HOME >> BIOLOGY >> NEWS
News tips from the Journal of Neuroscience

  1. Activating Transcription Factor 3 and Regeneration
    Rhona Seijffers, Charles D. Mills, and Clifford J. Woolf

    Injury of peripheral axons results in a regenerative response from the central as well as the peripheral process of a dorsal root ganglion (DRG) neuron. This conditioning effect is mediated by altered transcription of multiple genes and involves both enhanced axonal growth and reduced inhibition by myelin. Seijffers et al. concentrated on the transcription factor ATF3 as a candidate mediator of the enhanced growth because ATF3 is expressed after peripheral, but not central, axonal injury. The authors generated transgenic mice that expressed ATF3 constitutively in DRG neurons. After sciatic nerve crush, ATF3 transgenic mice displayed early nerve regeneration similar to wild-type (WT) mice after a preconditioning lesion. Preconditioned WT mice extended axons into the spinal cord after a dorsal column injury, but axons in ATF3 transgenic mice did not. Similarly, ATF3-expressing neurons were unable to overcome myelin inhibition. Thus ATF by itself did not completely recapitulate the benefits of preconditioning.

  2. Making Synapse with New Spines Takes Time
    U. Valentin Ngerl, German Kstinger, John C. Anderson, Kevan A. C. Martin, and Tobias Bonhoeffer

    Sometimes if you want something well made, you have got to allow some time. So it goes it seems with making synapses. Ngerl et al. this week focused on the temporal requirements for the synapse formation at newly formed spines. The authors used two-photon laser-scanning microscopy to image hippocampal slice cultures. After theta-burst stimulation (TBS), CA1 pyramidal neurons generated new dendritic spines that lasted throughout a 19 h imaging period. Spines were visualized in living slices with calcein dye. Most preexisting spines had mature synapses with synaptic clefts and adjacent vesicle-filled boutons. The authors then fixed slices at differ
    '"/>



Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
24-Jul-2007


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. Tips from the Journals of the American Society for Microbiology
5. Journalists can register now for ECCO 14 -- the European Cancer Conference
6. Journal of Alzheimers Disease achieves significant impact factor
7. News tips from the Journal of Neuroscience
8. Highlights from the July 2007 Journal of the American Dietetic Association
9. News tips from the Journal of Neuroscience
10. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years
11. News tips from the Journal of Neuroscience

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/28/2020)... PRUSSIA, Pa. and CAMBRIDGE, Mass. (PRWEB) , ... ... ... to solving complex problems for life sciences companies and government agencies, announced that ... life sciences hubs in the country. Tunnell’s Cambridge office will be in the ...
(Date:1/27/2020)... , ... January 27, 2020 , ... On Thursday, February ... Solutions Life Sciences, Reed Tech and Richard Castle, Global Account Manager Medical ... discussing the procedure, other topics include EU MDR timing deadlines, best practices in creating ...
(Date:1/24/2020)... ... January 24, 2020 , ... Shoreline Biome , a microbiome research ... announced that the company will debut a novel new DNA isolation kit at the ... product, Shoreline Biome's Rapid Prep kit, is a fast and easy-to-use kit designed for ...
Breaking Biology News(10 mins):
(Date:1/10/2020)... ... January 09, 2020 , ... ... Development establishes benchmarks for the vendor qualification process, a critical element of ... process volume and complexity of the vendor qualification process creates delays in initiation ...
(Date:1/8/2020)... ... January 08, 2020 , ... RMA ... couples and individuals grow their family, has announced that five of their Board-Certified ... Connolly. Since 1991, the renowned publishing company Castle Connolly has compiled ...
(Date:1/7/2020)... (PRWEB) , ... January 06, 2020 , ... ... Control, today announced its expansion into whole-home smart lighting with two new products: ... Switch unlocks the ability for homeowners and homebuilders to affordably add high-end smart ...
(Date:12/30/2019)... ... December 30, 2019 , ... Leak Detection ... for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries is pleased to ... compliant software program specific to the custom-built helium leak testing systems it designs ...
Breaking Biology Technology:
Cached News: