfgang Mittmann and Michael Husser

Purkinje cells provide the sole output of cerebellar cortex, thus serving as the final common pathway for cerebellar synaptic integration and plasticity. The cellular plasticity associated with cerebellar motor learning is thought to arise from long-term depression (LTD) of excitatory parallel fibers (PFs) triggered by simultaneous climbing fiber (CF) activity. Mittmann and Husser show this week that its not quite so simple: plasticity at feedforward inhibitory synapses is also important. The authors recorded from spontaneously spiking Purkinje cells in rat cerebellar slices. PF EPSPs increased Purkinje cell firing, whereas interneuron inhibitory PSPs reduced spiking. When CF inputs were paired with PF EPSPs or with interneuron IPSPs, LTD occurred in both inputs, but with opposite effects on Purkinje cell spiking. The net effect of this battle of the LTDs varied with inhibitory/excitatory input ratios. Plasticity produced a reduction in Purkinje cell spike output when there was only a small inhibitory component.

2. Dynein, LIS1, and Growth Cones
Peter W. Grabham, Garrett E. Seale, Malika Bennecib, Daniel J. Goldberg, and Richard B. Vallee

The molecular motor dynein and its regulatory factors dynactin and LIS1 associate with microtubules to promote cellular migration and axonal growth. This week, Grabham et al. examined the role of these molecules in growth cone dynamics. The authors treated embryonic chick dorsal root ganglion (DRG) neurons with laminin, which caused rapid reorganization of microtubules in growth cones as well as dynein staining that was concentrated at the leading edge. Dynactin and LIS1 were colocalized with dynein. A similar staining pattern was observed in growth cones of rat hippocampal neurons. Knockdown of LIS1 by RNA interference delayed polarization of hippocampal neurons and decreased axonal lengths. Dynein

Contact: Sara Harris
Society for Neuroscience

Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:

(Date:7/10/2020)... ... July 08, 2020 , ... ... Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 ... but what is the most effective way to complete one? Will the study ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. ... of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), ... Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 16, 2020 , ... After ... begins. The completion of a great surgery is only the beginning of a successful ... the research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
Breaking Biology Technology:
Cached News: