News tips from the Journal of Neuroscience

1. TRPV1 Antagonists to Warm the Soul
Narender R. Gavva, Anthony W. Bannon, Sekhar Surapaneni, David N. Hovland Jr, Sonya Lehto, Anu Gore, Todd Juan, Hong Deng, Bora Han, Lana Klionsky, Rongzhen Kuang, April Le, Rami Tamir, Jue Wang, Brad Youngblood, Dawn Zhu, Mark H. Norman, Ella Magal, James J. S. Treanor, and Jean-Claude Louis

For pain-sensing neurons, the vanilloid receptor TRPV1 is a jack-of-all-trades being activated by heat, acid, and capsaicin. This week, Gavva et al. show that TRPV1 is also tonically active as manifested by an increase in body temperature after antagonist administration. The authors treated rats with the TRPV1 antagonist (E)-3-(4- t-butylphenyl)-N-(2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)acrylamide (AMG9810), which blocked hypothermia induced by capsaicin. However, AMG9810 also increased body temperature by 1C within 30 minutes. A variety of TRPV1 antagonists had the same effect, indicating that a sub-modality-specific block was not responsible. The hyperthermia was mediated in the periphery, occurred in multiple species including primates, and correlated with block of either capsaicin or heat activation of the channel. Because TRPV1 agonists like capsaicin cause hypothermia, these results suggest that tonic activity of TRPV1 is involved in body temperature regulation. TRPV1 antagonists may warm the soul of subjects, but perhaps not those trying to design compounds to treat chronic pain.

2. Rho, Endocytosis, and Oligodendroglial Membrane Growth
Angelika Kippert, Katarina Trajkovic, Lawrence Rajendran, Jonas Ries, and Mikael Simons

When forming myelin, oligodendrocytes have a big job in creating all that membrane. Specialized proteolipid protein (PLP) components of myelin membranes are expressed in the absence of neurons, but an unknown diffusible neuronal factor triggers a switch in PLP trafficking. This week, Kippert et al. investigated the trafficking of PLP from late endosomes/lys

Contact: Sara Harris
Society for Neuroscience

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