HOME >> BIOLOGY >> NEWS
News tips from the Journal of Neuroscience

1. Tracking Down Anomalous L Channels
Alexandra Koschak, Gerald J. Obermair, Francesca Pivotto, Martina J. Sinnegger-Brauns, Jrg Striessnig, and Daniela Pietrobon

In this week's Journal, Koschak et al. identify Cav1.2 as the pore-forming subunit of anomalous L-type calcium channels in neurons, a subclass of L-type channels that show long reopenings at negative voltages after a strong depolarization. These channels coexist with conventional L-type channels in rat cerebellar granule cells as well as other neurons. The authors found by quantitative reverse transcription-PCR that the bulk of L-type calcium channel transcripts in granule cells encoded Cav1.2 subunits, whereas the remainder encoded Cav1.3. Single-channel recording from granule cells in Cav1.3-/- mice revealed normal amounts of both gating types. In Cav1.2DHP-/- mice, which express mutant Cav1.2 channels that are insensitive to dihydropyridines (DHPs), the long reopenings in neurons treated with DHP were similar to anomalous currents in wild-type neurons and shorter than typical DHP-induced long openings. The authors suggest that the anomalous openings may drive L-type channel-dependent gene transcription in long-lasting plasticity.


2. An Interhemispheric Effect on Whisker Plasticity
Stanislaw Glazewski, Brett L. Benedetti, and Alison L. Barth

Glazewski et al. did some fancy whisker trimming in mice to examine experience-dependent plasticity in barrel cortex. In rodents, whisker deflection excites neurons in the contralateral somatosensory cortex, whereas concurrent stimulation of ipsilateral whiskers is inhibitory. The authors recorded responses in single neurons in barrel cortex after deflection of contralateral whiskers. Mice deprived of ipsilateral whiskers for 1 week had increased cortical receptive fields to contralateral whisker stimulation. Next, the mi
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
3-Apr-2007


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: