HOME >> BIOLOGY >> NEWS
News tips from the Journal of Neuroscience

Mixing and Matching NMDA Subunits
Rana A. Al-Hallaq, Thomas P. Conrads, Timothy D. Veenstra, and Robert J. Wenthold

Much has been written about the subunit composition of hippocampal NMDA receptors and their differential contributions to functions ranging from learning to neurodegeneration. Although NMDA receptors can be di-heteromeric, two NR1 subunits and two identical NR2 subunits, they can also be tri-heteromeric, containing NR1, NR2A, and NR2B subunits. Al- Hallaq et al. set out to examine receptors according to subunit content. The authors performed serial immunoprecipitations on membrane fractions from rat hippocampus. After depleting NR2A or NR2B, they quantified the remaining NR2-containing receptors. About two-thirds of total NR2A and NR2B subunits resided in di-heteromeric receptors, and one-third in tri-heteromeric receptors. Membrane-associated guanylate kinases bound equally to receptors containing NR2A or NR2B, but several synapse-associated proteins associated preferentially with NR2A, whereas collapsin response mediator protein 2 favored NR2B. End of story" Probably not, because only a fraction of NMDA receptors in mature animals could be extracted; thus synaptic receptors may have been underrepresented.


Intrinsic Membrane Properties and Homeostatic Regulation
Kara G. Pratt and Carlos D. Aizenman

Remaining flexible (plastic) in response to ongoing neuronal activity is not limited to synapses, as Pratt and Aizenman demonstrate this week. The authors examined the intrinsic membrane excitability of tadpole optic tectal neurons during the period from early synapse formation (stage 42/43) to stage 49, when tectal field receptive fields become more refined. Measured sodium current amplitudes increased slightly between stage 42/43 and 4446 and then declined by stage 49. The depolarization required to reach spike threshold was also lower at stage 4446 than at stage 49. This
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
30-Jul-2007


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. Tips from the Journals of the American Society for Microbiology
5. Journalists can register now for ECCO 14 -- the European Cancer Conference
6. Journal of Alzheimers Disease achieves significant impact factor
7. News tips from the Journal of Neuroscience
8. Highlights from the July 2007 Journal of the American Dietetic Association
9. News tips from the Journal of Neuroscience
10. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years
11. News tips from the Journal of Neuroscience

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... , ... AMRI, a global contract research, development and manufacturing ... and quality of life, will now be offering its impurity solutions as a ... requirements for all new drug products, including the finalization of ICH M7 earlier ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study ... in frozen and fresh in vitro fertilization (IVF) transfer cycles. The ... IVF success. , After comparing the results from the fresh and frozen transfer ...
(Date:10/10/2017)... ... 2017 , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on ... DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of ...
Breaking Biology Technology:
Cached News: